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Table 3: Microstructure metrics and fiber statistics of focal WM lesions and whole-brain WM^{^a}
WM Lesion ROIs Whole-Brain WM
MS HC P Value^{^b} MS HC P Value^{^b}
DTI 
 FA 0.35 (SD, 0.06) 0.41 (SD, 0.06) .010 0.39 (SD, 0.02) 0.41 (SD, 0.01) .655
 MD 0.92 (SD, 0.17) 0.74 (SD, 0.04) <.001 0.76 (SD, 0.06) 0.74 (SD, 0.03) .334
 AD 1.28 (SD, 0.21) 1.08 (SD, 0.04) .002 1.28 (SD, 0.03) 1.07 (SD, 0.03) .327
 RD 0.77 (SD, 0.15) 0.57 (SD, 0.06) <.001 0.59 (SD, 0.03) 0.56 (SD, 0.02) .555
NODDI 
 f_icvf 0.55 (SD, 0.12) 0.69 (SD, 0.05) .001 0.69 (SD, 0.06) 0.71 (SD, 0.05) .914
 ODI 0.30 (SD, 0.07) 0.34 (SD, 0.05) .109 0.34 (SD, 0.02) 0.33 (SD, 0.02) .334
Fiber 
 No. 6308 (1319, 11,641) 7582 (1204, 13,494) .780 199,230 (SD, 46,819) 208,260 (SD, 60,599) .905
 Length 35.11 (SD, 12.21) 39.73 (SD, 8.32) .211 22.39 (SD, 6.24) 22.73 (SD, 7.21) .846
↵a Data are mean (SD) except for the number of fibers through lesion areas, which are median (range).
↵b False discovery rate–corrected P values.