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      <h1 class="highwire-cite-title" id="page-title">Visualization of Human Inner Ear Anatomy with High-Resolution MR Imaging at 7T</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">S. Naganawa</span> and <span class="highwire-citation-author" data-delta="1">S.M. Sone</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">December 2014,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">35 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(12) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">E10; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A4161 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-13827--6220542530" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">S. Naganawa </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>Department of Radiology</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=S.%2BNaganawa%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Naganawa%20S&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AS.%2BNaganawa%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-0214-613X" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for S. Naganawa</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">S.M. Sone </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Department of Otorhinolaryngology
Nagoya University Graduate School of Medicine
Nagoya, Japan</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=S.M.%2BSone%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Sone%20S&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AS.M.%2BSone%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div></div></div>  </div>

  
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    <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" data-highwire-cite-ref-tooltip-instance="highwire_reflinks_tooltip" class="content-block-markup" xmlns:xhtml="http://www.w3.org/1999/xhtml"><div class="article fulltext-view "><span class="highwire-journal-article-marker-start"></span><p id="p-1">We read with interest the article by van der Jagt et al<sup><a id="xref-ref-1-1" class="xref-bibr" href="#ref-1">1</a></sup> describing the visualization of the scala media of the cochlea in living human subjects by non-contrast-enhanced T2-weighted imaging at 7T. For recognition of the scala media with this technique, visualization of the Reissner membrane is necessary. The Reissner membrane is very thin, 4–12 μm.<sup><a id="xref-ref-2-1" class="xref-bibr" href="#ref-2">2</a></sup></p><p id="p-2">Visualization of this thin membrane in a human cadaveric specimen has been reported by using microfocus x-ray CT with 12.2-μm spatial resolution and a 9.4T small-bore MR imaging unit with 23-μm spatial resolution.<sup><a id="xref-ref-2-2" class="xref-bibr" href="#ref-2">2</a>,<a id="xref-ref-3-1" class="xref-bibr" href="#ref-3">3</a></sup> The spatial resolution used in this article on a 7T system was 300 μm. The presumed Reissner membrane shown in Fig 2 is not clear. Furthermore, there are several stripelike artifacts in the vestibule in Fig 2<em>B</em>.</p><p id="p-3">To further increase the confidence and significance of this article, verification of the visualization of the Reissner membrane by comparing non-contrast-enhanced T2-weighted imaging and contrast-enhanced FLAIR<sup><a id="xref-ref-4-1" class="xref-bibr" href="#ref-4">4</a></sup> in the same subjects might be very valuable. If the visualization of the Reissner membrane by non-contrast-enhanced MR imaging at 7T is feasible, it might be a “killer application” for its widespread use in the clinical field.</p><div class="section ref-list" id="ref-list-1"><h2 class="">References</h2><ol class="cit-list ref-use-labels"><li><span class="ref-label">1.</span><a class="rev-xref-ref" href="#xref-ref-1-1" title="View reference 1. in text" id="ref-1">↵</a>

<div class="cit ref-cit ref-journal" id="cit-35.12.E10.1"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">van der Jagt</span>  <span class="cit-name-given-names">MA</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Brink</span>  <span class="cit-name-given-names">WM</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Versluis</span>  <span class="cit-name-given-names">MJ</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Visualization of human inner ear anatomy with high-resolution MR imaging at 7T: initial clinical assessment</span>. <abbr class="cit-jnl-abbrev">AJNR Am J Neuroradiol</abbr> <span class="cit-pub-date">2014</span> 
<span class="cit-month">Aug</span> 
<span class="cit-day">21</span>. <span class="cit-comment">[Epub ahead of print]</span></cite></div><div class="cit-extra"></div></div></li><li><span class="ref-label">2.</span><a class="rev-xref-ref" href="#xref-ref-2-1" title="View reference 2. in text" id="ref-2">↵</a>

<div class="cit ref-cit ref-journal" id="cit-35.12.E10.2" data-doi="10.1016/j.amjoto.2008.07.012"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Shibata</span>  <span class="cit-name-given-names">T</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Matsumoto</span>  <span class="cit-name-given-names">S</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Agishi</span>  <span class="cit-name-given-names">T</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Visualization of Reissner membrane and the spiral ganglion in human fetal cochlea by micro-computed tomography</span>. <abbr class="cit-jnl-abbrev">Am J Otolaryngol</abbr> <span class="cit-pub-date">2009</span>;<span class="cit-vol">30</span>:<span class="cit-fpage">112</span>–<span class="cit-lpage">20</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1016/j.amjoto.2008.07.012&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=19239953&amp;link_type=MED&amp;atom=%2Fajnr%2F35%2F12%2FE10.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">3.</span><a class="rev-xref-ref" href="#xref-ref-3-1" title="View reference 3. in text" id="ref-3">↵</a>

<div class="cit ref-cit ref-journal" id="cit-35.12.E10.3" data-doi="10.1097/00005537-200210000-00005"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Silver</span>  <span class="cit-name-given-names">RD</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Djalilian</span>  <span class="cit-name-given-names">HR</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Levine</span>  <span class="cit-name-given-names">SC</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">High-resolution magnetic resonance imaging of human cochlea</span>. <abbr class="cit-jnl-abbrev">Laryngoscope</abbr> <span class="cit-pub-date">2002</span>;<span class="cit-vol">112</span>:<span class="cit-fpage">1737</span>–<span class="cit-lpage">41</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1097/00005537-200210000-00005&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=12368606&amp;link_type=MED&amp;atom=%2Fajnr%2F35%2F12%2FE10.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><span class="ref-label">4.</span><a class="rev-xref-ref" href="#xref-ref-4-1" title="View reference 4. in text" id="ref-4">↵</a>

<div class="cit ref-cit ref-journal" id="cit-35.12.E10.4" data-doi="10.2463/mrms.9.237"><div class="cit-metadata"><ol class="cit-auth-list"><li>
</li><li><span class="cit-auth"><span class="cit-name-surname">Naganawa</span>  <span class="cit-name-given-names">S</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Yamazaki</span>  <span class="cit-name-given-names">M</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Kawai</span>  <span class="cit-name-given-names">H</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Visualization of endolymphatic hydrops in Ménière's disease with single-dose intravenous gadolinium-based contrast media using heavily T(2)-weighted 3D-FLAIR</span>. <abbr class="cit-jnl-abbrev">Magn Reson Med Sci</abbr> <span class="cit-pub-date">2010</span>;<span class="cit-vol">9</span>:<span class="cit-fpage">237</span>–<span class="cit-lpage">42</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.2463/mrms.9.237&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=21187694&amp;link_type=MED&amp;atom=%2Fajnr%2F35%2F12%2FE10.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li></ol></div><ul class="copyright-statement"><li class="fn" id="copyright-statement-1">© 2014 by American Journal of Neuroradiology</li></ul><span class="highwire-journal-article-marker-end"></span></div><span class="related-urls"></span></div></div>  </div>

  
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 35</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 12 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Dec 2014 </div></div>
      
      
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