Table 2:

Baseline characteristics of “older with larger brains” men and older men in CADASIL^{^a}

	Older with Larger Brains Men (n = 22)	Older Men (n = 23)	P Value
Age (mean) (range) (yr)	59.3 (SD, 8.5) (43.6–77.8)	56.4 (SD, 10.7) (42.1–79.4)	.12
Genetic profile^{^b}			.92
Mutation in EGFR domains 1–6	15 (68%)	17 (74%)
Mutation in EGFR domains 7–34	7 (32%)	6 (26%)
Level of education^{^b} (yr)			.30
1–3	2 (9%)	6 (26%)
4–6	13 (59%)	10 (43%)
7	7 (32%)	7 (30%)
mRS^{^b}^,^{^c} (median) (IQR)	1 (0–2)	3 (1–5)	.009
MDRS^{^d} (mean)	136.2 (SD, 8.7)	120.8 (SD, 28.5)	.04
MMSE^{^e} (mean)	28.2 (SD, 2.2)	22.9 (SD, 6.7)	.45
TMTAT^{^f} (mean)	52.6 (SD, 30.3)	42.9 (SD, 20.3)	.004
TMTBT^{^g} (mean)	125.4 (SD, 87.0)	142.0 (SD, 97.7)	.003
Normalized brain volume (mean) (cm³)	1043.5 (SD, 30.8)	944.2 (SD, 40.1)	<.001
Annual PBVC (%)	−0.4 (0.7)	−2.0 (0.7)	<.001
Normalized WMH volume (%)	0.1 (0.1)	0.1 (0.0)	.03
No. of lacunes	6.8 (7.7)	10.6 (8.0)	.01
No. of microbleeds	11.0 (23.4)	8.6 (18.2)	.36

Note:—PBVC indicates percentage of brain volume change
↵^aCharacteristics of older men with larger brains and older men were compared with appropriate methods, depending on variable type and distribution (Mann-Whitney test by default or χ² test of independence for categoric variables).
↵^bComparisons performed using the χ² test of independence.
↵^cOn 22 older with men larger brains and 21 older men.
↵^dOn 20 and 12 patients, respectively.
↵^eOn 22 and 16 patients, respectively.
↵^fOn 19 and 9 patients, respectively.
↵^gOn 17 and 9 patients, respectively.