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Comparison of 3T versus 7T MRS in visualization of metabolic markers in HGGs^a
3T 7T
SNR Lower (–) Higher (+)
Spatial resolution Lower (–) Higher (+)
Resolution of overlapping resonances (ie, PC vs GPC, Lac vs lipids, 2HG vs Glu, Gln, GABA, possibly Glu vs Gln) Poorer (–) Better (+)
Range of metabolites Narrower (–) Wider (+)
Uncertainty values of metabolite concentrations Greater (–) Smaller (+)
Differentiation of IDH1/IDH2 gliomas vs wild-type gliomas Less specific (–) More specific (+)
B₀ inhomogeneity Lower (+) Higher (–)
B₁ inhomogeneity Lower (+) Higher (–)
RF power deposition (SAR) Lower (+) Higher (–)
CSL errors Less frequent (+) More frequent (–)
Susceptibility artifacts Less frequent (+) More frequent (–)
T1 relaxation time Shorter (+) Longer (–)
T2 relaxation time Longer (+) Shorter (–)
RF transmit body coils More accessible (+) Inaccessible (–)
Metal hardware (ie, titanium plates placed during craniotomies) Safe (+) Contraindicated (–)
Note:—CSL indicates chemical shift localization errors; (+), positive features; (–), negative features.
↵^aThe assets and drawbacks of 7T MRS compared with 3T MRS are delineated.