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Table 1: 
Clinicodemographic characteristics of the studied population, along with MR imaging–derived global brain volumesa
Site 1 (n = 500)Site 2 (n = 104)P Value 
(Site 1 vs Site 2)
Age (mean) (yr)37.5 (SD, 10.9)38.3 (SD, 9.8).49
Female sex (No.) (%)349 (69.8)80 (76.9).16
Secondary-progressive course (No.) (%)72 (14.4)20 (19.2).23
DD (mean) (yr)9.3 (SD, 8.1)9.2 (SD, 8.5).83
EDSS (median) (IQR)2.5 (2.0–4.0)2.0 (1.5–4.0).03
TLV (mean) (mL)10.6 (SD, 13.4)7.2 (SD, 8.6).05
WBV (mean) (mL)1026.1 (SD, 116.3)1042.6 (SD, 117.4).48
  • Note:—TLV indicates total lesion volume.
  • ↵a Between-group differences regarding MR imaging measures are adjusted for age, sex, and estimated total intracranial volume.