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<meta name="DC.Description" content="Eight children with clinical and radiologic abnormalities consistent with periventricular leukomalacia were investigated with MR imaging of the brain that employed both inversion-recovery and T2-weighted spin-echo imaging sequences. The more precise delineation of white and gray matter on inversion-recovery images as compared with CT allows a detailed demonstration of the anatomic features of periventricular leukomalacia; specifically, a reduced quantity of white matter in the periventricular region and centrum semiovale and, in more severe cases, cavitated infarcts that replace the immediate periventricular white matter. The T2-weighted spin-echo and short inversion time inversion-recovery images demonstrated abnormally increased signal in white matter that appeared normal on CT scans and only minimally abnormal on conventional inversion-recovery images. These abnormalities most probably represent white matter gliosis that extends beyond the immediate periventricular regions.

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      <h1 class="highwire-cite-title" id="page-title">MR Imaging of Periventricular Leukomalacia in Childhood</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Olof Flodmark</span>, <span class="highwire-citation-author" data-delta="1">Brian Lupton</span>, <span class="highwire-citation-author" data-delta="2">David Li</span>, <span class="highwire-citation-author" data-delta="3">Gary K. Stimac</span>, <span class="highwire-citation-author" data-delta="4">Elke H. Roland</span>, <span class="highwire-citation-author" data-delta="5">Alan Hill</span>, <span class="highwire-citation-author" data-delta="6">Michael F. Whitfield</span> and <span class="highwire-citation-author" data-delta="7">Margaret G. Norman</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">January 1989,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">10 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(1) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">111-118; </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-13278--61352490922" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">Olof Flodmark </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>1</span> Department of Radiology, University of British Columbia Children’s Hospital, 4480 Oak St., Vancouver, B.C., Canada V6H 3V4. Address reprint requests to O. 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<p id="p-1">Eight children with clinical and radiologic abnormalities consistent with periventricular leukomalacia were investigated with MR imaging of the brain that employed both inversion-recovery and T2-weighted spin-echo imaging sequences. The more precise delineation of white and gray matter on inversion-recovery images as compared with CT allows a detailed demonstration of the anatomic features of periventricular leukomalacia; specifically, a reduced quantity of white matter in the periventricular region and centrum semiovale and, in more severe cases, cavitated infarcts that replace the immediate periventricular white matter. The T2-weighted spin-echo and short inversion time inversion-recovery images demonstrated abnormally increased signal in white matter that appeared normal on CT scans and only minimally abnormal on conventional inversion-recovery images. These abnormalities most probably represent white matter gliosis that extends beyond the immediate periventricular regions.</p>
<p id="p-2">MR recognition of cerebral white matter abnormalities associated with periventricular leukomalacia may confirm the clinical suspicion of this diagnosis in children with spastic diplegia or quadriplegia.</p>
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