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Table 3: Diagnostic performance of 6 blinded readers in detection of MTS-related hippocampal signal alteration before and after image processing with a proprietary algorithm
Reader Sensitivity Specificity PPV NPV Accuracy Before processing R1 72.55 98.04 97.37 78.13 0.85 R2 60.78 98.04 96.88 71.43 0.79 R3 43.14 100.00 100.00 63.75 0.72 R4 58.82 92.16 88.24 69.12 0.75 R5 86.27 80.39 81.48 85.42 0.83 R6 66.67 100.00 100.00 75.00 0.83 Mean (SD) 64.71 (14.46) 94.77 (7.61) 93.99 (7.50) 73.81 (7.53) 0.80 (0.05) After Processing R1 74.51 96.08 95.00 79.03 0.85 R2 78.43 98.04 97.56 81.97 0.88 R3 72.55 98.04 97.37 78.13 0.85 R4 78.43 92.16 90.91 81.03 0.85 R5 72.55 98.04 97.37 78.13 0.85 R6 74.51 98.04 97.44 79.37 0.86 Mean (SD) 75.16 (2.68) 96.73 (2.37) 95.94 (2.65) 79.61 (1.57) 0.86 (0.01)
Note:—R1 and R2 indicate radiology residents; R3 and R4, neuroradiology fellows; R5 and R6, attending neuroradiologists; PPV, positive predictive value; NPV, negative predictive value.