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Patient cohorts with corresponding diagnosis as identified by an expert neuropathologist on postsurgical specimens
Site No., Initial Diagnosis Category Percentage CRN/Tumor as Identified by Expert No. of Cases
Site 1 
    Primary tumors Predominant tumor <20% CRN, >80% tumor 12
Predominant CRN >80% CRN, <20% tumor 10
    Metastatic tumors Predominant tumor <20% CRN, >80% tumor 12
Predominant CRN >80% CRN, <20% tumor 8
Site 2 
    Primary tumors Predominant tumor <20% CRN, >80% tumor 4
Predominant CRN >80% CRN, <20% tumor 1
Mixed 30% CRN, >70% tumor 2
    Metastatic tumors Predominant tumor <20% CRN, >80% tumor 1
Predominant CRN >80% CRN, <20% tumor 1
Mixed 50% CRN, 50% tumor 1 (50%)
Site 3 
    NPC Pure 100% CRN 13
TCIA 
    Glioblastoma Pure 100% Tumor 10
Note:—NPC indicates nasopharyngeal carcinoma.

Site No., Initial Diagnosis	Category	Percentage CRN/Tumor as Identified by Expert	No. of Cases
Site 1
Primary tumors	Predominant tumor	<20% CRN, >80% tumor	12
Primary tumors	Predominant CRN	>80% CRN, <20% tumor	10
Metastatic tumors	Predominant tumor	<20% CRN, >80% tumor	12
Metastatic tumors	Predominant CRN	>80% CRN, <20% tumor	8
Site 2
Primary tumors	Predominant tumor	<20% CRN, >80% tumor	4
	Predominant CRN	>80% CRN, <20% tumor	1
	Mixed	30% CRN, >70% tumor	2
Metastatic tumors	Predominant tumor	<20% CRN, >80% tumor	1
	Predominant CRN	>80% CRN, <20% tumor	1
	Mixed	50% CRN, 50% tumor	1 (50%)
Site 3
NPC	Pure	100% CRN	13
TCIA
Glioblastoma	Pure	100% Tumor	10