1naresh
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Structure Figure Regions Connected Relevant Disorders Hypothesized Effects of Stimulation AL Fig 4B, -D (yellow) GPi, VOa PD and dystonia Improve dystonia and dyskinesia AS Fig 4B, -C (purple); Fig 3B, -C (blue) STN, GPi PD and dystonia Direct stimulation effect unknown ATR Fig 5A, -B (red) Thalamus, prefrontal cortex OCD Improve OCD DRTT Fig 1C, -D (red and green); Fig 4D (green) DN, RN, VIM/VOp, M1 ET and tremor-predominant PD Improve tremor, worsen ataxia FL Fig 2A; Fig 4D (red) GPi, VOa PD and dystonia Improve dystonia and parkinsonism FS Fig 3B, -C (Pink); Fig 4B, -C (red) STN, GPe PD and dystonia Direct stimulation effect unknown Hyperdirect pathway (limbic/associative) Fig 3A (cyan, yellow) STN, broad limbic and associative regions OCD Improve OCD Hyperdirect pathway (motor) Fig 3A (orange) STN, motor cortex PD Improve parkinsonism MMT Fig 6C (green) Mammillary body, ANT Epilepsy Decrease seizures MFB Fig 5A, -B (cyan) VTA, nucleus accumbens and olfactory cortex Depression (off-label use) Possibly worsens OCD TF Fig 2A Combination of FL, AL, and DRTT, thalamus PD, dystonia, ET Improve tremor vtaPP (formerly slMFB)a Fig 5A, -B (green) DN, VTA, SFG, MFG, and lateral OFC OCD Possibly improve OCD ANT Fig 6A–C Epilepsy Decrease seizures VIM Fig 1A–C; Fig 4D ET and tremor-predominant PD Improve tremor, worsen ataxia, dysarthria VOa/VOp Fig 1A, -B; Fig 4D ET and tremor-predominant PD Improve tremor, dystonia, worsen ataxia ZI Fig 1C; Fig 2A ET and tremor-predominant PD Improve tremor, worsen ataxia
Note:—DN indicates dentate nucleus; M1, primary motor cortex; MFG, middle frontal gyrus; OFC, orbitofrontal cortex; RN, red nucleus; SFG, superior frontal gyrus; VOa, ventralis oralis anterior; VOp, ventralis oralis posterior; VTA, ventral tegmental area; vtaPP, projection pathway from the ventral tegmental area.
↵a vtaPP (slMFB) likely represents misidentification of the limbic/associative hyperdirect pathway.