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Table 3: Recommended imaging sequences for baseline imaging and ARIA monitoring examinations based on clinical trial experience and current guidelines^{^a}
Minimal Recommended Notes
Field strength 1.5T 3T Use of a consistent field strength for serial imaging of a given patient is important; imaging may be performed at 1.5T if a patient is not a candidate for imaging at 3T or 3T scanners are not available at a site
ARIA-E detection 2D-FLAIR 2D- or 3D-FLAIR Either 2D or 3D is acceptable, whichever can be performed with consistent quality and optimal CSF suppression
ARIA-H detection T2*-GRE T2*-GRE (±SWI) Recommendations for enrollment and dose suspension are based on T2*-GRE detection of blood products; SWI may also be performed for confirmation and may be of value to gather data going forward
Infarct assessment DWI DWI DWI required to differentiate ARIA from acute/subsacute infarct and identification of incidental infarcts
↵a Additional optional sequences may be added per individual site preference.