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Table 1: Demographic characteristics according to iCL status
iCL-Negative Subgroup (n = 16) iCL-Positive Subgroup (n = 55) P Value
No. (%) women 10/16 (63) 33/55 (43) .86^{^a}
Median age at MR imaging (yr)  (25th, 75th percentile) 27 (25–36.5) 40 (32–53) .003^{^b}
Median disease duration (mo)  (25th, 75th percentile) 15 (9–34.5) 77 (26–171) <.001^{^b}
Median EDSS score (25th, 75th percentile) 2 (1.25–3) 3.5 (2–4.5) .02^{^b}
MS phenotype (No.) (%) 
 Relapsing-remitting 15 (94) 39 (71) 
 Secondary-progressive 0 12 (22) 
 Primary-progressive 1 (6) 4 (7) .11^{^a}
↵a To compare, the Pearson χ² test was used.
↵b Significant difference.

	iCL-Negative Subgroup (n = 16)	iCL-Positive Subgroup (n = 55)	P Value
No. (%) women	10/16 (63)	33/55 (43)	.86^{^a}
Median age at MR imaging (yr) (25th, 75th percentile)	27 (25–36.5)	40 (32–53)	.003^{^b}
Median disease duration (mo) (25th, 75th percentile)	15 (9–34.5)	77 (26–171)	<.001^{^b}
Median EDSS score (25th, 75th percentile)	2 (1.25–3)	3.5 (2–4.5)	.02^{^b}
MS phenotype (No.) (%)
Relapsing-remitting	15 (94)	39 (71)
Secondary-progressive	0	12 (22)
Primary-progressive	1 (6)	4 (7)	.11^{^a}