Table 1:

Baseline demographics at visit 2 and P values for association with concurrent carotid distensibility measurement^a

Variable	Full Cohort (n = 1402)	P Value for Association with Carotid Distensibility
Age (mean)	55.6 ± 5.3	<.001^d
Male (No.) (%)	571, 40.7	.214
Caucasian (No.) (%)	1,023, 73.0	.007^d
Hypertension (No.) (%) (n = 1396)	280, 20.1	<.001^d
Diabetes (No.) (%) (n = 1398)	71, 5.1	.265
History of myocardial infarction (No.) (%)	26, 1.9	.898
History of stroke (No.) (%)	10, 0.7	.602
Prevalent coronary heart disease (No.) (%)	16, 1.2	.297
Current cigarette smoking (No.) (%) (n = 1400)	206, 14.7	<.001^d
Current alcohol consumption (No.) (%) (n = 1400)	846, 60.4	.009^d
Body mass index (mean)	27.1 ± 4.6	<.001^d
LDL cholesterol (mean) (mg/dL) (n = 1376)	131.2 ± 35.0	.493
HDL cholesterol (mean) (mg/dL) (n = 1328)	49.3 ± 16.7	.067
Fasting blood glucose (mean) (mmol/L)	5.9 ± 1.6	.077
Antihypertensive in last 2 weeks (No.) (%) (n = 1397)	248, 17.8	<.001^d
Aspirin in last 2 weeks (No.) (%) (n = 1400)	632, 45.1	.369
Statin in last 2 weeks (No.) (%) (n = 1400)	29, 2.1	.651
Plaque in either carotid on ultrasound (No.) (%) (n = 1392)	310, 22.3	.270
Voltage of left ventricular leads on ECG (mean) (n = 1391)	1174.2 ± 525.4	<.001^d
WMH volume (mean) (mL)	17.5 ± 17.4
Total brain volume (mean) (mL) (n = 1397)^b	1015.8 ± 109.4
Ratio of WMH/TBV (mean) (%) (n = 1397)^b	1.7 ± 1.7
Mean systolic blood pressure (mm Hg)^c	135.0 ± 12.4
Mean systolic SD (mm Hg)^c	15.8 ± 4.2
Mean number of blood pressure readings^c	23.3 ± 3.1
Years between carotid ultrasound and MRI (mean)	21.5 ± 0.9

Note:—ECG indicates electrocardiography; HDL, high-density lipoprotein; LDL, low-density lipoprotein.
↵a Association tested with linear regression for continuous variables and Student t test for categoric variables.
↵b Derived from visit 5 MRI.
↵c Derived from all available blood pressure readings from visit 2 through visit 5.
↵d Significant.