Supplemental Table 1:

Bivariate analysis of imaging and laboratory findings in patients with COVID-19 dichotomized by location at stroke onset

Variable	Median (IQR)	In-Hospital (No.) (%)	Out-of-Hospital (No.) (%)	P Value
Patients (No.)	86	41	45
Age (yr)
20–69 years of age	68 (60–76)	20 (48.8)	26 (57.8)	.403
Sex, male		26 (63.4)	22 (48.9)	.176
Imaging
Ischemic stroke		39 (95.1)	33 (73.3)	.006
Infarction, no hemorrhage		26 (63.4)	31 (68.9)	.001
Infarction with HT		5 (12.2)	1 (2.2)
Infarction and ICH		8 (19.5)	1 (2.2)
Pure ICH, no infarction		2 (4.9)	12 (26.8)
Multivascular territory infarction (n = 72)		22 (56.4)	11 (33.3)	.022
Deep vein thrombosis		12 (29.3)	1 (2.2)	.001
Laboratory values
White blood cell^{^a}
≥10.5 K/uL	9.7 (7.2–14.7)	25 (61.0)	12 (26.7)	.001
Lymphocytes^{^b}
<1.00 K/uL	0.6 (0.31–1.05)	37 (90.2)	25 (55.6)	.001
Hemoglobin^{^a}
<11.5 g/dL	12.3 (9.7–13.8)	19 (46.3)	16 (35.6)	.309
Platelets^{^a}
<150 K/uL	247 (152–335)	9 (22.0)	10 (22.2)	.976
aPTT^{^a,^c}
>36.3 seconds	30.9 (28.4–36.1)	13 (32.5)	7 (17.1)	.108
INR^{^a,^c}
>1.20	1.17 (1.07–1.31)	19 (48.7)	17 (39.5)	.403
D-dimer,^c 4× nl
>920 ng/mL	3060 (1064–24,211)	37 (92.5)	17 (54.8)	.001
C-reactive protein,^c 2× nl
>10.0 mg/L	17.5 (6.4–28.8)	30 (79.0)	14 (43.8)	.002
Ferritin,^c 4× nl
>1200 ng/mL	1382 (706–2424)	30 (79.0)	10 (31.1)	<.001
LDH,^c 2× nl
>484 U/L	536 (357–815)	27 (73.0)	12 (42.9)	.014
ALT,^c 2× nl
>90.0 U/L	50 (29–136)	32 (78.1)	17 (39.5)	<.001
Creatinine^c
>1.30 mg/dL	1.30 (0.93–2.81)	28 (70.0)	15 (34.1)	.001

Note:—HT indicates hemorrhagic transformation; ICH, intracranial hemorrhage; nl, upper limit of the normal value; aPTT, activated partial thromboplastin time; INR, international normalized ratio; LDH, lactate dehydrogenase; ALT, alanine aminotransferase; IQR, interquartile range.
↵a White blood cell count, hemoglobin, platelets, activated aPTT, and INR are from admission or at the time of consultation for stroke. Remaining laboratory values (except lymphocyte count) are the maximum level during the hospitalization.
↵b Lowest lymphocyte count during admission.
↵c Variable has missing values. The number and percentage (No.) (%) of patients with missing laboratory values are the following: aPTT (n = 5, 5.8%), INR (n = 4, 4.7%), D-dimer (n = 16, 18.6%), C-reactive protein (n = 16, 18.6%), ferritin (n = 16, 18.6%), LDH (n = 21, 24.4%), ALT, (n = 2, 2.3%), and creatinine (n = 2, 2.3%). All other variables have no missing values.