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Table 4: Paired t test results for volumes reported by BraTumIA 1.2 and BraTumIA 2.0 (in mL)
Segmented Region Average Volume BraTumIA 1.2 Average Volume BraTumIA 2.0 Average Difference in Volumes (BraTumIA 2.0–BraTumIA 1.2)
Mean SD Mean SD Mean
Enhancing 25.2 17.6 23.9 17.1 –1.3^{^a}
Edema 95.6 36.4 92.2 35.1 –3.4^{^b}
Nonenhancing 3.02 3.04 2.69 2.43 –0.33
Necrotic 5.79 12.5 6.82 12.6 1.0^{^b}
Total tumor-related abnormality 130 53.4 126 50.0 –4^{^b}
Total nonenhancing tumor-related components 104 40.5 102 37.7 –2^{^c}
Nonenhancing non-necrotic tumor-related components 98.7 38.3 94.8 36.0 –3.9^{^b}
WM 544 50.5 547 53.5 3^{^c}
GM 596 54.8 610 56.1 14^{^a}
↵a P < .005 level.
↵b P < .01 level.
↵c P < .05 level.

Segmented Region	Average Volume BraTumIA 1.2		Average Volume BraTumIA 2.0		Average Difference in Volumes (BraTumIA 2.0–BraTumIA 1.2)
Segmented Region	Mean	SD	Mean	SD	Mean
Enhancing	25.2	17.6	23.9	17.1	–1.3^{^a}
Edema	95.6	36.4	92.2	35.1	–3.4^{^b}
Nonenhancing	3.02	3.04	2.69	2.43	–0.33
Necrotic	5.79	12.5	6.82	12.6	1.0^{^b}
Total tumor-related abnormality	130	53.4	126	50.0	–4^{^b}
Total nonenhancing tumor-related components	104	40.5	102	37.7	–2^{^c}
Nonenhancing non-necrotic tumor-related components	98.7	38.3	94.8	36.0	–3.9^{^b}
WM	544	50.5	547	53.5	3^{^c}
GM	596	54.8	610	56.1	14^{^a}