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Table 1: 
Demographic and clinical data in the study population
ParametersGroup A (≤5 CE-MRI)Group B (≥6 CE-MRI)
Subg. A1 (Gd-DTPA+Gd-BOPTA)Subg. A2 (Gd-BOPTA)Subg. B1 (Gd-DTPA+Gd-BOPTA)Subg. B2 (Gd-BOPTA)
No. of patients5050
20303218
Age (mean) (yr)42.8 ± 11.3540.3 ± 12.12
41.6 ± 9.3443.7 ± 12.640.5 ± 12.239.9 ± 12.3
Sex (M/F)17/3316/34
8/129/219/237/11
EDSS first MRI (mean/median)1.8/11.6/1
2.2/0.51.6/11.5/11.6/1
EDSS last MRI (mean/median)1.9/12.2/1.5
2.3/1.51.6/11.9/1.52.7/2.3
DMT4342
15282616
Mean interval between GBCA administrations (mo)11.8 ± 6.289.2 ± 2.22
12.6 ± 7.6411.2 ± 5.259.0 ± 2.179.6 ± 2.33
No. injections of L-GBCA (mean) (median) (range)3.6 ± 1.43, 4, 1–58.2 ± 2.25, 7, 6–15
3.4 ± 1.50, 4, 1–53.7 ± 1.39, 4, 1–58.9 ± 2.41, 9, 6–157 ± 1.24, 7, 6–10
Accumulated dose of L-GBCA (mean) (mL)52.5 ± 21.63121.4 ± 38.69
52.0 ± 22.7652.8 ± 21.22132.0 ± 41.16102.5 ± 25.16
  • Note:—CE indicates contrast-enhanced; Subg., subgroup; DMT, disease-modifying therapy.