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<meta name="DC.Title" content="FLAIR and Diffusion MRI Signals Are Independent Predictors of White Matter Hyperintensities" />
<meta name="DC.Identifier" content="10.3174/ajnr.A3146" />
<meta name="DC.Date" content="2013-01-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: WMH, associated with cognitive decline and cardiovascular risk factors, may represent only the extreme end of a more widespread continuous WM injury process that progresses during aging and is poorly understood. We investigated the ability of FLAIR and DTI to characterize the longitudinal course of WMH development.

MATERIALS AND METHODS: One hundred nineteen participants (mean age, 74.5 ± 7.4), including cognitively healthy elders and subjects diagnosed with Alzheimer disease and mild cognitive impairment, received a comprehensive clinical evaluation and brain MR imaging, including FLAIR and DTI on 2 dates. The risk for each baseline normal-appearing WM voxel to convert into WMH was modeled as a function of baseline FA (model M1) and both baseline FA and standardized FLAIR (M2). Sensitivity, specificity, accuracy, and AUC for predicting conversion to WMH were compared between models.

RESULTS: Independent of clinical diagnosis, lower baseline FA ( P &lt; .001, both models) and higher baseline FLAIR intensity ( P &lt; .001, M2) were independently associated with increased risk for conversion from normal WM to WMH. M1 exhibited higher sensitivity but lower specificity, accuracy, and AUC compared with M2.

CONCLUSIONS: These findings provide further evidence that WMH result from a continuous process of WM degeneration with time. Stepwise decreases in WM integrity as measured by both DTI and FLAIR were independently associated with stepwise increases in WMH risk, emphasizing that these modalities may provide complementary information for understanding the time course of aging-associated WM degeneration.

AD
:   Alzheimer disease
AUC
:   area under the receiver operating characteristic analysis curve
CN
:   cognitively healthy
FA
:   fractional anisotropy
M1
:   first logistic regression model
M2
:   second logistic regression model
MCI
:   mild cognitive impairment
MDT
:   minimal deformation template
nFA
:   baseline normalized FA
nFL
:   baseline normalized FLAIR
OR
:   odds ratio
WMH
:   white matter hyperintensities" />
<meta name="DC.Contributor" content="P. Maillard" />
<meta name="DC.Contributor" content="O. Carmichael" />
<meta name="DC.Contributor" content="D. Harvey" />
<meta name="DC.Contributor" content="E. Fletcher" />
<meta name="DC.Contributor" content="B. Reed" />
<meta name="DC.Contributor" content="D. Mungas" />
<meta name="DC.Contributor" content="C. DeCarli" />
<meta name="article:published_time" content="2013-01-01" />
<meta name="article:section" content="Brain" />
<meta name="citation_title" content="FLAIR and Diffusion MRI Signals Are Independent Predictors of White Matter Hyperintensities" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;WMH, associated with cognitive decline and cardiovascular risk factors, may represent only the extreme end of a more widespread continuous WM injury process that progresses during aging and is poorly understood. We investigated the ability of FLAIR and DTI to characterize the longitudinal course of WMH development.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;One hundred nineteen participants (mean age, 74.5 ± 7.4), including cognitively healthy elders and subjects diagnosed with Alzheimer disease and mild cognitive impairment, received a comprehensive clinical evaluation and brain MR imaging, including FLAIR and DTI on 2 dates. The risk for each baseline normal-appearing WM voxel to convert into WMH was modeled as a function of baseline FA (model M1) and both baseline FA and standardized FLAIR (M2). Sensitivity, specificity, accuracy, and AUC for predicting conversion to WMH were compared between models.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;Independent of clinical diagnosis, lower baseline FA (&lt;i&gt;P&lt;/i&gt; &amp;lt; .001, both models) and higher baseline FLAIR intensity (&lt;i&gt;P&lt;/i&gt; &amp;lt; .001, M2) were independently associated with increased risk for conversion from normal WM to WMH. M1 exhibited higher sensitivity but lower specificity, accuracy, and AUC compared with M2.&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;These findings provide further evidence that WMH result from a continuous process of WM degeneration with time. Stepwise decreases in WM integrity as measured by both DTI and FLAIR were independently associated with stepwise increases in WMH risk, emphasizing that these modalities may provide complementary information for understanding the time course of aging-associated WM degeneration.&lt;/p&gt;" />
<meta name="citation_journal_title" content="American Journal of Neuroradiology" />
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<meta name="citation_publication_date" content="2013/01/01" />
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<meta name="citation_issn" content="0195-6108" />
<meta name="citation_issn" content="1936-959X" />
<meta name="citation_doi" content="10.3174/ajnr.A3146" />
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<meta name="citation_author" content="P. Maillard" />
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<meta name="citation_author_institution" content="bDepartment of Neurology and Center for Neuroscience (P.M., O.C., E.F., B.R., D.M., C.D.), University of California, Davis, Davis, California" />
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<meta name="citation_author_institution" content="aFrom the Imaging of Dementia and Aging Laboratory (P.M., O.C., E.F., B.R., D.M., C.D.)" />
<meta name="citation_author_institution" content="bDepartment of Neurology and Center for Neuroscience (P.M., O.C., E.F., B.R., D.M., C.D.), University of California, Davis, Davis, California" />
<meta name="citation_author" content="D. Harvey" />
<meta name="citation_author_institution" content="cDivision of Biostatistics (D.H., B.R., D.M., C.D.), Department of Public Health Sciences, School of Medicine, University of California, Davis, Davis, California." />
<meta name="citation_author" content="E. Fletcher" />
<meta name="citation_author_institution" content="aFrom the Imaging of Dementia and Aging Laboratory (P.M., O.C., E.F., B.R., D.M., C.D.)" />
<meta name="citation_author_institution" content="bDepartment of Neurology and Center for Neuroscience (P.M., O.C., E.F., B.R., D.M., C.D.), University of California, Davis, Davis, California" />
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<meta name="citation_author_institution" content="aFrom the Imaging of Dementia and Aging Laboratory (P.M., O.C., E.F., B.R., D.M., C.D.)" />
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<meta name="citation_reference" content="citation_journal_title=The British Journal of Psychiatry;citation_journal_title=Br. J. Psychiatry;citation_author=J. O'Brien;citation_author=P. Desmond;citation_author=D. Ames;citation_title=A magnetic resonance imaging study of white matter lesions in depression and Alzheimer's disease [published erratum appears in Br J Psychiatry 1996 Jun;168:792];citation_pages=477-485;citation_volume=168;citation_year=1996;citation_issue=4;citation_issn=0007-1250;citation_pmid=8730945;citation_doi=10.1192/bjp.168.4.477" />
<meta name="citation_reference" content="citation_journal_title=Neuron;citation_journal_title=Neuron;citation_author=RL. Buckner;citation_title=Memory and executive function in aging and AD: multiple factors that cause decline and reserve factors that compensate.;citation_pages=195-208;citation_volume=44;citation_year=2004;citation_issue=1;citation_pmid=15450170;citation_doi=10.1016/j.neuron.2004.09.006" />
<meta name="citation_reference" content="citation_journal_title=Archives of Neurology;citation_journal_title=Arch Neurol;citation_author=C. DeCarli;citation_author=BL. Miller;citation_author=GE. Swan;citation_title=Cerebrovascular and Brain Morphologic Correlates of Mild Cognitive Impairment in the National Heart, Lung, and Blood Institute Twin Study;citation_pages=643-647;citation_volume=58;citation_year=2001;citation_issue=4;citation_issn=0003-9942;citation_pmid=11295996;citation_doi=10.1001/archneur.58.4.643" />
<meta name="citation_reference" content="citation_journal_title=Journal of Cognitive Neuroscience;citation_journal_title=J. Cogn. Neurosci.;citation_author=CW. Nordahl;citation_author=C. Ranganath;citation_author=AP. Yonelinas;citation_title=White matter changes compromise prefrontal cortex function in healthy elderly individuals.;citation_pages=418-429;citation_volume=18;citation_year=2006;citation_issue=3;citation_issn=0898-929X;citation_pmid=16513006;citation_doi=10.1162/jocn.2006.18.3.418" />
<meta name="citation_reference" content="citation_journal_title=Neuropsychologia;citation_journal_title=Neuropsychologia;citation_author=CW. Nordahl;citation_author=C. Ranganath;citation_author=AP. Yonelinas;citation_title=Different mechanisms of episodic memory failure in mild cognitive impairment.;citation_pages=1688-1697;citation_volume=43;citation_year=2005;citation_issue=11;citation_pmid=16009250;citation_doi=10.1016/j.neuropsychologia.2005.01.003" />
<meta name="citation_reference" content="citation_journal_title=Neurology;citation_author=M. Yoshita;citation_author=E. Fletcher;citation_author=D. Harvey;citation_title=EXTENT AND DISTRIBUTION OF WHITE MATTER HYPERINTENSITIES IN NORMAL AGING, MCI, AND AD;citation_pages=2192-98;citation_volume=67;citation_year=2006;citation_doi=10.1212/01.wnl.0000249119.95747.1f" />
<meta name="citation_reference" content="citation_journal_title=Neurology;citation_author=DY. Lee;citation_author=E. Fletcher;citation_author=O. Martinez;citation_title=REGIONAL PATTERN OF WHITE MATTER MICROSTRUCTURAL CHANGES IN NORMAL AGING, MCI, AND AD;citation_pages=1722-28;citation_volume=73;citation_year=2009;citation_doi=10.1212/WNL.0b013e3181c33afb" />
<meta name="citation_reference" content="citation_journal_title=Neurology;citation_author=RA. Charlton;citation_author=TR. Barrick;citation_author=DJ. McIntyre;citation_pages=217-22;citation_volume=66;citation_year=2006;citation_doi=10.1212/01.wnl.0000194256.15247.83" />
<meta name="citation_reference" content="citation_journal_title=J Neurol Neurosurg Psychiatry;citation_author=RA. Charlton;citation_author=F. Schiavone;citation_author=TR. Barrick;citation_title=Diffusion tensor imaging detects age related white matter change over a 2 year follow-up which is associated with working memory decline;citation_volume=81;citation_year=2010;citation_pmid=19710050;citation_doi=10.1136/jnnp.2008.167288" />
<meta name="citation_reference" content="citation_journal_title=Archives of Neurology;citation_journal_title=Arch Neurol;citation_author=R. Au;citation_author=JM. Massaro;citation_author=PA. Wolf;citation_title=Association of White Matter Hyperintensity Volume With Decreased Cognitive Functioning: The Framingham Heart Study;citation_pages=246-250;citation_volume=63;citation_year=2006;citation_issue=2;citation_issn=0003-9942;citation_pmid=16476813;citation_doi=10.1001/archneur.63.2.246" />
<meta name="citation_reference" content="citation_journal_title=Journal of neurology;citation_journal_title=J Neurol;citation_author=EC. van Straaten;citation_author=D. Harvey;citation_author=P. Scheltens;citation_title=Periventricular white matter hyperintensities increase the likelihood of progression from amnestic mild cognitive impairment to dementia.;citation_pages=1302-1308;citation_volume=255;citation_year=2008;citation_issue=9;citation_pmid=18825439;citation_doi=10.1007/s00415-008-0874-y" />
<meta name="citation_reference" content="citation_journal_title=Neurology;citation_author=S. Debette;citation_author=S. Seshadri;citation_author=A. Beiser;citation_pages=461-68;citation_volume=77;citation_year=2011;citation_doi=10.1212/WNL.0b013e318227b227" />
<meta name="citation_reference" content="citation_journal_title=Stroke;citation_author=S. Debette;citation_author=A. Beiser;citation_author=C. Decarli;citation_title=Association of MRI markers of vascular brain injury with incident stroke, mild cognitive impairment, dementia, and mortality: the Framingham Offspring Study;citation_volume=41;citation_year=2010;citation_pmid=20167919;citation_doi=10.1161/STROKEAHA.109.570044" />
<meta name="citation_reference" content="citation_journal_title=Journal of hypertension;citation_journal_title=J Hypertens;citation_author=B. Neal;citation_author=S. MacMahon;citation_title=PROGRESS (perindopril protection against recurrent stroke study):  rationale and design. PROGRESS Management Committee [corrected].;citation_pages=1869-1873;citation_volume=13;citation_year=1995;citation_issue=12 pt 2;citation_pmid=8903669;citation_doi=10.1097/00004872-199512010-00068" />
<meta name="citation_reference" content="citation_journal_title=Journal of hypertension. Supplement :  official journal of the International Society of Hypertension;citation_journal_title=J Hypertens Suppl;citation_author=C. Tzourio;citation_author=C. Anderson;citation_title=Blood pressure reduction and risk of dementia in patients with stroke: rationale of the dementia assessment in PROGRESS (Perindopril Protection Against Recurrent Stroke Study). PROGRESS Management Committee.;citation_pages=S21-S24;citation_volume=18;citation_year=2000;citation_issue=1;citation_pmid=10939786" />
<meta name="citation_reference" content="citation_journal_title=Stroke;citation_author=P. Maillard;citation_author=E. Fletcher;citation_author=D. Harvey;citation_title=White matter hyperintensity penumbra;citation_volume=42;citation_year=2011;citation_pmid=21636811;citation_doi=10.1161/STROKEAHA.110.609768" />
<meta name="citation_reference" content="citation_journal_title=NeuroImage;citation_journal_title=Neuroimage;citation_author=W. Wen;citation_author=P. Sachdev;citation_title=The topography of white matter hyperintensities on brain MRI in healthy 60- to 64-year-old individuals.;citation_pages=144-154;citation_volume=22;citation_year=2004;citation_issue=1;citation_pmid=15110004;citation_doi=10.1016/j.neuroimage.2003.12.027" />
<meta name="citation_reference" content="citation_journal_title=Stroke;citation_author=DY. Lee;citation_author=E. Fletcher;citation_author=O. Martinez;citation_title=Vascular and degenerative processes differentially affect regional interhemispheric connections in normal aging, mild cognitive impairment, and Alzheimer disease;citation_volume=41;citation_year=2010;citation_pmid=20595668;citation_doi=10.1161/STROKEAHA.110.582163" />
<meta name="citation_reference" content="citation_journal_title=Neuroscience and biobehavioral reviews;citation_journal_title=Neurosci Biobehav Rev;citation_author=E. Sullivan;citation_author=A. Pfefferbaum;citation_title=Diffusion tensor imaging and aging.;citation_pages=749-761;citation_volume=30;citation_year=2006;citation_issue=6;citation_pmid=16887187;citation_doi=10.1016/j.neubiorev.2006.06.002" />
<meta name="citation_reference" content="citation_journal_title=Journal of Alzheimer's disease :  JAD;citation_journal_title=J Alzheimers Dis;citation_author=SJ. Teipel;citation_author=T. Meindl;citation_author=M. Wagner;citation_title=Longitudinal changes in fiber tract integrity in healthy aging and mild cognitive impairment: a DTI follow-up study.;citation_pages=507-522;citation_volume=22;citation_year=2010;citation_issue=2;citation_pmid=20847446" />
<meta name="citation_reference" content="citation_journal_title=Developmental neuropsychology;citation_journal_title=Dev Neuropsychol;citation_author=EV. Sullivan;citation_author=T. Rohlfing;citation_author=A. Pfefferbaum;citation_title=Longitudinal study of callosal microstructure in the normal adult aging brain using quantitative DTI fiber tracking.;citation_pages=233-256;citation_volume=35;citation_year=2010;citation_issue=3;citation_pmid=20446131;citation_doi=10.1080/87565641003689556" />
<meta name="citation_reference" content="citation_journal_title=Eur J Radiol;citation_author=YW. Cheng;citation_author=HW. Chung;citation_author=CY. Chen;citation_pages=113-17;citation_volume=79;citation_year=2010;citation_pmid=20137874" />
<meta name="citation_reference" content="citation_journal_title=Neurology;citation_author=G. McKhann;citation_author=D. Drachman;citation_author=M. Folstein;citation_pages=939-44;citation_volume=34;citation_year=1984;citation_doi=10.1212/WNL.34.7.939" />
<meta name="citation_reference" content="citation_journal_title=Journal of internal medicine;citation_journal_title=J Intern Med;citation_author=B. Winblad;citation_author=K. Palmer;citation_author=M. Kivipelto;citation_title=Mild cognitive impairment--beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment.;citation_pages=240-246;citation_volume=256;citation_year=2004;citation_issue=3;citation_pmid=15324367;citation_doi=10.1111/j.1365-2796.2004.01380.x" />
<meta name="citation_reference" content="citation_journal_title=Neurobiol Aging;citation_author=O. Carmichael;citation_author=D. Mungas;citation_author=L. Beckett;citation_pages=83-95;citation_volume=33;citation_year=2010;citation_pmid=20359776" />
<meta name="citation_reference" content="citation_journal_title=Magnetic resonance in medicine :  official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine;citation_journal_title=Magn Reson Med;citation_author=JC. Haselgrove;citation_author=JR. Moore;citation_title=Correction for distortion of echo-planar images used to calculate the apparent diffusion coefficient.;citation_pages=960-964;citation_volume=36;citation_year=1996;citation_issue=6;citation_pmid=8946363" />
<meta name="citation_reference" content="citation_journal_title=Stroke;citation_author=C. DeCarli;citation_author=E. Fletcher;citation_author=V. Ramey;citation_title=Anatomical mapping of white matter hyperintensities (WMH): exploring the relationships between periventricular WMH, deep WMH, and total WMH burden;citation_volume=36;citation_year=2005;citation_pmid=15576652;citation_doi=10.1161/01.STR.0000150668.58689.f2" />
<meta name="citation_reference" content="citation_journal_title=Journal of computer assisted tomography;citation_journal_title=J Comput Assist Tomogr;citation_author=P. Kochunov;citation_author=JL. Lancaster;citation_author=P. Thompson;citation_title=Regional spatial normalization: toward an optimal target.;citation_pages=805-816;citation_volume=25;citation_year=2001;citation_issue=5;citation_pmid=11584245;citation_doi=10.1097/00004728-200109000-00023" />
<meta name="citation_reference" content="citation_journal_title=Journal of computer assisted tomography;citation_journal_title=J Comput Assist Tomogr;citation_author=JC. Rajapakse;citation_author=C. DeCarli;citation_author=A. McLaughlin;citation_title=Cerebral magnetic resonance image segmentation using data fusion.;citation_pages=206-218;citation_volume=20;citation_year=1996;citation_issue=2;citation_pmid=8606224;citation_doi=10.1097/00004728-199603000-00007" />
<meta name="citation_reference" content="citation_journal_title=Stroke;citation_author=AA. Gouw;citation_author=WM. van der Flier;citation_author=F. Fazekas;citation_title=Progression of white matter hyperintensities and incidence of new lacunes over a 3-year period: the Leukoaraiosis and Disability Study;citation_volume=39;citation_year=2008;citation_pmid=18323505;citation_doi=10.1161/STROKEAHA.107.498535" />
<meta name="citation_reference" content="citation_journal_title=Stroke;citation_author=A. Nitkunan;citation_author=TR. Barrick;citation_author=RA. Charlton;citation_title=Multimodal MRI in cerebral small vessel disease: its relationship with cognition and sensitivity to change over time;citation_volume=39;citation_year=2008;citation_pmid=18436880;citation_doi=10.1161/STROKEAHA.107.507475" />
<meta name="citation_reference" content="citation_journal_title=Acta Radiol Suppl;citation_title=Magnetic resonance imaging in dementia: a study of brain white matter changes;citation_author=L. Bronge;citation_pages=1-32;citation_year=2002" />
<meta name="citation_reference" content="citation_journal_title=Journal of Neuropsychiatry and Clinical Neurosciences;citation_journal_title=J Neuropsychiatry Clin Neurosci;citation_author=P. Sachdev;citation_author=W. Wen;citation_author=R. Shnier;citation_title=Cerebral Blood Volume in T2-Weighted White Matter Hyperintensities Using Exogenous Contrast Based Perfusion MRI;citation_pages=83-92;citation_volume=16;citation_year=2004;citation_issue=1;citation_issn=0895-0172;citation_pmid=14990763" />
<meta name="citation_reference" content="citation_journal_title=MRI: The Basics;citation_author=RH. Hashemi;citation_author=WG. Bradley;citation_author=CJ. Lisanti;citation_year=2010" />
<meta name="citation_reference" content="citation_journal_title=Biological psychiatry;citation_journal_title=Biol Psychiatry;citation_author=K. Kim;citation_author=J. Macfall;citation_author=M. Payne;citation_title=Classification of white matter lesions on magnetic resonance imaging in elderly persons.;citation_pages=273-280;citation_volume=64;citation_year=2008;citation_issue=4;citation_pmid=18471801;citation_doi=10.1016/j.biopsych.2008.03.024" />
<meta name="citation_reference" content="citation_journal_title=Circulation;citation_author=O. Godin;citation_author=C. Tzourio;citation_author=P. Maillard;citation_title=Antihypertensive treatment and change in blood pressure are associated with the progression of white matter lesion volumes: the Three-City (3C)-Dijon Magnetic Resonance Imaging Study;citation_volume=123;citation_year=2011;citation_pmid=21220733;citation_doi=10.1161/CIRCULATIONAHA.110.961052" />
<meta name="citation_reference" content="citation_journal_title=Journal of neural transmission;citation_journal_title=J Neural Transm;citation_author=R. Schmidt;citation_author=A. Grazer;citation_author=C. Enzinger;citation_title=MRI-detected white matter lesions: do they really matter?;citation_pages=673-681;citation_volume=118;citation_year=2011;citation_issue=5;citation_pmid=21340713;citation_doi=10.1007/s00702-011-0594-9" />
<meta name="citation_reference" content="citation_journal_title=Stroke;citation_author=H. Xu;citation_author=B. Stamova;citation_author=G. Jickling;citation_title=Distinctive RNA expression profiles in blood associated with white matter hyperintensities in brain;citation_volume=41;citation_year=2010;citation_pmid=20966416;citation_doi=10.1161/STROKEAHA.110.591875" />
<meta name="citation_reference" content="citation_journal_title=Archives of Neurology;citation_journal_title=Arch Neurol;citation_author=NT. Aggarwal;citation_author=RS. Wilson;citation_author=JL. Bienias;citation_title=The Association of Magnetic Resonance Imaging Measures With Cognitive Function in a Biracial Population Sample;citation_pages=475-482;citation_volume=67;citation_year=2010;citation_issue=4;citation_issn=0003-9942;citation_pmid=20385915;citation_doi=10.1001/archneurol.2010.42" />
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<meta name="twitter:title" content="FLAIR and Diffusion MRI Signals Are Independent Predictors of White Matter Hyperintensities" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: WMH, associated with cognitive decline and cardiovascular risk factors, may represent only the extreme end of a more widespread continuous WM injury process that progresses during aging and is poorly understood. We investigated the ability of FLAIR and DTI to characterize the longitudinal course of WMH development.

MATERIALS AND METHODS: One hundred nineteen participants (mean age, 74.5 ± 7.4), including cognitively healthy elders and subjects diagnosed with Alzheimer disease and mild cognitive impairment, received a comprehensive clinical evaluation and brain MR imaging, including FLAIR and DTI on 2 dates. The risk for each baseline normal-appearing WM voxel to convert into WMH was modeled as a function of baseline FA (model M1) and both baseline FA and standardized FLAIR (M2). Sensitivity, specificity, accuracy, and AUC for predicting conversion to WMH were compared between models.

RESULTS: Independent of clinical diagnosis, lower baseline FA ( P &lt; .001, both models) and higher baseline FLAIR intensity ( P &lt; .001, M2) were independently associated with increased risk for conversion from normal WM to WMH. M1 exhibited higher sensitivity but lower specificity, accuracy, and AUC compared with M2.

CONCLUSIONS: These findings provide further evidence that WMH result from a continuous process of WM degeneration with time. Stepwise decreases in WM integrity as measured by both DTI and FLAIR were independently associated with stepwise increases in WMH risk, emphasizing that these modalities may provide complementary information for understanding the time course of aging-associated WM degeneration.

AD
:   Alzheimer disease
AUC
:   area under the receiver operating characteristic analysis curve
CN
:   cognitively healthy
FA
:   fractional anisotropy
M1
:   first logistic regression model
M2
:   second logistic regression model
MCI
:   mild cognitive impairment
MDT
:   minimal deformation template
nFA
:   baseline normalized FA
nFL
:   baseline normalized FLAIR
OR
:   odds ratio
WMH
:   white matter hyperintensities" />
<meta name="og-title" property="og:title" content="FLAIR and Diffusion MRI Signals Are Independent Predictors of White Matter Hyperintensities" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/34/1/54" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: WMH, associated with cognitive decline and cardiovascular risk factors, may represent only the extreme end of a more widespread continuous WM injury process that progresses during aging and is poorly understood. We investigated the ability of FLAIR and DTI to characterize the longitudinal course of WMH development.

MATERIALS AND METHODS: One hundred nineteen participants (mean age, 74.5 ± 7.4), including cognitively healthy elders and subjects diagnosed with Alzheimer disease and mild cognitive impairment, received a comprehensive clinical evaluation and brain MR imaging, including FLAIR and DTI on 2 dates. The risk for each baseline normal-appearing WM voxel to convert into WMH was modeled as a function of baseline FA (model M1) and both baseline FA and standardized FLAIR (M2). Sensitivity, specificity, accuracy, and AUC for predicting conversion to WMH were compared between models.

RESULTS: Independent of clinical diagnosis, lower baseline FA ( P &lt; .001, both models) and higher baseline FLAIR intensity ( P &lt; .001, M2) were independently associated with increased risk for conversion from normal WM to WMH. M1 exhibited higher sensitivity but lower specificity, accuracy, and AUC compared with M2.

CONCLUSIONS: These findings provide further evidence that WMH result from a continuous process of WM degeneration with time. Stepwise decreases in WM integrity as measured by both DTI and FLAIR were independently associated with stepwise increases in WMH risk, emphasizing that these modalities may provide complementary information for understanding the time course of aging-associated WM degeneration.

AD
:   Alzheimer disease
AUC
:   area under the receiver operating characteristic analysis curve
CN
:   cognitively healthy
FA
:   fractional anisotropy
M1
:   first logistic regression model
M2
:   second logistic regression model
MCI
:   mild cognitive impairment
MDT
:   minimal deformation template
nFA
:   baseline normalized FA
nFL
:   baseline normalized FLAIR
OR
:   odds ratio
WMH
:   white matter hyperintensities" />
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node12422--5" data-node-nid="12422" id="top-node-12422--62052407325" data-pisa="ajnr;34/1/54" data-pisa-master="ajnr;ajnr.A3146" data-apath="/ajnr/34/1/54.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
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      <h1 class="highwire-cite-title" id="page-title">FLAIR and Diffusion MRI Signals Are Independent Predictors of White Matter Hyperintensities</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">P. Maillard</span>, <span class="highwire-citation-author" data-delta="1">O. Carmichael</span>, <span class="highwire-citation-author" data-delta="2">D. Harvey</span>, <span class="highwire-citation-author" data-delta="3">E. Fletcher</span>, <span class="highwire-citation-author" data-delta="4">B. Reed</span>, <span class="highwire-citation-author" data-delta="5">D. Mungas</span> and <span class="highwire-citation-author" data-delta="6">C. DeCarli</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">January 2013,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">34 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(1) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">54-61; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A3146 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-12422--62052407325" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">P. Maillard </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Imaging of Dementia and Aging Laboratory (P.M., O.C., E.F., B.R., D.M., C.D.)</div><div class='author-affiliation'><span class='nlm-sup'>b</span>Department of Neurology and Center for Neuroscience (P.M., O.C., E.F., B.R., D.M., C.D.), University of California, Davis, Davis, California</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=P.%2BMaillard%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Maillard%20P&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AP.%2BMaillard%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">O. Carmichael </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Imaging of Dementia and Aging Laboratory (P.M., O.C., E.F., B.R., D.M., C.D.)</div><div class='author-affiliation'><span class='nlm-sup'>b</span>Department of Neurology and Center for Neuroscience (P.M., O.C., E.F., B.R., D.M., C.D.), University of California, Davis, Davis, California</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=O.%2BCarmichael%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Carmichael%20O&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AO.%2BCarmichael%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">D. Harvey </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Division of Biostatistics (D.H., B.R., D.M., C.D.), Department of Public Health Sciences, School of Medicine, University of California, Davis, Davis, California.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=D.%2BHarvey%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Harvey%20D&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AD.%2BHarvey%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">E. Fletcher </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Imaging of Dementia and Aging Laboratory (P.M., O.C., E.F., B.R., D.M., C.D.)</div><div class='author-affiliation'><span class='nlm-sup'>b</span>Department of Neurology and Center for Neuroscience (P.M., O.C., E.F., B.R., D.M., C.D.), University of California, Davis, Davis, California</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=E.%2BFletcher%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Fletcher%20E&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AE.%2BFletcher%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">B. Reed </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Imaging of Dementia and Aging Laboratory (P.M., O.C., E.F., B.R., D.M., C.D.)</div><div class='author-affiliation'><span class='nlm-sup'>b</span>Department of Neurology and Center for Neuroscience (P.M., O.C., E.F., B.R., D.M., C.D.), University of California, Davis, Davis, California</div><div class='author-affiliation'><span class='nlm-sup'>c</span>Division of Biostatistics (D.H., B.R., D.M., C.D.), Department of Public Health Sciences, School of Medicine, University of California, Davis, Davis, California.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=B.%2BReed%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Reed%20B&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AB.%2BReed%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-5"><div class="author-tooltip-name">D. Mungas </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Imaging of Dementia and Aging Laboratory (P.M., O.C., E.F., B.R., D.M., C.D.)</div><div class='author-affiliation'><span class='nlm-sup'>b</span>Department of Neurology and Center for Neuroscience (P.M., O.C., E.F., B.R., D.M., C.D.), University of California, Davis, Davis, California</div><div class='author-affiliation'><span class='nlm-sup'>c</span>Division of Biostatistics (D.H., B.R., D.M., C.D.), Department of Public Health Sciences, School of Medicine, University of California, Davis, Davis, California.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=D.%2BMungas%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Mungas%20D&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AD.%2BMungas%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-6"><div class="author-tooltip-name">C. DeCarli </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Imaging of Dementia and Aging Laboratory (P.M., O.C., E.F., B.R., D.M., C.D.)</div><div class='author-affiliation'><span class='nlm-sup'>b</span>Department of Neurology and Center for Neuroscience (P.M., O.C., E.F., B.R., D.M., C.D.), University of California, Davis, Davis, California</div><div class='author-affiliation'><span class='nlm-sup'>c</span>Division of Biostatistics (D.H., B.R., D.M., C.D.), Department of Public Health Sciences, School of Medicine, University of California, Davis, Davis, California.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=C.%2BDeCarli%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=DeCarli%20C&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AC.%2BDeCarli%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div></div></div>  </div>

  
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<p id="p-2"><strong>BACKGROUND AND PURPOSE:</strong> WMH, associated with cognitive decline and cardiovascular risk factors, may represent only the extreme end of a more widespread continuous WM injury process that progresses during aging and is poorly understood. We investigated the ability of FLAIR and DTI to characterize the longitudinal course of WMH development.</p>
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<p id="p-3"><strong>MATERIALS AND METHODS:</strong> One hundred nineteen participants (mean age, 74.5 ± 7.4), including cognitively healthy elders and subjects diagnosed with Alzheimer disease and mild cognitive impairment, received a comprehensive clinical evaluation and brain MR imaging, including FLAIR and DTI on 2 dates. The risk for each baseline normal-appearing WM voxel to convert into WMH was modeled as a function of baseline FA (model M1) and both baseline FA and standardized FLAIR (M2). Sensitivity, specificity, accuracy, and AUC for predicting conversion to WMH were compared between models.</p>
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<p id="p-4"><strong>RESULTS:</strong> Independent of clinical diagnosis, lower baseline FA (<em>P</em> &lt; .001, both models) and higher baseline FLAIR intensity (<em>P</em> &lt; .001, M2) were independently associated with increased risk for conversion from normal WM to WMH. M1 exhibited higher sensitivity but lower specificity, accuracy, and AUC compared with M2.</p>
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<p id="p-5"><strong>CONCLUSIONS:</strong> These findings provide further evidence that WMH result from a continuous process of WM degeneration with time. Stepwise decreases in WM integrity as measured by both DTI and FLAIR were independently associated with stepwise increases in WMH risk, emphasizing that these modalities may provide complementary information for understanding the time course of aging-associated WM degeneration.</p>
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</div><div class="section glossary" id="glossary-1">
<h2>ABBREVIATIONS:</h2>
<dl id="def-list-1"><dt id="def-item-1">AD<span class="def-item-dt-sep"></span></dt><dd>Alzheimer disease<span class="def-item-dd-sep"></span></dd><dt id="def-item-2">AUC<span class="def-item-dt-sep"></span></dt><dd>area under the receiver operating characteristic analysis curve<span class="def-item-dd-sep"></span></dd><dt id="def-item-3">CN<span class="def-item-dt-sep"></span></dt><dd>cognitively healthy<span class="def-item-dd-sep"></span></dd><dt id="def-item-4">FA<span class="def-item-dt-sep"></span></dt><dd>fractional anisotropy<span class="def-item-dd-sep"></span></dd><dt id="def-item-5">M1<span class="def-item-dt-sep"></span></dt><dd>first logistic regression model<span class="def-item-dd-sep"></span></dd><dt id="def-item-6">M2<span class="def-item-dt-sep"></span></dt><dd>second logistic regression model<span class="def-item-dd-sep"></span></dd><dt id="def-item-7">MCI<span class="def-item-dt-sep"></span></dt><dd>mild cognitive impairment<span class="def-item-dd-sep"></span></dd><dt id="def-item-8">MDT<span class="def-item-dt-sep"></span></dt><dd>minimal deformation template<span class="def-item-dd-sep"></span></dd><dt id="def-item-9">nFA<span class="def-item-dt-sep"></span></dt><dd>baseline normalized FA<span class="def-item-dd-sep"></span></dd><dt id="def-item-10">nFL<span class="def-item-dt-sep"></span></dt><dd>baseline normalized FLAIR<span class="def-item-dd-sep"></span></dd><dt id="def-item-11">OR<span class="def-item-dt-sep"></span></dt><dd>odds ratio<span class="def-item-dd-sep"></span></dd><dt id="def-item-12">WMH<span class="def-item-dt-sep"></span></dt><dd>white matter hyperintensities</dd></dl>
</div><ul class="copyright-statement"><li class="fn" id="copyright-statement-1">© 2013 by American Journal of Neuroradiology</li></ul><div class="license" id="license-1"><p id="p-1">Indicates open access to non-subscribers at <a href="http://www.ajnr.org">www.ajnr.org</a></p></div><span class="highwire-journal-article-marker-end"></span></div><span class="related-urls"></span></div><a href="http://ajnr-stage2.stage.highwire.org/content/34/1/54.full" class="hw-link hw-link-article-full-text" data-icon-position="" data-hide-link-title="0">View Full Text</a></div>  </div>

  
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 34</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 1 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Jan 2013 </div></div>
      
      
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      <div class="highwire-cite-title">FLAIR and Diffusion MRI Signals Are Independent Predictors of White Matter Hyperintensities</div>  
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    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-oa-ind highwire-cite-metadata"><i class="highwire-oa-indicator"></i> </span><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Jan 2013, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">34 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(1) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">54-61; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A3146 </span></div>
  
  
  
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