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Table 2: 
Automated measures of distance and area
MeasureHow to Measure
Biparietal widthIdentify most lateral sagittal slices of parietal GM (regionprops3)
For each GM voxel, calculate distance to voxels in opposite hemisphere
Calculate maximum distance
Interhemispheric distanceCalculate distance from each voxel of superior frontal gyrus label in left hemisphere to each voxel label in right hemisphere (bwmorph3, bwdist)
Derive minimum distance
Callosal thicknessCombine 2D corpus callosum segmentation of the 11 most medial slices
Increase resolution (imresize) and improve mask (bwmorph3, bwmorph)
Derive skeleton (bwskel); for every voxel, calculate normal vector, identify intersection with borders of segmentation (points2contour, polyfit)
Derive distance between upper/lower segmentation borders for every voxel
Apply smoothing (nanfastsmooth), make 3 divisions
Obtain 97th percentile for each division (prctile)
Transcerebellar diameterModel cerebellum segmentation as 3D ellipsoid (bwmorph3, regionprops3)
Calculate length of principal axis (regionprops3)
Lateral ventricular dilationIdentify coronal slice at level of ventricular atrium (regionprops3): find maximum surface area using ventricle label (bwmorph, regionprops)
Model 2D ventricle as ellipse, calculate length of minor axes (regionprops)
Deep grey matter areaIdentify axial slice: centroid of caudate, thalamus, and lentiform nucleus (bwmorph, regionprops)
Combine labels to calculate area (regionprops)
  • Note:—Matlab package used is provided in brackets.