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Table 3: Regional gray matter volume reductions in patients with Angelman syndrome compared with controls based on voxel-based morphometry analysis^{^a}
Anatomic Region Number of Voxels in Each Cluster Peak Z Score Coordinates of Voxel of Maximal Statistical Significance (MNI Space)
Left putamen, pallidum, caudate nucleus 18,317 7.73 −21, 2, 12
 Right caudate nucleus 7.68 9, 11, 15
 Right putamen, pallidum 7.66 21, 5, 12
Right rectal gyrus 469 6.16 9, 34,−26
 Right superior orbital gyrus
 Left rectal gyrus
Left hippocampus 159 5.96 −20, −34, −0
 Left thalamus
 Left parahippocampal gyrus
 Left lingual gyrus
Left cerebellum (Crus 1, 2) 156 5.95 −51, −48, −36
Left cerebellum (VII, VIII, crus 2) 47 5.67 −46, −43, −50
Left rectal gyrus 28 5.58 −6, 36, −30
 Right rectal gyrus
 Left superior orbital gyrus
↵a Whole-brain analysis (FWE-corrected at P < .001; cluster threshold >20 voxels).