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Table 2: Results of diagnostic performance of 2 neuroradiologists in the detection of changes of optic neuritis on T2-weighted FLAIR, coronal CE-T1WI, and axial CE-T1WI of brain without and with the availability of postprocessed images that aimed to selectively accentuate the signal intensity of diseased optic nerves
Parameter Reader 1 P^{^a} Value Reader 2 P^{^a} Value Average
Before Processing After Processing Before Processing After Processing Before Processing After Processing
Sensitivity (FL) 56.7% 56.7% .34 53.3% 53.3% .31 55.0% 55.0%
Specificity (FL) 62.1% 89.7% .01 89.7% 93.1% .5 75.9% 91.4%
Accuracy (FL) 59.3% 72.9% .03 71.2% 72.9% .5 65.3% 72.9%
PPV (FL) 60.7% 85% NA 84.2% 88.9% NA 72.5% 86.9%
NPV (FL) 58.1% 66.7% NA 65% 65.9% NA 61.5% 66.3%
Sensitivity (CCE) 47.8% 56.5% .31 56.5% 56.5% .24 52.2% 56.5%
Specificity (CCE) 81.8% 100% .07 95.5% 100% .5 88.7% 100%
Accuracy (CCE) 64.4% 77.8% .04 75.5% 77.8% .5 69.9% 77.8%
PPV (CCE) 73.3% 100% NA 92.9% 100% NA 83.1% 100%
NPV (CCE) 60% 68.8% NA 67.7% 68.8% NA 63.9% 68.8%
Sensitivity (ACE) 20.0% 30.0% .22 13.3% 30.0% .07 16.7% 30.0%
Specificity (ACE) 86.2% 100% .07 100% 100% 0 93.1% 100.0%
Accuracy (ACE) 52.5% 64.4% .04 55.9% 64.4% .07 54.2% 64.4%
PPV (ACE) 60% 100% NA 100% 100% NA 80.0% 100%
NPV (ACE) 51% 58% NA 52.7% 58% NA 51.9% 58%
Note:—FL indicates FLAIR; CCE, coronal CE-T1WI; ACE, axial CE-T1WI; NPV, negative predictive value; NA, not applicable.
↵a One-tailed McNemar test.