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Table 2: Effect of image processing on sensitivity and specificity for detection of optic neuritis on FLAIR and contrast-enhanced T1WI by 6 masked readers including 2 radiology residents (readers 1, 2), 2 neuroradiology fellows (readers 3, 4), and 2 attending neuroradiologists (readers 5, 6)
Reader 1 2 3 4 5 6 Average
Sensitivity for baseline FLAIR image 18/28 16/28 19/28 27/28 19/28 21/28 71.4 ± 13.6
64% 57% 68% 96% 68% 75% 
Sensitivity for processed FLAIR image 26/28 26/28 26/28 27/28 27/28 27/28 94.6 ± 2.0
93% 93% 93% 96% 96% 96% 
Specificity for baseline FLAIR image 28/28 28/28 26/28 20/28 26/28 27/28 92.3 ± 10.7
100% 100% 93% 71% 93% 96% 
Specificity for processed FLAIR image 26/28 25/28 26/28 24/28 26/28 27/28 91.7 ± 3.7
93% 89% 93% 86% 93% 96% 
P value^a <.001 <.001 .02 .02 .01 .01 
Sensitivity for baseline contrast-enhanced image 17/28 18/28 20/28 25/28 19/28 22/28 72.0 ± 10.5
61% 64% 71% 89% 68% 79% 
Sensitivity for processed contrast-enhanced image 22/28 20/28 21/28 23/28 24/28 22/28 78.6 ± 5.1
79% 71% 75% 82% 86% 79% 
Specificity for baseline contrast-enhanced image 18/18 18/18 18/18 13/18 17/18 18/18 94.4 ± 11.1
100% 100% 100% 72% 94% 100% 
Specificity for processed contrast-enhanced image 18/18 18/18 18/18 17/18 17/18 18/18 98.1 ± 2.9
100% 100% 100% 94% 94% 100% 
P value^a <.001 <.001 .002 .12 .01 .003 
↵a P value for improvement of diagnostic performance in the optic neuritis eyes compared with the control eyes.