Demographic and structural variables in healthy and midline abnormality groups

	Healthy Group (Avg ± SD)	Midline Group (Avg ± SD)	Total (Avg ± SD)	P
Age (yr)	11.7 ± 5.3	4.1 ± 5.5	7.9 ± 6.6	.001
Sex	n = 55 f (52%)	n = 52 f (50%)	n = 107 f (51%)	.78
MI present	n = 92 (88%)	n = 62 (60%)	n = 154 (74%)	.001
Morphology	n = 89 (n); 3(T)	n = 45 (n); 10(T); 7(t)	n = 134 (n); 13(T); 7(t)	.001
tr (mm)	1.5 ± 0.2	2 ± 0.2	1.7 ± 1	.002
ap (mm)	7.3 ± 2.3	6.8 ± 3.9	7 ± 3.1	.144
cc (mm)	6.7 ± 5.6	6.1 ± 3.5	6.4 ± 4.9	.202
Area (mm²)	42.9 ± 23.9	44.2 ± 48.9	43.2 ± 35.9	.458
Location	n = 84 (a/s); 6 (p/s); 2 (p/i)	n = 34 (a/s); 14 (p/s); 3 (p/i); 1 (a/i); 10 (all)	n = 118 (a/s); 20 (p/s); 5 (p/i); 1 (a/i); 10 (all)	.001
CC present	n = 105 (100%)	n = 70 (68%)	n = 175 (84%)	.001
Morphology	n = 105 (n)	n = 13 (n); 6 (h); 46 (h/d); 5 (d)	n = 118 (n); 6 (h); 46 (h/); (5d)	.001
Length (mm)	68.2 ± 7.6	39.9 ± 21.5	57 ± 20.2	.001
Genu (mm)	10.5 ± 2	7.4 ± 10	9.3 ± 6.6	.007
Body (mm)	5.7 ± 1.2	3.5 ± 2.2	4.9 ± 1.9	.001
Splen (mm)	10.3 ± 2	4.7 ± 2.9	8.4 ± 3.6	.001
Area (mm²)	546 ± 129	214 ± 199	415 ± 228	.001
AC present	n = 105 (100%)	n = 101 (98%)	n = 206 (99%)	.151
Morphology	n = 105 (n)	n = 41 (n); 53 (h); 7 (T)	n = 146 (n); 53 (h); 7 (T)	.001
tr (mm)	1.8 ± 0.4	3.9 ± 1.5	2.8 ± 1.5	.001
ap (mm)	2.6 ± 0.7	1.7 ± 1.1	2.2 ± 1	.001
cc (mm)	3.5 ± 1	2.2 ± 1.3	2.9 ± 1.3	.001
Area (mm²)	8.1 ± 3.8	4.4 ± 5.1	6.3 ± 4.9	.001
Septum pellucidum	n = 96 (n); 9 (c)	n = 13 (n); 7 (c); 47 (a); 36 (h)	n = 109 (n); 16 (c); 47 (a); 36 (h)	.001
Fornix	n = 105 (n)	n = 36 (n); 25 (a); 42 (h)	n = 141 (n); 25 (a); 42 (h)	.001
Hypothalamus	n = 105 (n)	n = 84 (n); 19 (IHA)	n = 189 (n); 19 (IHA)	.001
Hippocampus	n = 87 (n); 18 (u)	n = 11 (n); 88 (u); 2 (d); 2 (mts)	n = 98 (n); 106 (u); 2 (d); 2 (mts)	.001
Brain stem	n = 105 (n)	n = 67 (n); 18 (h); 18 (d)	n = 172 (n); 18 (h); 18 (d)	.001
Vermis	n = 105 (n)	n = 77 (n); 15 (h); 11 (d)	n = 182 (n); 15 (h); 11 (d)	.001
3rd Ventricle (mm)	2.8 ± 0.9	5.5 ± 3.3	4.1 ± 2.8	.001

Note:—Avg indicates average; tr, transverse diameter; ap, anteroposterior diameter; cc, craniocaudal diameter; CC, corpus callosum; Splen, splenium; AC, anterior commissure; n, normal; T, thick; t, thin; a/s, anterior/superior quadrant of 3rd ventricle; a/i, anterior-inferior; p/s, posterior-superior; p/i, posterior-inferior; all, all quadrants; h, hypoplastic; h/d, hypogenetic ± dysgenetic; d, dysgenetic/dysplastic; c, cavum; a, absent; IHA, interhypothalamic adhesion; u, under-rotated; mts, hippocampal sclerosis; f, female.