1naresh
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Study/No. of Participants GRADE Rating Follow-Up Period OutcomeHealth Care Use or Cost, Outcome Measure EffectOR, 95% CI, or Rate Ratio (P Value) Jarvik et al, 202021N = 238,886c Moderate Short-term Written opioid prescription OR = 0.95 (0.90–0.99)b Marcum et al, 202125N = 170,680c Moderate Short-term New prescription for nonopioid pain-related medicationsd OR = 1.02 (0.97–1.08)b Jarvik et al, 202021N = 238,886c Moderate Long-term Written opioid prescription OR = 0.95 (0.91–1.00)b Suri et al, 202126N = 238,886c Moderate Long-term Nonsurgical procedureseAny spine surgery OR = 1.01 (0.93–1.09)bOR = 0.99 (0.91–1.07)b Weeks et al, 202024N = 6904 Very low Long-term Primary care visitsChiropractic care visitsPhysical therapy care visitsSpecialty care visitsNerve-conduction testsMR imaging testingNon-MR imagingFacet injectionOn an opioidOn a muscle relaxantNonfusion spine surgery Rate ratio = 0.86 P = NSfRate ratio = 1.37 P = .05f Rate ratio = 1.19 P = NSf Rate ratio = 0.95 P = NSf Rate ratio = 0.57 P = .05f Rate ratio = 0.89 P = NSf Rate ratio = 0.73 P = .04f Rate ratio = 0.71 P = .02f Rate ratio = 0.98 P = NSf Rate ratio = 0.82 P = NSf Rate ratio = 0.71 P = NSf Fusion spine surgery Rate ratio = 0.76 P = NSf Weeks et al, 202024N = 6904 Very low Long-term Cost, total spine-related per member per month expenditures Rate ratio = 0.85 P = NSf
Note:—NS indicates not significant.
↵a Dichotomous outcomes are shown. A rate ratio of <1 represents an effect in favor of the intervention group.
↵b Adjusted for health system, clinic size, age range, sex, imaging technique, Charlson Comorbidity Index category, seasonality, and health-specific trends. Results of opioid prescription additionally adjusted for prior opioid use. Results of nonsurgical procedures additionally adjusted for nonsurgical use in the year preceding index imaging.
↵c Articles reporting outcomes from the same study.
↵d Nonopioid, pain-related medications including skeletal muscle relaxants, NSAIDs, gabapentenoids, tricyclic antidepressants, and benzodiazepines.
↵e Procedures include lumbosacral epidural steroid injection, facet joint injection, facet join radiofrequency ablation, or sacroiliac injection.
↵f Adjusted for age, sex, line of business, deductible, and forecasted risk score at the time of first MR imaging.