Table 3:

Association of PMA and postnatal age with metabolites adjusted for clinical factors^{^a}

	Age Parameter	Cerebellum (β, P Value)	Right Basal Ganglia (β, P Value)	Right Frontal Lobe (β, P Value)
Metabolite
GABA+	Model 1^{^b}: PMA (wk)	0.02, NS	0.02, NS	0.06, .11
GABA+	Model 2^{^c}: postnatal age (wk)	–0.01, NS	0.10, NS	0.09, NS
Glx	PMA	0.25, .09	0.22, .003	0.3, .005
Glx	Postnatal age	0.03, NS	0.15, .13	0.14, NS
Cr	PMA	0.29, .002	0.11, .11	0.20, <.001
Cr	Postnatal age	0.15, NS	0.06, NS	0.14, .06
Cho	PMA	0.06, .095	0.02, NS	0.05, .016
Cho	Postnatal age	0.03, NS	0.01, NS	0.03, NS
NAA	PMA	0.22, .002	0.23, <.001	0.36, <.001
NAA	Postnatal age	0.14, .11	0.17, .06	0.27, .007
Metabolite ratios
Glx/Cho	PMA	0.02, NS	0.10, .003	0.09, .02
Glx/Cho	Postnatal age	–0.02, NS	0.08, .038	0.06, NS
GABA+/Cho	PMA	–0.01, NS	0.02, NS	0.02, NS
GABA+/Cho	Postnatal age	-0.02, NS	0.02, NS	0.03, .10
NAA Cho	PMA	0.05, .001	0.13, <.001	0.13, <.001
NAA Cho	Postnatal age	0.04, .04	0.08, .002	0.10, <.001
Cr/Cho	PMA	0.05, <.001	0.05, .12	0.06, <.001
Cr/Cho	Postnatal age	0.02, .14	0.06, .13	0.05, .015
GABA+/Glx	PMA	–0.02, NS	–0.02, .11	–0.01, NS
GABA+/Glx	Postnatal age (wk)	0.00, NS	–0.01, NS	0.00, NS

↵a Metabolites are the following: n = 38 for the cerebellum, n = 30 for the right basal ganglia, and n = 38 for the right frontal lobe. Metabolite ratios were the following: cerebellum (n = 51), right basal ganglia (n = 36), and left frontal lobe (n = 48).
↵b Linear regression model 1: adjusted for PMA, sex, and mode of delivery.
↵c Linear regression model 2: adjusted for postnatal age, gestational age, sex, and mode of delivery.