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<meta name="DC.Title" content="Thalamic Involvement and Its Impact on Clinical Disability in Patients with Multiple Sclerosis: A Diffusion Tensor Imaging Study at 3T" />
<meta name="DC.Identifier" content="10.3174/ajnr.A1564" />
<meta name="DC.Date" content="2009-08-01" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Several studies suggest that grey matter involvement may play a role in multiple sclerosis (MS) pathology. Diffusion tensor imaging (DTI) at 3T was used to investigate the presence of damage to the normal-appearing thalamus in MS and its relationship with disability.

MATERIALS AND METHODS: Twenty-four patients with relapsing-remitting (RR, n = 13, age = 41.7 ± 6.1, Expanded Disability Status Scale [EDSS] score = 2.2 ± 1.2) and secondary-progressive ( n = 11, age = 46.9 ± 9.6, EDSS = 5.9 ± 1.0) MS and 24 age- and sex-matched healthy volunteers were studied. Fractional anisotropy (FA) and mean diffusivity (MD) were measured in regions of interest of normal-appearing thalamus. We examined group differences in MD and FA and correlations between DTI-derived metrics and clinical or imaging measures of disease.

RESULTS: Patients with MS had higher thalamic FA ( P &lt; .0001) and MD ( P = .035) than volunteers. MD values correlated with the Paced Auditory Serial Addition Task ( r = −0.43, P = .034) and motor EDSS ( r = 0.47, P = .021) scores. In patients with RRMS, MD values correlated with global EDSS ( r = 0.75, P = .003) and motor EDSS ( r = 0.68, P = .010). Correlations were found between MD values and T1 and T2 lesion load ( r = 0.58, P &lt; .05) and brain parenchymal fraction ( r = −0.46, P &lt; .05).

CONCLUSIONS: DTI was able to detect abnormalities in normal-appearing thalamus of patients with MS. The strength of association between thalamic DTI measures and functional impairment was in the same range as those seen with standard MR imaging disease measures. The assessment of the integrity of the thalamus with DTI is a promising metric as a marker of disease for future studies." />
<meta name="DC.Contributor" content="F. Tovar-Moll" />
<meta name="DC.Contributor" content="I.E. Evangelou" />
<meta name="DC.Contributor" content="A.W. Chiu" />
<meta name="DC.Contributor" content="N.D. Richert" />
<meta name="DC.Contributor" content="J.L. Ostuni" />
<meta name="DC.Contributor" content="J.M. Ohayon" />
<meta name="DC.Contributor" content="S. Auh" />
<meta name="DC.Contributor" content="M. Ehrmantraut" />
<meta name="DC.Contributor" content="S.L. Talagala" />
<meta name="DC.Contributor" content="H.F. McFarland" />
<meta name="DC.Contributor" content="F. Bagnato" />
<meta name="article:published_time" content="2009-08-01" />
<meta name="article:section" content="BRAIN" />
<meta name="citation_title" content="Thalamic Involvement and Its Impact on Clinical Disability in Patients with Multiple Sclerosis: A Diffusion Tensor Imaging Study at 3T" />
<meta name="citation_abstract" lang="en" content="&lt;p&gt;&lt;b&gt;BACKGROUND AND PURPOSE:&lt;/b&gt; Several studies suggest that grey matter involvement may play a role in multiple sclerosis (MS) pathology. Diffusion tensor imaging (DTI) at 3T was used to investigate the presence of damage to the normal-appearing thalamus in MS and its relationship with disability.&lt;/p&gt;&lt;p&gt;&lt;b&gt;MATERIALS AND METHODS:&lt;/b&gt; Twenty-four patients with relapsing-remitting (RR, &lt;i&gt;n&lt;/i&gt; = 13, age = 41.7 ± 6.1, Expanded Disability Status Scale [EDSS] score = 2.2 ± 1.2) and secondary-progressive (&lt;i&gt;n&lt;/i&gt; = 11, age = 46.9 ± 9.6, EDSS = 5.9 ± 1.0) MS and 24 age- and sex-matched healthy volunteers were studied. Fractional anisotropy (FA) and mean diffusivity (MD) were measured in regions of interest of normal-appearing thalamus. We examined group differences in MD and FA and correlations between DTI-derived metrics and clinical or imaging measures of disease.&lt;/p&gt;&lt;p&gt;&lt;b&gt;RESULTS:&lt;/b&gt; Patients with MS had higher thalamic FA (&lt;i&gt;P&lt;/i&gt; &amp;lt; .0001) and MD (&lt;i&gt;P&lt;/i&gt; = .035) than volunteers. MD values correlated with the Paced Auditory Serial Addition Task (&lt;i&gt;r&lt;/i&gt; = −0.43, &lt;i&gt;P&lt;/i&gt; = .034) and motor EDSS (&lt;i&gt;r&lt;/i&gt; = 0.47, &lt;i&gt;P&lt;/i&gt; = .021) scores. In patients with RRMS, MD values correlated with global EDSS (&lt;i&gt;r&lt;/i&gt; = 0.75, &lt;i&gt;P&lt;/i&gt; = .003) and motor EDSS (&lt;i&gt;r&lt;/i&gt; = 0.68, &lt;i&gt;P&lt;/i&gt; = .010). Correlations were found between MD values and T1 and T2 lesion load (&lt;i&gt;r&lt;/i&gt; = 0.58, &lt;i&gt;P&lt;/i&gt; &amp;lt; .05) and brain parenchymal fraction (&lt;i&gt;r&lt;/i&gt; = −0.46, &lt;i&gt;P&lt;/i&gt; &amp;lt; .05).&lt;/p&gt;&lt;p&gt;&lt;b&gt;CONCLUSIONS:&lt;/b&gt; DTI was able to detect abnormalities in normal-appearing thalamus of patients with MS. The strength of association between thalamic DTI measures and functional impairment was in the same range as those seen with standard MR imaging disease measures. The assessment of the integrity of the thalamus with DTI is a promising metric as a marker of disease for future studies.&lt;/p&gt;" />
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<meta name="citation_firstpage" content="1380" />
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<meta name="citation_author" content="F. Tovar-Moll" />
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<meta name="twitter:title" content="Thalamic Involvement and Its Impact on Clinical Disability in Patients with Multiple Sclerosis: A Diffusion Tensor Imaging Study at 3T" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Several studies suggest that grey matter involvement may play a role in multiple sclerosis (MS) pathology. Diffusion tensor imaging (DTI) at 3T was used to investigate the presence of damage to the normal-appearing thalamus in MS and its relationship with disability.

MATERIALS AND METHODS: Twenty-four patients with relapsing-remitting (RR, n = 13, age = 41.7 ± 6.1, Expanded Disability Status Scale [EDSS] score = 2.2 ± 1.2) and secondary-progressive ( n = 11, age = 46.9 ± 9.6, EDSS = 5.9 ± 1.0) MS and 24 age- and sex-matched healthy volunteers were studied. Fractional anisotropy (FA) and mean diffusivity (MD) were measured in regions of interest of normal-appearing thalamus. We examined group differences in MD and FA and correlations between DTI-derived metrics and clinical or imaging measures of disease.

RESULTS: Patients with MS had higher thalamic FA ( P &lt; .0001) and MD ( P = .035) than volunteers. MD values correlated with the Paced Auditory Serial Addition Task ( r = −0.43, P = .034) and motor EDSS ( r = 0.47, P = .021) scores. In patients with RRMS, MD values correlated with global EDSS ( r = 0.75, P = .003) and motor EDSS ( r = 0.68, P = .010). Correlations were found between MD values and T1 and T2 lesion load ( r = 0.58, P &lt; .05) and brain parenchymal fraction ( r = −0.46, P &lt; .05).

CONCLUSIONS: DTI was able to detect abnormalities in normal-appearing thalamus of patients with MS. The strength of association between thalamic DTI measures and functional impairment was in the same range as those seen with standard MR imaging disease measures. The assessment of the integrity of the thalamus with DTI is a promising metric as a marker of disease for future studies." />
<meta name="og-title" property="og:title" content="Thalamic Involvement and Its Impact on Clinical Disability in Patients with Multiple Sclerosis: A Diffusion Tensor Imaging Study at 3T" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/30/7/1380" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Several studies suggest that grey matter involvement may play a role in multiple sclerosis (MS) pathology. Diffusion tensor imaging (DTI) at 3T was used to investigate the presence of damage to the normal-appearing thalamus in MS and its relationship with disability.

MATERIALS AND METHODS: Twenty-four patients with relapsing-remitting (RR, n = 13, age = 41.7 ± 6.1, Expanded Disability Status Scale [EDSS] score = 2.2 ± 1.2) and secondary-progressive ( n = 11, age = 46.9 ± 9.6, EDSS = 5.9 ± 1.0) MS and 24 age- and sex-matched healthy volunteers were studied. Fractional anisotropy (FA) and mean diffusivity (MD) were measured in regions of interest of normal-appearing thalamus. We examined group differences in MD and FA and correlations between DTI-derived metrics and clinical or imaging measures of disease.

RESULTS: Patients with MS had higher thalamic FA ( P &lt; .0001) and MD ( P = .035) than volunteers. MD values correlated with the Paced Auditory Serial Addition Task ( r = −0.43, P = .034) and motor EDSS ( r = 0.47, P = .021) scores. In patients with RRMS, MD values correlated with global EDSS ( r = 0.75, P = .003) and motor EDSS ( r = 0.68, P = .010). Correlations were found between MD values and T1 and T2 lesion load ( r = 0.58, P &lt; .05) and brain parenchymal fraction ( r = −0.46, P &lt; .05).

CONCLUSIONS: DTI was able to detect abnormalities in normal-appearing thalamus of patients with MS. The strength of association between thalamic DTI measures and functional impairment was in the same range as those seen with standard MR imaging disease measures. The assessment of the integrity of the thalamus with DTI is a promising metric as a marker of disease for future studies." />
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node1800--5" data-node-nid="1800" id="top-node-1800--6260507080" data-pisa="ajnr;30/7/1380" data-pisa-master="ajnr;ajnr.A1564" data-apath="/ajnr/30/7/1380.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
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      <h1 class="highwire-cite-title" id="page-title">Thalamic Involvement and Its Impact on Clinical Disability in Patients with Multiple Sclerosis: A Diffusion Tensor Imaging Study at 3T</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">F. Tovar-Moll</span>, <span class="highwire-citation-author" data-delta="1">I.E. Evangelou</span>, <span class="highwire-citation-author" data-delta="2">A.W. Chiu</span>, <span class="highwire-citation-author" data-delta="3">N.D. Richert</span>, <span class="highwire-citation-author" data-delta="4">J.L. Ostuni</span>, <span class="highwire-citation-author" data-delta="5">J.M. Ohayon</span>, <span class="highwire-citation-author" data-delta="6">S. Auh</span>, <span class="highwire-citation-author" data-delta="7">M. Ehrmantraut</span>, <span class="highwire-citation-author" data-delta="8">S.L. Talagala</span>, <span class="highwire-citation-author" data-delta="9">H.F. McFarland</span> and <span class="highwire-citation-author" data-delta="10">F. Bagnato</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">August 2009,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">30 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(7) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1380-1386; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A1564 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-1800--6260507080" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">F. Tovar-Moll </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=F.%2BTovar-Moll%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Tovar-Moll%20F&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AF.%2BTovar-Moll%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">I.E. 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    <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" data-highwire-cite-ref-tooltip-instance="highwire_reflinks_tooltip" class="content-block-markup" xmlns:xhtml="http://www.w3.org/1999/xhtml"><div class="article abstract-view"><span class="highwire-journal-article-marker-start"></span><div class="section abstract" id="abstract-1"><h2>Abstract</h2><p id="p-2"><strong>BACKGROUND AND PURPOSE:</strong> Several studies suggest that grey matter involvement may play a role in multiple sclerosis (MS) pathology. Diffusion tensor imaging (DTI) at 3T was used to investigate the presence of damage to the normal-appearing thalamus in MS and its relationship with disability.</p><p id="p-3"><strong>MATERIALS AND METHODS:</strong> Twenty-four patients with relapsing-remitting (RR, <em>n</em> = 13, age = 41.7 ± 6.1, Expanded Disability Status Scale [EDSS] score = 2.2 ± 1.2) and secondary-progressive (<em>n</em> = 11, age = 46.9 ± 9.6, EDSS = 5.9 ± 1.0) MS and 24 age- and sex-matched healthy volunteers were studied. Fractional anisotropy (FA) and mean diffusivity (MD) were measured in regions of interest of normal-appearing thalamus. We examined group differences in MD and FA and correlations between DTI-derived metrics and clinical or imaging measures of disease.</p><p id="p-4"><strong>RESULTS:</strong> Patients with MS had higher thalamic FA (<em>P</em> &lt; .0001) and MD (<em>P</em> = .035) than volunteers. MD values correlated with the Paced Auditory Serial Addition Task (<em>r</em> = −0.43, <em>P</em> = .034) and motor EDSS (<em>r</em> = 0.47, <em>P</em> = .021) scores. In patients with RRMS, MD values correlated with global EDSS (<em>r</em> = 0.75, <em>P</em> = .003) and motor EDSS (<em>r</em> = 0.68, <em>P</em> = .010). Correlations were found between MD values and T1 and T2 lesion load (<em>r</em> = 0.58, <em>P</em> &lt; .05) and brain parenchymal fraction (<em>r</em> = −0.46, <em>P</em> &lt; .05).</p><p id="p-5"><strong>CONCLUSIONS:</strong> DTI was able to detect abnormalities in normal-appearing thalamus of patients with MS. The strength of association between thalamic DTI measures and functional impairment was in the same range as those seen with standard MR imaging disease measures. The assessment of the integrity of the thalamus with DTI is a promising metric as a marker of disease for future studies.</p></div><ul class="copyright-statement"><li class="fn" id="copyright-statement-1">American Society of Neuroradiology</li></ul><div class="license" id="license-1"><p id="p-1"></p></div><span class="highwire-journal-article-marker-end"></span></div><span class="related-urls"></span></div><a href="http://ajnr-stage2.stage.highwire.org/content/30/7/1380.full" class="hw-link hw-link-article-full-text" data-icon-position="" data-hide-link-title="0">View Full Text</a></div>  </div>

  
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 30</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 7 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">August 2009 </div></div>
      
      
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