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Table 3: Exploratory analysis of spatial habitats for predicting TTP in patients with PCNSL
Spatial Tumor Habitats TTP
Hazard Ratio^{^a} 95% CI P Value
No. of voxels (20,000 voxels) 
 Hypervascular cellular habitat 1.39 0.29–6.44 .29
 Hypovascular cellular habitat 2.83 1.20–6.65 .017
 Hypovascular hypocelluar habitat 2.03 0.58–7.15 .27
Voxel fraction (%) 
 Hypervascular cellular habitat 0.88 0.04–20.97 .83
 Hypovascular cellular habitat 2.07 0.29–14.83 .46
 Hypovascular hypocelluar habitat 0.46 0.05–4.01 .48
ADC 0.98 0.95–1.01 .16
CBV 0.80 0.45–1.32 .38
↵a Hazard ratios reported here indicate the relative change in hazard that a 10-unit (20,000 voxels) increase in each imaging parameter incurs.

Spatial Tumor Habitats	TTP
Spatial Tumor Habitats	Hazard Ratio^{^a}	95% CI	P Value
No. of voxels (20,000 voxels)
Hypervascular cellular habitat	1.39	0.29–6.44	.29
Hypovascular cellular habitat	2.83	1.20–6.65	.017
Hypovascular hypocelluar habitat	2.03	0.58–7.15	.27
Voxel fraction (%)
Hypervascular cellular habitat	0.88	0.04–20.97	.83
Hypovascular cellular habitat	2.07	0.29–14.83	.46
Hypovascular hypocelluar habitat	0.46	0.05–4.01	.48
ADC	0.98	0.95–1.01	.16
CBV	0.80	0.45–1.32	.38