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Table 2: 
Intraindividual comparison of model-free and pharmacokinetic parameters between gadobutrol and gadoterate meglumine dynamic contrast-enhanced MR imaginga
DCE ParameterGadobutrolGadoterate MeglumineP Value
Model-free method
 IAUC303.91 ± 2.384.27 ± 2.02.517
 IAUC10021.50 ± 12.8223.41 ± 11.28.530
 IAUC20039.08 ± 23.3042.53 ± 20.57.533
 IAUC30056.68 ± 33.7761.68 ± 29.88.533
 IAUC40074.25 ± 44.2480.79 ± 39.17.534
 IAUC50091.84 ± 54.7199.91 ± 48.46.534
 IAUC600109.44 ± 65.19119.06 ± 57.76.534
 IAUC700127.04 ± 75.66138.21 ± 67.07.535
 IAUC800144.66 ± 86.13157.37 ± 76.37.535
 IAUC900166.69 ± 98.74179.04 ± 83.13.656
 IAUC1000184.76 ± 109.43198.43 ± 92.13.656
 IAUC1100202.85 ± 120.13217.84 ± 101.13.657
Pharmacokinetic method
 Ktrans (min–1)0.016 ± 0.0090.017 ± 0.008.592
 Kep (min–1)0.127 ± 0.0420.132 ± 0.041.594
 Ve (%)17.797 ± 10.05717.271 ± 7.436.813
 Vp1.168 ± 0.6741.263 ± 0.600.559
 Wash-in rate0.825 ± 0.6440.289 ± 0.634.013
 Washout rate0.0010 ± 0.00080.0021 ± 0.0025.024
  • ↵a Data area means. P values are from paired tests when the variables satisfied normality according to the Shapiro-Wilk test or from Wilcoxon-signed rank tests otherwise.