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<meta name="DC.Title" content="Brain β-Amyloid and Atrophy in Individuals at Increased Risk of Cognitive Decline" />
<meta name="DC.Identifier" content="10.3174/ajnr.A5891" />
<meta name="DC.Date" content="2019-01-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
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<meta name="DC.AccessRights" content="open-access" />
<meta name="DC.Description" content="BACKGROUND AND PURPOSE: The relationship between brain β-amyloid and regional atrophy is still incompletely understood in elderly individuals at risk of dementia. Here, we studied the associations between brain β-amyloid load and regional GM and WM volumes in older adults who were clinically evaluated as being at increased risk of cognitive decline based on cardiovascular risk factors.

MATERIALS AND METHODS: Forty subjects (63–81 years of age) were recruited as part of a larger study, the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability. Neuroimaging consisted of PET using 11C Pittsburgh compound-B and T1-weighted 3D MR imaging for the measurement of brain β-amyloid and GM and WM volumes, respectively. All subjects underwent clinical, genetic, and neuropsychological evaluations for the assessment of cognitive function and the identification of cardiovascular risk factors.

RESULTS: Sixteen subjects were visually evaluated as showing cortical β-amyloid (positive for β-amyloid). In the voxel-by-voxel analyses, no significant differences were found in GM and WM volumes between the samples positive and negative for β-amyloid. However, in the sample positive for β-amyloid, increases in 11C Pittsburgh compound-B uptake were associated with reductions in GM volume in the left prefrontal ( P = .02) and right temporal lobes ( P = .04).

CONCLUSIONS: Our results show a significant association between increases in brain β-amyloid and reductions in regional GM volume in individuals at increased risk of cognitive decline. This evidence is consistent with a model in which increases in β-amyloid incite neurodegeneration in memory systems before cognitive impairment manifests.

AD
:   Alzheimer disease
APOE 
:   Apolipoprotein E 
Aβ
:   β-amyloid
PIB
:   Pittsburgh compound-B
PIB−
:   PIB negative
PIB+
:   PIB positive" />
<meta name="DC.Contributor" content="I.K. Martikainen" />
<meta name="DC.Contributor" content="N. Kemppainen" />
<meta name="DC.Contributor" content="J. Johansson" />
<meta name="DC.Contributor" content="J. Teuho" />
<meta name="DC.Contributor" content="S. Helin" />
<meta name="DC.Contributor" content="Y. Liu" />
<meta name="DC.Contributor" content="S. Helisalmi" />
<meta name="DC.Contributor" content="H. Soininen" />
<meta name="DC.Contributor" content="R. Parkkola" />
<meta name="DC.Contributor" content="T. Ngandu" />
<meta name="DC.Contributor" content="M. Kivipelto" />
<meta name="DC.Contributor" content="J.O. Rinne" />
<meta name="article:published_time" content="2019-01-01" />
<meta name="article:section" content="Adult Brain" />
<meta name="citation_title" content="Brain β-Amyloid and Atrophy in Individuals at Increased Risk of Cognitive Decline" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;The relationship between brain β-amyloid and regional atrophy is still incompletely understood in elderly individuals at risk of dementia. Here, we studied the associations between brain β-amyloid load and regional GM and WM volumes in older adults who were clinically evaluated as being at increased risk of cognitive decline based on cardiovascular risk factors.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;Forty subjects (63–81 years of age) were recruited as part of a larger study, the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability. Neuroimaging consisted of PET using &lt;sup&gt;11&lt;/sup&gt;C Pittsburgh compound-B and T1-weighted 3D MR imaging for the measurement of brain β-amyloid and GM and WM volumes, respectively. All subjects underwent clinical, genetic, and neuropsychological evaluations for the assessment of cognitive function and the identification of cardiovascular risk factors.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;Sixteen subjects were visually evaluated as showing cortical β-amyloid (positive for β-amyloid). In the voxel-by-voxel analyses, no significant differences were found in GM and WM volumes between the samples positive and negative for β-amyloid. However, in the sample positive for β-amyloid, increases in &lt;sup&gt;11&lt;/sup&gt;C Pittsburgh compound-B uptake were associated with reductions in GM volume in the left prefrontal (&lt;i&gt;P&lt;/i&gt; = .02) and right temporal lobes (&lt;i&gt;P&lt;/i&gt; = .04).&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;Our results show a significant association between increases in brain β-amyloid and reductions in regional GM volume in individuals at increased risk of cognitive decline. This evidence is consistent with a model in which increases in β-amyloid incite neurodegeneration in memory systems before cognitive impairment manifests.&lt;/p&gt;" />
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<meta name="citation_author" content="I.K. Martikainen" />
<meta name="citation_author_institution" content="aFrom the Department of Radiology (I.K.M.), Medical Imaging Center, Tampere University Hospital, Tampere, Finland" />
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<meta name="citation_author" content="N. Kemppainen" />
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<meta name="citation_author_institution" content="fDepartment of Radiology (R.P.), University of Turku and Turku University Hospital, Turku, Finland" />
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<meta name="twitter:title" content="Brain β-Amyloid and Atrophy in Individuals at Increased Risk of Cognitive Decline" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: The relationship between brain β-amyloid and regional atrophy is still incompletely understood in elderly individuals at risk of dementia. Here, we studied the associations between brain β-amyloid load and regional GM and WM volumes in older adults who were clinically evaluated as being at increased risk of cognitive decline based on cardiovascular risk factors.

MATERIALS AND METHODS: Forty subjects (63–81 years of age) were recruited as part of a larger study, the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability. Neuroimaging consisted of PET using 11C Pittsburgh compound-B and T1-weighted 3D MR imaging for the measurement of brain β-amyloid and GM and WM volumes, respectively. All subjects underwent clinical, genetic, and neuropsychological evaluations for the assessment of cognitive function and the identification of cardiovascular risk factors.

RESULTS: Sixteen subjects were visually evaluated as showing cortical β-amyloid (positive for β-amyloid). In the voxel-by-voxel analyses, no significant differences were found in GM and WM volumes between the samples positive and negative for β-amyloid. However, in the sample positive for β-amyloid, increases in 11C Pittsburgh compound-B uptake were associated with reductions in GM volume in the left prefrontal ( P = .02) and right temporal lobes ( P = .04).

CONCLUSIONS: Our results show a significant association between increases in brain β-amyloid and reductions in regional GM volume in individuals at increased risk of cognitive decline. This evidence is consistent with a model in which increases in β-amyloid incite neurodegeneration in memory systems before cognitive impairment manifests.

AD
:   Alzheimer disease
APOE 
:   Apolipoprotein E 
Aβ
:   β-amyloid
PIB
:   Pittsburgh compound-B
PIB−
:   PIB negative
PIB+
:   PIB positive" />
<meta name="og-title" property="og:title" content="Brain β-Amyloid and Atrophy in Individuals at Increased Risk of Cognitive Decline" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/40/1/80" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: The relationship between brain β-amyloid and regional atrophy is still incompletely understood in elderly individuals at risk of dementia. Here, we studied the associations between brain β-amyloid load and regional GM and WM volumes in older adults who were clinically evaluated as being at increased risk of cognitive decline based on cardiovascular risk factors.

MATERIALS AND METHODS: Forty subjects (63–81 years of age) were recruited as part of a larger study, the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability. Neuroimaging consisted of PET using 11C Pittsburgh compound-B and T1-weighted 3D MR imaging for the measurement of brain β-amyloid and GM and WM volumes, respectively. All subjects underwent clinical, genetic, and neuropsychological evaluations for the assessment of cognitive function and the identification of cardiovascular risk factors.

RESULTS: Sixteen subjects were visually evaluated as showing cortical β-amyloid (positive for β-amyloid). In the voxel-by-voxel analyses, no significant differences were found in GM and WM volumes between the samples positive and negative for β-amyloid. However, in the sample positive for β-amyloid, increases in 11C Pittsburgh compound-B uptake were associated with reductions in GM volume in the left prefrontal ( P = .02) and right temporal lobes ( P = .04).

CONCLUSIONS: Our results show a significant association between increases in brain β-amyloid and reductions in regional GM volume in individuals at increased risk of cognitive decline. This evidence is consistent with a model in which increases in β-amyloid incite neurodegeneration in memory systems before cognitive impairment manifests.

AD
:   Alzheimer disease
APOE 
:   Apolipoprotein E 
Aβ
:   β-amyloid
PIB
:   Pittsburgh compound-B
PIB−
:   PIB negative
PIB+
:   PIB positive" />
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node65269--5" data-node-nid="65269" id="top-node-65269--6378736056" data-pisa="ajnr;40/1/80" data-pisa-master="ajnr;ajnr.A5891" data-apath="/ajnr/40/1/80.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">Adult Brain</span></span></div>
  
      <div class="highwire-cite-access"><span class="highwire-citation-access"><i class="highwire-access-icon highwire-access-icon-open-access open-access hw-icon-open-access" title="Open Access" aria-hidden="true"></i><span  class="element-invisible highwire-access-icon highwire-access-icon-open-access" style="">Open Access</span></span></div>
  
      <h1 class="highwire-cite-title" id="page-title">Brain β-Amyloid and Atrophy in Individuals at Increased Risk of Cognitive Decline</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">I.K. Martikainen</span>, <span class="highwire-citation-author" data-delta="1">N. Kemppainen</span>, <span class="highwire-citation-author" data-delta="2">J. Johansson</span>, <span class="highwire-citation-author" data-delta="3">J. Teuho</span>, <span class="highwire-citation-author" data-delta="4">S. Helin</span>, <span class="highwire-citation-author" data-delta="5">Y. Liu</span>, <span class="highwire-citation-author" data-delta="6">S. Helisalmi</span>, <span class="highwire-citation-author" data-delta="7">H. Soininen</span>, <span class="highwire-citation-author" data-delta="8">R. Parkkola</span>, <span class="highwire-citation-author" data-delta="9">T. Ngandu</span>, <span class="highwire-citation-author" data-delta="10">M. Kivipelto</span> and <span class="highwire-citation-author" data-delta="11">J.O. Rinne</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">January 2019,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">40 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(1) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">80-85; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A5891 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-65269--6378736056" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">I.K. Martikainen </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology (I.K.M.), Medical Imaging Center, Tampere University Hospital, Tampere, Finland</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=I.K.%2BMartikainen%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Martikainen%20I&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AI.K.%2BMartikainen%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-6025-6994" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for I.K. Martikainen</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">N. Kemppainen </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Division of Clinical Neurosciences (N.K., J.O.R.), Turku University Hospital, Turku, Finland</div><div class='author-affiliation'><span class='nlm-sup'>c</span>Turku PET Centre (N.K., J.J., J.T., S. Helin, J.O.R.), University of Turku, Turku, Finland</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=N.%2BKemppainen%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Kemppainen%20N&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AN.%2BKemppainen%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-8988-5858" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for N. Kemppainen</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">J. Johansson </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Turku PET Centre (N.K., J.J., J.T., S. Helin, J.O.R.), University of Turku, Turku, Finland</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.%2BJohansson%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Johansson%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AJ.%2BJohansson%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-4501-4735" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for J. Johansson</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">J. Teuho </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Turku PET Centre (N.K., J.J., J.T., S. Helin, J.O.R.), University of Turku, Turku, Finland</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.%2BTeuho%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Teuho%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AJ.%2BTeuho%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-9401-0725" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for J. Teuho</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">S. Helin </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Turku PET Centre (N.K., J.J., J.T., S. Helin, J.O.R.), University of Turku, Turku, Finland</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=S.%2BHelin%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Helin%20S&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AS.%2BHelin%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-9405-7301" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for S. Helin</a></li></ul></div><div class="author-tooltip-5"><div class="author-tooltip-name">Y. Liu </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>d</span>Department of Neurology (Y.L., S. Helisalmi, H.S., M.K.), University of Eastern Finland, Kuopio, Finland</div><div class='author-affiliation'><span class='nlm-sup'>e</span>Neurocenter (Y.L., H.S., M.K.), Neurology, Kuopio University Hospital, Kuopio, Finland</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Y.%2BLiu%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Liu%20Y&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AY.%2BLiu%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-2386-3370" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for Y. Liu</a></li></ul></div><div class="author-tooltip-6"><div class="author-tooltip-name">S. Helisalmi </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>d</span>Department of Neurology (Y.L., S. Helisalmi, H.S., M.K.), University of Eastern Finland, Kuopio, Finland</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=S.%2BHelisalmi%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Helisalmi%20S&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AS.%2BHelisalmi%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-3982-2397" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for S. Helisalmi</a></li></ul></div><div class="author-tooltip-7"><div class="author-tooltip-name">H. Soininen </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>d</span>Department of Neurology (Y.L., S. Helisalmi, H.S., M.K.), University of Eastern Finland, Kuopio, Finland</div><div class='author-affiliation'><span class='nlm-sup'>e</span>Neurocenter (Y.L., H.S., M.K.), Neurology, Kuopio University Hospital, Kuopio, Finland</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=H.%2BSoininen%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Soininen%20H&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AH.%2BSoininen%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-2785-9937" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for H. Soininen</a></li></ul></div><div class="author-tooltip-8"><div class="author-tooltip-name">R. Parkkola </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>f</span>Department of Radiology (R.P.), University of Turku and Turku University Hospital, Turku, Finland</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=R.%2BParkkola%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Parkkola%20R&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AR.%2BParkkola%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-8046-315X" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for R. Parkkola</a></li></ul></div><div class="author-tooltip-9"><div class="author-tooltip-name">T. Ngandu </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>g</span>Department of Public Health Solutions (T.N., M.K.), Public Health Promotion Unit, National Institute for Health and Welfare, Helsinki, Finland</div><div class='author-affiliation'><span class='nlm-sup'>h</span>Division of Clinical Geriatrics (T.N., M.K.), Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=T.%2BNgandu%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Ngandu%20T&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AT.%2BNgandu%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-3698-2021" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for T. Ngandu</a></li></ul></div><div class="author-tooltip-10"><div class="author-tooltip-name">M. Kivipelto </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>d</span>Department of Neurology (Y.L., S. Helisalmi, H.S., M.K.), University of Eastern Finland, Kuopio, Finland</div><div class='author-affiliation'><span class='nlm-sup'>e</span>Neurocenter (Y.L., H.S., M.K.), Neurology, Kuopio University Hospital, Kuopio, Finland</div><div class='author-affiliation'><span class='nlm-sup'>g</span>Department of Public Health Solutions (T.N., M.K.), Public Health Promotion Unit, National Institute for Health and Welfare, Helsinki, Finland</div><div class='author-affiliation'><span class='nlm-sup'>h</span>Division of Clinical Geriatrics (T.N., M.K.), Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.%2BKivipelto%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Kivipelto%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AM.%2BKivipelto%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-0992-3875" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for M. 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      <div class="highwire-cite-title">Brain β-Amyloid and Atrophy in Individuals at Increased Risk of Cognitive Decline</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">I.K.</span> <span class="nlm-surname">Martikainen</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">N.</span> <span class="nlm-surname">Kemppainen</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">J.</span> <span class="nlm-surname">Johansson</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">J.</span> <span class="nlm-surname">Teuho</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">S.</span> <span class="nlm-surname">Helin</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Y.</span> <span class="nlm-surname">Liu</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">S.</span> <span class="nlm-surname">Helisalmi</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">H.</span> <span class="nlm-surname">Soininen</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">R.</span> <span class="nlm-surname">Parkkola</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">T.</span> <span class="nlm-surname">Ngandu</span></span>, <span class="highwire-citation-author" data-delta="10"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Kivipelto</span></span>, <span class="highwire-citation-author" data-delta="11"><span class="nlm-given-names">J.O.</span> <span class="nlm-surname">Rinne</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-oa-ind highwire-cite-metadata"><i class="highwire-oa-indicator"></i> </span><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Jan 2019, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">40 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(1) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">80-85; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A5891 </span></div>
  
  
  
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      <div class="highwire-cite-title">Brain β-Amyloid and Atrophy in Individuals at Increased Risk of Cognitive Decline</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">I.K.</span> <span class="nlm-surname">Martikainen</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">N.</span> <span class="nlm-surname">Kemppainen</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">J.</span> <span class="nlm-surname">Johansson</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">J.</span> <span class="nlm-surname">Teuho</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">S.</span> <span class="nlm-surname">Helin</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Y.</span> <span class="nlm-surname">Liu</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">S.</span> <span class="nlm-surname">Helisalmi</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">H.</span> <span class="nlm-surname">Soininen</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">R.</span> <span class="nlm-surname">Parkkola</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">T.</span> <span class="nlm-surname">Ngandu</span></span>, <span class="highwire-citation-author" data-delta="10"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Kivipelto</span></span>, <span class="highwire-citation-author" data-delta="11"><span class="nlm-given-names">J.O.</span> <span class="nlm-surname">Rinne</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-oa-ind highwire-cite-metadata"><i class="highwire-oa-indicator"></i> </span><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Jan 2019, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">40 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(1) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">80-85; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A5891 </span></div>
  
  
  
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