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<meta name="DC.Title" content="The Artisse Intrasaccular Device: A New Intrasaccular Flow Diverter for the Treatment of Cerebral Aneurysms" />
<meta name="DC.Identifier" content="10.3174/ajnr.A8478" />
<meta name="DC.Date" content="2024-12-20" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="© 2025 by American Journal of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: This animal study was designed to evaluate in vivo the acute and short-term safety and efficacy of the new Artisse intrasaccular device (ISD) for aneurysm occlusion and to gain knowledge about the behavior in the aneurysms.

MATERIALS AND METHODS: The device was implanted in 7 white New Zealand rabbits with bifurcation aneurysms. Immediate and 90-day angiographic follow-up as well as histologic and scanning electron microscope imaging were evaluated.

RESULTS: Immediate postinterventional angiograms showed excellent flow reduction in all aneurysms. Progressive improvements of occlusion rate could be observed in 5 of 7 aneurysms. One device migration was noted due to undersizing, resulting in corresponding worsening of occlusion rate. Three-month microscopic examinations demonstrated excellent biocompatibility. Notably, the Artisse ISD showed increased connective tissue formation within the aneurysm sac, which correlated with the angiographic results.

CONCLUSIONS: The new Artisse ISD adapted well to aneurysm morphology and created immediate contrast stasis and excellent neck coverage. While angiographic results showed only moderate adequate occlusion at 3 months, histologic data showed excellent biocompatibility and good connective tissue formation within the aneurysm sac in all aneurysms treated with the Artisse ISD. Sizing and correct positioning appear to be crucial for adequate occlusion.

DAPT
:   dual antiplatelet therapy
DFT
:   drawn-filled tubing
ID
:   inner diameter
IFD
:   intrasaccular flow diverter
ISD
:   intrasaccular device
mRRC
:   modified Raymond-Roy classification
NiTi
:   Nitinol
OKM
:   O’Kelly-Marotta scale
WEB
:   Woven Endobridge" />
<meta name="DC.Contributor" content="Constantin Hecker" />
<meta name="DC.Contributor" content="Clemens Hufnagl" />
<meta name="DC.Contributor" content="Andreas Oellerer" />
<meta name="DC.Contributor" content="Christoph J. Griessenauer" />
<meta name="DC.Contributor" content="Monika Killer-Oberpfalzer" />
<meta name="article:published_time" content="2025-12-19" />
<meta name="article:section" content="NEUROINTERVENTION" />
<meta name="citation_title" content="The Artisse Intrasaccular Device: A New Intrasaccular Flow Diverter for the Treatment of Cerebral Aneurysms" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;This animal study was designed to evaluate in vivo the acute and short-term safety and efficacy of the new Artisse intrasaccular device (ISD) for aneurysm occlusion and to gain knowledge about the behavior in the aneurysms.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;The device was implanted in 7 white New Zealand rabbits with bifurcation aneurysms. Immediate and 90-day angiographic follow-up as well as histologic and scanning electron microscope imaging were evaluated.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;Immediate postinterventional angiograms showed excellent flow reduction in all aneurysms. Progressive improvements of occlusion rate could be observed in 5 of 7 aneurysms. One device migration was noted due to undersizing, resulting in corresponding worsening of occlusion rate. Three-month microscopic examinations demonstrated excellent biocompatibility. Notably, the Artisse ISD showed increased connective tissue formation within the aneurysm sac, which correlated with the angiographic results.&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;The new Artisse ISD adapted well to aneurysm morphology and created immediate contrast stasis and excellent neck coverage. While angiographic results showed only moderate adequate occlusion at 3 months, histologic data showed excellent biocompatibility and good connective tissue formation within the aneurysm sac in all aneurysms treated with the Artisse ISD. Sizing and correct positioning appear to be crucial for adequate occlusion.&lt;/p&gt;" />
<meta name="citation_journal_title" content="American Journal of Neuroradiology" />
<meta name="citation_publisher" content="American Journal of Neuroradiology" />
<meta name="citation_publication_date" content="2025/12/19" />
<meta name="citation_mjid" content="ajnr;ajnr.A8478v1" />
<meta name="citation_id" content="ajnr.A8478v1" />
<meta name="citation_public_url" content="http://ajnr-stage2.stage.highwire.org/content/early/2024/12/20/ajnr.A8478" />
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<meta name="citation_issn" content="0195-6108" />
<meta name="citation_issn" content="1936-959X" />
<meta name="citation_doi" content="10.3174/ajnr.A8478" />
<meta name="citation_article_type" content="Research Article" />
<meta name="citation_section" content="NEUROINTERVENTION" />
<meta name="citation_author" content="Constantin Hecker" />
<meta name="citation_author_institution" content="aFrom the Institute of Neurointervention (C. Hecker, C. Hufnagl, A.O., C.J.G., M.K-O.), Paracelsus Medical University, Salzburg, Austria" />
<meta name="citation_author_institution" content="bDepartment of Neurosurgery (C. Hecker, C.J.G.), Paracelsus Medical University, Salzburg, Austria" />
<meta name="citation_author_orcid" content="https://orcid.org/0000-0003-0521-8570" />
<meta name="citation_author" content="Clemens Hufnagl" />
<meta name="citation_author_institution" content="aFrom the Institute of Neurointervention (C. Hecker, C. Hufnagl, A.O., C.J.G., M.K-O.), Paracelsus Medical University, Salzburg, Austria" />
<meta name="citation_author" content="Andreas Oellerer" />
<meta name="citation_author_institution" content="aFrom the Institute of Neurointervention (C. Hecker, C. Hufnagl, A.O., C.J.G., M.K-O.), Paracelsus Medical University, Salzburg, Austria" />
<meta name="citation_author_institution" content="dDepartment of Neuroradiology (A.O.), Paracelsus Medical University, Salzburg, Austria" />
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<meta name="twitter:title" content="The Artisse Intrasaccular Device: A New Intrasaccular Flow Diverter for the Treatment of Cerebral Aneurysms" />
<meta name="twitter:card" content="summary" />
<meta name="twitter:description" content="BACKGROUND AND PURPOSE: This animal study was designed to evaluate in vivo the acute and short-term safety and efficacy of the new Artisse intrasaccular device (ISD) for aneurysm occlusion and to gain knowledge about the behavior in the aneurysms.

MATERIALS AND METHODS: The device was implanted in 7 white New Zealand rabbits with bifurcation aneurysms. Immediate and 90-day angiographic follow-up as well as histologic and scanning electron microscope imaging were evaluated.

RESULTS: Immediate postinterventional angiograms showed excellent flow reduction in all aneurysms. Progressive improvements of occlusion rate could be observed in 5 of 7 aneurysms. One device migration was noted due to undersizing, resulting in corresponding worsening of occlusion rate. Three-month microscopic examinations demonstrated excellent biocompatibility. Notably, the Artisse ISD showed increased connective tissue formation within the aneurysm sac, which correlated with the angiographic results.

CONCLUSIONS: The new Artisse ISD adapted well to aneurysm morphology and created immediate contrast stasis and excellent neck coverage. While angiographic results showed only moderate adequate occlusion at 3 months, histologic data showed excellent biocompatibility and good connective tissue formation within the aneurysm sac in all aneurysms treated with the Artisse ISD. Sizing and correct positioning appear to be crucial for adequate occlusion.

DAPT
:   dual antiplatelet therapy
DFT
:   drawn-filled tubing
ID
:   inner diameter
IFD
:   intrasaccular flow diverter
ISD
:   intrasaccular device
mRRC
:   modified Raymond-Roy classification
NiTi
:   Nitinol
OKM
:   O’Kelly-Marotta scale
WEB
:   Woven Endobridge" />
<meta name="og-title" property="og:title" content="The Artisse Intrasaccular Device: A New Intrasaccular Flow Diverter for the Treatment of Cerebral Aneurysms" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/early/2024/12/20/ajnr.A8478" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: This animal study was designed to evaluate in vivo the acute and short-term safety and efficacy of the new Artisse intrasaccular device (ISD) for aneurysm occlusion and to gain knowledge about the behavior in the aneurysms.

MATERIALS AND METHODS: The device was implanted in 7 white New Zealand rabbits with bifurcation aneurysms. Immediate and 90-day angiographic follow-up as well as histologic and scanning electron microscope imaging were evaluated.

RESULTS: Immediate postinterventional angiograms showed excellent flow reduction in all aneurysms. Progressive improvements of occlusion rate could be observed in 5 of 7 aneurysms. One device migration was noted due to undersizing, resulting in corresponding worsening of occlusion rate. Three-month microscopic examinations demonstrated excellent biocompatibility. Notably, the Artisse ISD showed increased connective tissue formation within the aneurysm sac, which correlated with the angiographic results.

CONCLUSIONS: The new Artisse ISD adapted well to aneurysm morphology and created immediate contrast stasis and excellent neck coverage. While angiographic results showed only moderate adequate occlusion at 3 months, histologic data showed excellent biocompatibility and good connective tissue formation within the aneurysm sac in all aneurysms treated with the Artisse ISD. Sizing and correct positioning appear to be crucial for adequate occlusion.

DAPT
:   dual antiplatelet therapy
DFT
:   drawn-filled tubing
ID
:   inner diameter
IFD
:   intrasaccular flow diverter
ISD
:   intrasaccular device
mRRC
:   modified Raymond-Roy classification
NiTi
:   Nitinol
OKM
:   O’Kelly-Marotta scale
WEB
:   Woven Endobridge" />
<meta name="og-type" property="og:type" content="article" />
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node112447--5" data-node-nid="112447" id="top-node-112447--6975330730" data-pisa="ajnr;ajnr.A8478v1" data-pisa-master="ajnr;ajnr.A8478" data-apath="/ajnr/early/2024/12/20/ajnr.A8478.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">NEUROINTERVENTION</span></span></div>
  
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      <h1 class="highwire-cite-title" id="page-title">The Artisse Intrasaccular Device: A New Intrasaccular Flow Diverter for the Treatment of Cerebral Aneurysms</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Constantin Hecker</span>, <span class="highwire-citation-author" data-delta="1">Clemens Hufnagl</span>, <span class="highwire-citation-author" data-delta="2">Andreas Oellerer</span>, <span class="highwire-citation-author" data-delta="3">Christoph J. Griessenauer</span> and <span class="highwire-citation-author" data-delta="4">Monika Killer-Oberpfalzer</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">December 2024,  </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A8478 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-112447--6975330730" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">Constantin Hecker </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Institute of Neurointervention (C. Hecker, C. Hufnagl, A.O., C.J.G., M.K-O.), Paracelsus Medical University, Salzburg, Austria</div><div class='author-affiliation'><span class='nlm-sup'>b</span>Department of Neurosurgery (C. Hecker, C.J.G.), Paracelsus Medical University, Salzburg, Austria</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Constantin%2BHecker%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Hecker%20C&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AConstantin%2BHecker%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0003-0521-8570" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for Constantin Hecker</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">Clemens Hufnagl </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Institute of Neurointervention (C. Hecker, C. Hufnagl, A.O., C.J.G., M.K-O.), Paracelsus Medical University, Salzburg, Austria</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Clemens%2BHufnagl%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Hufnagl%20C&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AClemens%2BHufnagl%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">Andreas Oellerer </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Institute of Neurointervention (C. Hecker, C. Hufnagl, A.O., C.J.G., M.K-O.), Paracelsus Medical University, Salzburg, Austria</div><div class='author-affiliation'><span class='nlm-sup'>d</span>Department of Neuroradiology (A.O.), Paracelsus Medical University, Salzburg, Austria</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Andreas%2BOellerer%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Oellerer%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AAndreas%2BOellerer%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-8563-2135" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for Andreas Oellerer</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">Christoph J. Griessenauer </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Institute of Neurointervention (C. Hecker, C. Hufnagl, A.O., C.J.G., M.K-O.), Paracelsus Medical University, Salzburg, Austria</div><div class='author-affiliation'><span class='nlm-sup'>b</span>Department of Neurosurgery (C. Hecker, C.J.G.), Paracelsus Medical University, Salzburg, Austria</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Christoph%2BJ.%2BGriessenauer%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Griessenauer%20CJ&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AChristoph%2BJ.%2BGriessenauer%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-2952-3812" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for Christoph J. Griessenauer</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">Monika Killer-Oberpfalzer </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Institute of Neurointervention (C. Hecker, C. Hufnagl, A.O., C.J.G., M.K-O.), Paracelsus Medical University, Salzburg, Austria</div><div class='author-affiliation'><span class='nlm-sup'>c</span>Department of Neurology (M.K.-O.), Paracelsus Medical University, Salzburg, Austria</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Monika%2BKiller-Oberpfalzer%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Killer-Oberpfalzer%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AMonika%2BKiller-Oberpfalzer%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0001-5572-7694" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for Monika Killer-Oberpfalzer</a></li></ul></div></div></div>  </div>

  
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    <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" data-highwire-cite-ref-tooltip-instance="highwire_reflinks_tooltip" class="content-block-markup" xmlns:xhtml="http://www.w3.org/1999/xhtml"><div class="article abstract-view "><span class="highwire-journal-article-marker-start"></span><div class="section abstract" id="abstract-1"><h2>Abstract</h2><div id="sec-1" class="subsection"><p id="p-1"><strong>BACKGROUND AND PURPOSE:</strong> This animal study was designed to evaluate in vivo the acute and short-term safety and efficacy of the new Artisse intrasaccular device (ISD) for aneurysm occlusion and to gain knowledge about the behavior in the aneurysms.</p></div><div id="sec-2" class="subsection"><p id="p-2"><strong>MATERIALS AND METHODS:</strong> The device was implanted in 7 white New Zealand rabbits with bifurcation aneurysms. Immediate and 90-day angiographic follow-up as well as histologic and scanning electron microscope imaging were evaluated.</p></div><div id="sec-3" class="subsection"><p id="p-3"><strong>RESULTS:</strong> Immediate postinterventional angiograms showed excellent flow reduction in all aneurysms. Progressive improvements of occlusion rate could be observed in 5 of 7 aneurysms. One device migration was noted due to undersizing, resulting in corresponding worsening of occlusion rate. Three-month microscopic examinations demonstrated excellent biocompatibility. Notably, the Artisse ISD showed increased connective tissue formation within the aneurysm sac, which correlated with the angiographic results.</p></div><div id="sec-4" class="subsection"><p id="p-4"><strong>CONCLUSIONS:</strong> The new Artisse ISD adapted well to aneurysm morphology and created immediate contrast stasis and excellent neck coverage. While angiographic results showed only moderate adequate occlusion at 3 months, histologic data showed excellent biocompatibility and good connective tissue formation within the aneurysm sac in all aneurysms treated with the Artisse ISD. Sizing and correct positioning appear to be crucial for adequate occlusion.</p></div></div><div class="section glossary" id="glossary-1"><h2 class="">ABBREVIATIONS:</h2><dl id="def-list-1"><dt id="def-item-1">DAPT<span class="def-item-dt-sep"></span></dt><dd>dual antiplatelet therapy<span class="def-item-dd-sep"></span></dd><dt id="def-item-2">DFT<span class="def-item-dt-sep"></span></dt><dd>drawn-filled tubing<span class="def-item-dd-sep"></span></dd><dt id="def-item-3">ID<span class="def-item-dt-sep"></span></dt><dd>inner diameter<span class="def-item-dd-sep"></span></dd><dt id="def-item-4">IFD<span class="def-item-dt-sep"></span></dt><dd>intrasaccular flow diverter<span class="def-item-dd-sep"></span></dd><dt id="def-item-5">ISD<span class="def-item-dt-sep"></span></dt><dd>intrasaccular device<span class="def-item-dd-sep"></span></dd><dt id="def-item-6">mRRC<span class="def-item-dt-sep"></span></dt><dd>modified Raymond-Roy classification<span class="def-item-dd-sep"></span></dd><dt id="def-item-7">NiTi<span class="def-item-dt-sep"></span></dt><dd>Nitinol<span class="def-item-dd-sep"></span></dd><dt id="def-item-8">OKM<span class="def-item-dt-sep"></span></dt><dd>O’Kelly-Marotta scale<span class="def-item-dd-sep"></span></dd><dt id="def-item-9">WEB<span class="def-item-dt-sep"></span></dt><dd>Woven Endobridge</dd></dl></div><div class="section fn-group" id="fn-group-1"><h2>Footnotes</h2><ul><li class="fn-financial-disclosure" id="fn-2"><p id="p-59"><a href="https://www.ajnr.org/sites/default/files/additional-assets/Disclosures/January%202025/0249.pdf">Disclosure forms</a> provided by the authors are available with the full text and PDF of this article at <a href="http://www.ajnr.org">www.ajnr.org</a>.</p></li></ul></div><ul class="copyright-statement"><li class="fn" id="copyright-statement-1">© 2025 by American Journal of Neuroradiology</li></ul><span class="highwire-journal-article-marker-end"></span></div><span class="related-urls"></span></div><a href="http://ajnr-stage2.stage.highwire.org/content/early/2024/12/20/ajnr.A8478.full" class="hw-link hw-link-article-full-text" data-icon-position="" data-hide-link-title="0">View Full Text</a></div>  </div>

  
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