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Estimates produced by the linear mixed-effects models for fold change and lesion velocity in the full and restricted cohorts
Fold ChangeLesion Velocity
Estimate95% CIPEstimate95% CIP
Full cohort
    Time0.01–0.03–0.04.7680.00–0.00–0.00.989
    Phenotype (progressive)–3.00–6.94–0.94.1420.340–0.10–0.77.136
    Time*phenotype (progressive)2.492.10–2.89<.0010.1000.05–0.14<.001
Restricted cohort
    Time0.01–0.06–0.08.7520.00–0.01–0.01.899
    Phenotype (progressive)–3.43–11.08–4.21.3860.15–0.47–0.78.632
    Time*phenotype (progressive)2.542.04–3.04<.0010.110.06–0.15<.001
  • Note:—Asterisk indicates the interaction between phenotype and time in the linear mixed effects model.