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Table 2: Morphologic MR imaging characteristics
BRAF V600E-Mut (n = 11) BRAF-KIAA Rearrangement (n = 20) Wild-Type BRAF (n = 8) NF1 (n = 12) P Value
Location (No.) (%) 
 Cerebral hemisphere 3 (27.3%) 3 (15%) 1 (12.5%) 1 (8.3%)  .15
 Cerebellum 1 (9.1%) 7 (35%) 5 (62.5%) 2 (16.7%) 
 Brainstem 2 (18.2%) 6 (30%) 0 (0%) 2 (16.7%) 
 Diencephalon 5 (45.5%) 4 (20%) 2 (25%) 7 (58.3%) 
Well-defined margins (yes/no) 9.1% (1/10) 45.0% (9/11) 62.5% (5/3) 16.6% (2/10) .03^{^a}^,^{^b}^,^{^c}
Hemorrhagic components or calcifications (yes/no)^* 0% (0/8) 15.3% (2/11) 62.5% (5/3) 0% (0/6) .005^{^b}^,^{^c}^,^{^f}
Cystic components (yes/no) 45.4% (5/6) 60% (12/8) 87.5% (7/1) 0% (0/12) .001^{^c}^,^{^d}^,^{^e}
Contrast enhancement (yes/no) 81.8% (9/2) 85% (17/3) 100% (8/0) 50% (6/6) .04^{^c}^,^{^d}
Note:—Mut indicates mutant. Each superscript letter represents a significant difference between 2 categories.
↵a BRAF V600E-mutant versus BRAF-KIAA rearrangement.
↵b BRAF V600E-mutant versus BRAF wild-type.
↵c BRAF wild-type versus NF1.
↵d BRAF V600E-mutant versus NF1.
↵e BRAF-KIAA rearrangement versus NF1.
↵f BRAF wild-type versus BRAF-KIAA rearrangement.
↵* Evaluated only when SWI/T2* or CT scans were available (n = 35).