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Table 1: Demographic, neuropsychological, and MR imaging findings of study participants
Study Participant Characteristic AD (n =  77) Healthy Control Participants (n = 77) P Value^{^b}
No. female (%) 47 (61) 44 (57) .62
Age, years,^{^a} 72 (8) 72 (8) .98
Age range, years 51–87 51–87 
MMSE^{^a} 22.03 (3.72) 27.57 (1.75) <.001
Global cortex volume, cm³^{^a} 329.63 (14.53) 394.04 (41.25) <.001
AD-signature regions volume, cm³^{^a} 54.81 (10.15) 70.28 (8.86) <.001
Global NAWM volume, cm³^{^a} 305.77 (63.71) 334.70 (52.52) .01
WM hyperintensities volume, cm³^{^a} 16.19 (17.69) 11.64 (18.01) .02
Fazekas grade 2 or 3, no. (%) 49 (63.7) 31 (40.3) 
Global cortex MTRs^{^a} 0.295 (0.016) 0.309 (0.008) <.001
AD-signature regions MTRs^{^a} 0.297 (0.018) 0.309 (0.009) <.001
Global NAWM MTRs^{^a} 0.384 (0.009) 0.388 (0.009) .003
WM hyperintensities MTRs^{^a} 0.322 (0.028) 0.350 (0.016) <.001
↵a Data are mean ± SDs.
↵b Pearson χ2 for nominal, Wilcoxon, and paired t test for continuous variables were applied.