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Table 3: [¹⁸F] FDG-PET/CT characteristics and selected texture parameters differentiating lymph node characterization in patients with head and neck squamous cell carcinoma without HIV infection (group 3 vs 4)
Texture Parameter Benign Nodes (n = 39) Malignant Nodes (n = 22) P Value^{^a} Cutoff AUC^{^b} (GLIMMROC)
Mean SD Mean SD
Node characteristics 
    Size (cm) 1.439 0.048 1.687 0.831 .079 DNC 0.643
    Volume (cm³) 1.122 0.147 3.468 4.718 .001^{^c} >2.599 0.702
    SUVmax 3.228 0.315 6.438 4.811 .007^{^c} >3.980 0.731
Histogram 
    Mean 670.6 68.4 751.8 137.3 .022^{^c} >738.1 0.705
    Geometric mean 225.9 50.6 297.6 124.5 .020^{^c} >257.5 0.667
    Harmonic mean 24.12 4.21 29.57 9.42 .020^{^c} >25.5 0.678
IQR 1064.3 63.9 865.0 360.2 .022^{^c} <1017.0 0.723
Fourth moment 8.71E+10 5.74E+09 9.41E+10 1.00E+10 .018^{^c} >9.38E+10 0.698
GLCM 
    Contrast 102.5 18.2 81.8 28.3 .015^{^c} <75.7 0.754
    Energy 0.041 0.022 0.072 0.055 .034^{^c} >0.058 0.712
    Homogeneity 0.475 0.056 0.541 0.104 .029^{^c} >0.528 0.735
GLRL 
    SRE 0.164 0.011 0.154 0.019 .036^{^c} <0.153 0.695
    RLN 0.183 0.014 0.170 0.023 .034^{^c} <0.172 0.698
    RHGE 254.2 77.2 367.0 193.6 .016^{^c} >305.4 0.739
    LRLGE 322.6 91.4 469.8 231.9 .006^{^c} >397.1 0.759
    LRHGE 246.2 60.5 352.7 168.8 .003^{^c} >340.9 0.760^{^d}
Laws features 
    L1 1,130,272.9 280,670.9 876,676.6 413,942.2 .024^{^c} <911,080.5 0.722
Note:—DNC indicates did not converge; IQR, interquartile range; GLIMMROC, generalized linear mixed model receiver operating characteristic.
↵a Indicates a significant difference by the mixed linear regression model (Proc MIXED) to adjust the variance-covariance matrix among multiple values recorded for each patient (P < .05).
↵b Using the generalized linear mixed model (GLIMMROC).
↵c Significant.
↵d The highest AUC among 41 texture features.