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Table 3: Intraindividual comparisons of model-free and pharmacokinetic parameters between stable and progression posttreatment glioma groups^{^a}
DCE Parameters Treatment-Related Change Group Progression Group P Value*^{^b} P Value+^{^b}
Gadobutrol Gadoterate Meglumine P Value Gadobutrol Gadoterate Meglumine P Value
Model-free method 
 IAUC30 3.43 ± 1.59 3.90 ± 1.84 .399 4.69 ± 3.24 4.88 ± 2.25 .870 .15 .34
 IAUC100 15.82 ± 7.88 17.91 ± 9.21 .446 20.55 ± 13.69 21.20 ± 9.51 .895 .22 .34
 IAUC200 15.80 ± 7.87 17.89 ± 9.20 .446 20.54 ± 13.67 21.18 ± 9.49 .896 .22 .34
 IAUC300 15.82 ± 7.88 17.91 ± 9.20 .445 20.56 ± 13.67 21.21 ± 9.50 .894 .22 .34
 IAUC400 15.79 ± 7.87 17.88 ± 9.18 .445 20.54 ± 13.66 21.17 ± 9.49 .897 .22 .34
 IAUC500 15.81 ± 7.87 17.90 ± 9.19 .445 20.55 ± 13.66 21.18 ± 9.50 .898 .22 .34
 IAUC600 15.82 ± 7.87 17.91 ± 9.20 .445 20.57 ± 13.66 21.20 ± 9.50 .897 .22 .34
 IAUC700 15.83 ± 7.87 17.92 ± 9.20 .445 20.57 ± 13.67 21.21 ± 9.51 .896 .22 .34
 IAUC800 15.83 ± 7.87 17.92 ± 9.20 .445 20.58 ± 13.67 21.21 ± 9.51 .896 .22 .34
 IAUC900 16.64 ± 8.11 18.29 ± 9.45 .651 19.78 ± 13.43 20.69 ± 8.71 .859 .51 .54
 IAUC1000 16.65 ± 8.11 18.30 ± 9.46 .651 19.79 ± 13.43 20.70 ± 8.72 .858 .51 .54
 IAUC1100 16.66 ± 8.11 18.31 ± 9.46 .651 19.79 ± 13.44 20.72 ± 8.73 .857 .51 .54
Pharmacokinetic method 
 K^trans (min^–1) 0.015 ± 0.007 0.016 ± 0.008 .531 0.017 ± 0.011 0.018 ± 0.007 .921 .45 .66
 K_ep (min^–1) 0.130 ± 0.041 0.132 ± 0.041 .878 0.121 ± 0.044 0.133 ± 0.044 .528 .58 .95
 V_e (%) 16.374 ± 9.615 16.220 ± 6.271 .952 20.169 ± 10.750 19.023 ± 9.085 .780 .31 .31
 V_p 1.045 ± 0.508 1.177 ± 0.591 .454 1.374 ± 0.916 1.408 ± 0.611 .915 .20 .29
 Wash-in rate 0.813 ± 0.521 0.220 ± 0.590 .002 0.845 ± 0.859 0.404 ± 0.738 .191 .86 .44
 Washout rate 0.0009 ± 0.0004 0.0015 ± 0.0016 .107 0.0013 ± 0.0012 0.0031 ± 0.0033 .091 .17 .08
↵a Data are means. P values are from paired t-tests.
↵b P* values and P+ values are from Student t tests between the treatment-related-change and tumor-progression groups for gadobutrol and gadoterate meglumine, respectively.