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Table 2: Brain MRI findings of patients with pediatric-onset NMOSD vs ADEM
Characteristics NMOSD (n = 10) ADEM (n = 10) P Value
Lesion localization/infratentorial 
    Medulla 4 (40%) 2 (20%) 1
        Area postrema 2 (20%) 1 (10%) 1
    Cerebellum 2 (20%) 2 (20%) 1
    Pons 4 (40%) 7 (70%) .37
    Middle cerebellar peduncle 4 (40%) 6 (60%) .65
    Periventricular 5 (50%) 6 (60%) 1
    Mesencephalon 2 (20%) 4 (40%) .63
        Periaqueductal 1 (10%) 1 (10%) 1
Lesion localization/supratentorial 
    Diencephalon 
        Thalamus 1 (10%) 7 (70%) .02^{^a}
        Hypothalamus 0 3 (30%) .21
        Periventricular 0 5 (50%) .37
    Internal capsule 0 5 (50%) .03^{^a}
    Basal ganglia 1 (10%) 3 (30%) .58
    Corpus callosum 1 (10%) 2 (20%) 1
    Cerebral white matter 
        Periventricular 3 (30%) 6 (60%) .37
        Juxtacortical-subcortical 5 (50%) 9 (90%) .57
    Cerebral cortex 0 3 (30%) .21
Size (≥2 cm) 6 (60%) 8 (80%) .63
T1 hypointensity 7 (70%) 6 (60%) 1
Expansion 7 (70%) 8 (80%) 1
Contrast enhancement 8 (80%) 5 (50%) .35
Enhancement pattern 
    Patchy, nodular 5 2 
    Diffuse 0 3 
    Leptomeningeal 3 0 
    Ring-incomplete ring 1 1 
    Perivenular 1 0 
Restricted diffusion 2^{^b} 3 (30%) 1
↵a Significant.
↵b DWI was not performed in 2 children with NMOSD.