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Table 1: Sonographic features of thyroid nodules included in this study^{^a}
Characteristic Benign Nodules (n = 287) Malignant Nodules (n = 167) Total (n = 454) P Value
Diameter (mm) .011
 Mean [SD] 18.6 [SD, 10.7] 16.4 [SD, 7.5] 17.8 [SD, 9.7] 
 Range 10.0–73.0 10.0–48.0 10.0–73.0 
Internal content <.001
 Solid 166 (57.8) 151 (90.4) 317 (69.8) 
 Partially cystic 121 (42.2) 16 (9.6) 137 (30.2) 
 Cystic 0 0 0 
Echogenicity <.001
 Hypoechogenicity 67 (23.3) 142 (85.0) 209 (46.0) 
 Iso-/hyperechogenicity 220 (76.7) 25 (15.0) 245 (54.0) 
Shape .143
 Round-to-oval 278 (96.9) 157 (94.0) 435 (95.8) 
 Irregular 9 (3.1) 10 (6.0) 19 (4.2) 
Orientation <.001
 Parallel 267 (93.0) 80 (47.9) 347 (76.4) 
 Nonparallel 20 (7.0) 87 (52.1) 107 (23.6) 
Margin <.001
 Smooth 220 (76.7) 56 (33.5) 276 (60.8) 
 Spiculated/microlobulated 5 (1.7) 85 (50.9) 90 (19.8) 
 Ill-defined 62 (21.6) 26 (15.6) 88 (19.4) 
Calcification <.001
 None 256 (89.2) 49 (29.3) 305 (67.2) 
 Microcalcification 8 (2.8) 102 (61.1) 110 (24.2) 
 Macrocalcification 23 (8.0) 16 (9.6) 39 (8.6) 
Spongiform 0.534
 Absence 285 (99.3) 167 (100.0) 452 (99.6) 
 Presence 2 (0.7) 0 2 (0.4) 
CAD diagnosis <.001
 Possibly benign 235 (81.9) 31 (18.6) 266 (58.6) 
 Possibly malignant 52 (18.1) 136 (81.4) 188 (41.4) 
Radiologist diagnosis <.001
 Possibly benign 275 (95.8) 30 (18.0) 305 (67.2) 
 Possibly malignant 12 (4.2) 137 (82.0) 149 (32.8) 
↵a The numbers in parentheses are percentages.