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      <h1 class="highwire-cite-title" id="page-title">Twinkling Artifact on Intracerebral Color Doppler Sonography</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Haleem G. Khan</span>, <span class="highwire-citation-author" data-delta="1">Philippe Gailloud</span>, <span class="highwire-citation-author" data-delta="2">Jean-Baptiste Martin</span>, <span class="highwire-citation-author" data-delta="3">Nathalie Khaw</span>, <span class="highwire-citation-author" data-delta="4">Luca Spadola</span>, <span class="highwire-citation-author" data-delta="5">Daniel A. Rüfenacht</span> and <span class="highwire-citation-author" data-delta="6">François Terrier</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">February 1999,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">20 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(2) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">246-247; </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-2286--61630949606" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">Haleem G. Khan </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Haleem%2BG.%2BKhan%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Khan%20HG&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AHaleem%2BG.%2BKhan%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">Philippe Gailloud </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Philippe%2BGailloud%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Gailloud%20P&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3APhilippe%2BGailloud%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">Jean-Baptiste Martin </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Jean-Baptiste%2BMartin%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Martin%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AJean-Baptiste%2BMartin%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">Nathalie Khaw </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Nathalie%2BKhaw%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Khaw%20N&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3ANathalie%2BKhaw%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">Luca Spadola </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Luca%2BSpadola%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Spadola%20L&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3ALuca%2BSpadola%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-5"><div class="author-tooltip-name">Daniel A. Rüfenacht </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Daniel%2BA.%2BR%C3%BCfenacht%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=R%C3%BCfenacht%20DA&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3ADaniel%2BA.%2BR%25C3%25BCfenacht%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-6"><div class="author-tooltip-name">François Terrier </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Fran%C3%A7ois%2BTerrier%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Terrier%20F&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AFran%25C3%25A7ois%2BTerrier%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div></div></div>  </div>

  
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    <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" data-highwire-cite-ref-tooltip-instance="highwire_reflinks_tooltip" class="content-block-markup" xmlns:xhtml="http://www.w3.org/1999/xhtml"><div class="article fulltext-view"><span class="highwire-journal-article-marker-start"></span><div class="section abstract" id="abstract-1"><h2>Abstract</h2><p id="p-1">Summary: Transcranial Doppler sonography shows potential as a noninvasive technique for long-term follow-up of treated intracranial saccular aneurysms. This technical note describes a color Doppler artifact related to microcoil architecture that might represent a potential pitfall in transcranial Doppler sonographic evaluation of aneurysmal cavity thrombosis, since it may be wrongly interpreted as residual flow or aneurysmal cavity recanalization.</p></div><div class="section" id="sec-1"><p id="p-2">Transcranial Doppler sonography is a promising noninvasive technique for the detection and posttherapeutic follow-up of intracranial saccular aneurysms. This technical note describes a color Doppler artifact related to microcoil architecture that might represent a potential pitfall in transcranial Doppler sonographic evaluation of aneurysmal cavity thrombosis.</p></div><div class="section" id="sec-2"><h2>Case Report</h2><p id="p-3">Cerebral digital subtraction angiography was performed in a 45-year-old patient with subarachnoid hemorrhage proved at CT. Three saccular aneurysms were discovered: a broad-based, irregularly shaped aneurysm of the anterior communicating artery (ACoA), a 3-mm aneurysm of the right anterior choroidal artery (AChA) (<a id="xref-fig-1-1" class="xref-fig" href="#F1">Fig 1</a>), and a 1-mm aneurysm of the right middle cerebral artery (MCA) bifurcation (<a id="xref-fig-1-2" class="xref-fig" href="#F1">Fig 1</a>). The ACoA aneurysm was considered the source of the hemorrhage, and surgical clipping was performed; it was decided to treat the AChA aneurysm through an endovascular approach. The very small MCA aneurysm was left untreated. The AChA aneurysm was successfully embolized with a single Guglielmi detachable coil (diameter, 3 mm; length, 40 mm) (GDC-10 soft, Target Therapeutics, Fremont, CA) (<a id="xref-fig-2-1" class="xref-fig" href="#F2">Fig 2</a>). Transcranial Doppler sonography was performed through a right temporal window before and after endovascular treatment as part of the embolization protocol adopted in our institution (<a id="xref-fig-2-2" class="xref-fig" href="#F2">Figs 3</a> and <a id="xref-fig-3-1" class="xref-fig" href="#F3">4</a>). At posttherapeutic transcranial Doppler sonography, the coil appeared as a hyperechoic structure with shadowing, and a color signal was noted as a rapidly changing mixture of red and blue behind the coil (<a id="xref-fig-3-2" class="xref-fig" href="#F3">Fig 4</a>). No flow was noted close to or in the aneurysm, whereas a digital subtraction angiogram obtained immediately before transcranial Doppler sonography showed that the aneurysmal cavity was completely excluded from the cerebral circulation. As a complement to this clinical observation, an in vitro essay consisting of insonation of a Guglielmi detachable coil enclosed between two hydrated agar sheets (Sonar-Aid, Geistlich-Pharma, Switzerland) was performed, allowing us to reproduce the artifactual color signal (<a id="xref-fig-3-3" class="xref-fig" href="#F3">Fig 5</a>).</p><div id="F1" class="fig pos-float odd"><div class="highwire-figure"><div class="fig-inline-img-wrapper"><div class="fig-inline-img"><a href="http://ajnr-stage2.stage.highwire.org/content/ajnr/20/2/246/F1.large.jpg?width=800&amp;height=600&amp;carousel=1" title="Digital subtraction angiogram, superselective study of the right internal carotid artery, arterial phase, lateral projection, displays the MCA bifurcation. A, A small saccular aneurysm (arrow) is seen at the right anterior choroidal artery origin. Note also the minute aneurysm at the MCA bifurcation.B, On late arterial phase image, a characteristic aneurysmal inflow-outflow pattern (&#x201C;yin-yang&#x201D;) may be observed." class="highwire-fragment fragment-images colorbox-load" rel="gallery-fragment-images-233298267" data-figure-caption="&lt;div class=&quot;highwire-markup&quot;&gt;Digital subtraction angiogram, superselective study of the right internal carotid artery, arterial phase, lateral projection, displays the MCA bifurcation. A, A small saccular aneurysm (arrow) is seen at the right anterior choroidal artery origin. Note also the minute aneurysm at the MCA bifurcation.B, On late arterial phase image, a characteristic aneurysmal inflow-outflow pattern (&#x201C;yin-yang&#x201D;) may be observed.&lt;/div&gt;" data-icon-position="" data-hide-link-title="0"><span class="hw-responsive-img"><img class="highwire-fragment fragment-image lazyload" alt="fig 1." src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="http://ajnr-stage2.stage.highwire.org/content/ajnr/20/2/246/F1.medium.gif" width="650" height="317"/><noscript><img class="highwire-fragment fragment-image" alt="fig 1." src="http://ajnr-stage2.stage.highwire.org/content/ajnr/20/2/246/F1.medium.gif" width="650" height="317"/></noscript></span></a></div></div><ul class="highwire-figure-links inline"><li class="download-fig first"><a href="http://ajnr-stage2.stage.highwire.org/content/ajnr/20/2/246/F1.large.jpg?download=true" class="highwire-figure-link highwire-figure-link-download" title="Download fig 1." data-icon-position="" data-hide-link-title="0">Download figure</a></li><li class="new-tab"><a href="http://ajnr-stage2.stage.highwire.org/content/ajnr/20/2/246/F1.large.jpg" class="highwire-figure-link highwire-figure-link-newtab" target="_blank" data-icon-position="" data-hide-link-title="0">Open in new tab</a></li><li class="download-ppt last"><a href="/highwire/powerpoint/15890" class="highwire-figure-link highwire-figure-link-ppt" data-icon-position="" data-hide-link-title="0">Download powerpoint</a></li></ul></div><div class="fig-caption" xmlns:xhtml="http://www.w3.org/1999/xhtml"><span class="fig-label"><span class="sc">fig</span> 1.</span> <p id="p-7" class="first-child">Digital subtraction angiogram, superselective study of the right internal carotid artery, arterial phase, lateral projection, displays the MCA bifurcation. </p><p id="p-8"><em>A,</em> A small saccular aneurysm (<em>arrow</em>) is seen at the right anterior choroidal artery origin. Note also the minute aneurysm at the MCA bifurcation.</p><p id="p-9"><em>B,</em> On late arterial phase image, a characteristic aneurysmal inflow-outflow pattern (“yin-yang”) may be observed.</p><div class="sb-div caption-clear"></div></div></div><div id="F2" class="fig pos-float odd"><div class="highwire-figure"><div class="fig-inline-img-wrapper"><div class="fig-inline-img"><a href="http://ajnr-stage2.stage.highwire.org/content/ajnr/20/2/246/F2.large.jpg?width=800&amp;height=600&amp;carousel=1" title="Digital subtraction angiogram, selective study of the right internal carotid artery, arterial phase, lateral projection. After treatment with a single detachable coil, the aneurysmal cavity is totally excluded from the cerebral circulation (arrows). fig 3.&#x2003;Transcranial Doppler sonogram, right transtemporal approach. Before treatment, a color Doppler signal is seen within the aneurysmal cavity (arrow). It also shows the typical &#x201C;yin- yang&#x201D; appearance, corresponding to the inflow and outflow regions of the aneurysm." class="highwire-fragment fragment-images colorbox-load" rel="gallery-fragment-images-233298267" data-figure-caption="&lt;div class=&quot;highwire-markup&quot;&gt;Digital subtraction angiogram, selective study of the right internal carotid artery, arterial phase, lateral projection. After treatment with a single detachable coil, the aneurysmal cavity is totally excluded from the cerebral circulation (arrows). fig 3.&#x2003;Transcranial Doppler sonogram, right transtemporal approach. Before treatment, a color Doppler signal is seen within the aneurysmal cavity (arrow). It also shows the typical &#x201C;yin- yang&#x201D; appearance, corresponding to the inflow and outflow regions of the aneurysm.&lt;/div&gt;" data-icon-position="" data-hide-link-title="0"><span class="hw-responsive-img"><img class="highwire-fragment fragment-image lazyload" alt="fig 2." src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="http://ajnr-stage2.stage.highwire.org/content/ajnr/20/2/246/F2.medium.gif" width="650" height="312"/><noscript><img class="highwire-fragment fragment-image" alt="fig 2." src="http://ajnr-stage2.stage.highwire.org/content/ajnr/20/2/246/F2.medium.gif" width="650" height="312"/></noscript></span></a></div></div><ul class="highwire-figure-links inline"><li class="download-fig first"><a href="http://ajnr-stage2.stage.highwire.org/content/ajnr/20/2/246/F2.large.jpg?download=true" class="highwire-figure-link highwire-figure-link-download" title="Download fig 2." data-icon-position="" data-hide-link-title="0">Download figure</a></li><li class="new-tab"><a href="http://ajnr-stage2.stage.highwire.org/content/ajnr/20/2/246/F2.large.jpg" class="highwire-figure-link highwire-figure-link-newtab" target="_blank" data-icon-position="" data-hide-link-title="0">Open in new tab</a></li><li class="download-ppt last"><a href="/highwire/powerpoint/15892" class="highwire-figure-link highwire-figure-link-ppt" data-icon-position="" data-hide-link-title="0">Download powerpoint</a></li></ul></div><div class="fig-caption"><span class="fig-label"><span class="sc">fig</span> 2.</span> <p id="p-10" class="first-child">Digital subtraction angiogram, selective study of the right internal carotid artery, arterial phase, lateral projection. After treatment with a single detachable coil, the aneurysmal cavity is totally excluded from the cerebral circulation (<em>arrows</em>). </p><p id="p-11"><span class="sc">fig</span> 3. Transcranial Doppler sonogram, right transtemporal approach. Before treatment, a color Doppler signal is seen within the aneurysmal cavity (<em>arrow</em>). It also shows the typical “yin- yang” appearance, corresponding to the inflow and outflow regions of the aneurysm.</p><div class="sb-div caption-clear"></div></div></div><div id="F3" class="fig pos-float odd"><div class="highwire-figure"><div class="fig-inline-img-wrapper"><div class="fig-inline-img"><a href="http://ajnr-stage2.stage.highwire.org/content/ajnr/20/2/246/F3.large.jpg?width=800&amp;height=600&amp;carousel=1" title="Transcranial Doppler sonogram, right transtemporal approach. After treatment, a twinkling artifact (arrow) is observed immediately behind the hyperechoic signal of the microcoil. fig 5.&#x2003;In vitro insonation of a Guglielmi detachable coil enclosed within two hydrated agar sheets. Color Doppler image shows the hyperechoic structure of the coil (arrow) and the twinkling artifact (arrowhead)." class="highwire-fragment fragment-images colorbox-load" rel="gallery-fragment-images-233298267" data-figure-caption="&lt;div class=&quot;highwire-markup&quot;&gt;Transcranial Doppler sonogram, right transtemporal approach. After treatment, a twinkling artifact (arrow) is observed immediately behind the hyperechoic signal of the microcoil. fig 5.&#x2003;In vitro insonation of a Guglielmi detachable coil enclosed within two hydrated agar sheets. Color Doppler image shows the hyperechoic structure of the coil (arrow) and the twinkling artifact (arrowhead).&lt;/div&gt;" data-icon-position="" data-hide-link-title="0"><span class="hw-responsive-img"><img class="highwire-fragment fragment-image lazyload" alt="fig 4." src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="http://ajnr-stage2.stage.highwire.org/content/ajnr/20/2/246/F3.medium.gif" width="650" height="313"/><noscript><img class="highwire-fragment fragment-image" alt="fig 4." src="http://ajnr-stage2.stage.highwire.org/content/ajnr/20/2/246/F3.medium.gif" width="650" height="313"/></noscript></span></a></div></div><ul class="highwire-figure-links inline"><li class="download-fig first"><a href="http://ajnr-stage2.stage.highwire.org/content/ajnr/20/2/246/F3.large.jpg?download=true" class="highwire-figure-link highwire-figure-link-download" title="Download fig 4." data-icon-position="" data-hide-link-title="0">Download figure</a></li><li class="new-tab"><a href="http://ajnr-stage2.stage.highwire.org/content/ajnr/20/2/246/F3.large.jpg" class="highwire-figure-link highwire-figure-link-newtab" target="_blank" data-icon-position="" data-hide-link-title="0">Open in new tab</a></li><li class="download-ppt last"><a href="/highwire/powerpoint/15894" class="highwire-figure-link highwire-figure-link-ppt" data-icon-position="" data-hide-link-title="0">Download powerpoint</a></li></ul></div><div class="fig-caption"><span class="fig-label"><span class="sc">fig</span> 4.</span> <p id="p-12" class="first-child">Transcranial Doppler sonogram, right transtemporal approach. After treatment, a twinkling artifact (<em>arrow</em>) is observed immediately behind the hyperechoic signal of the microcoil. </p><p id="p-13"><span class="sc">fig</span> 5. In vitro insonation of a Guglielmi detachable coil enclosed within two hydrated agar sheets. Color Doppler image shows the hyperechoic structure of the coil (<em>arrow</em>) and the twinkling artifact (<em>arrowhead</em>).</p><div class="sb-div caption-clear"></div></div></div></div><div class="section" id="sec-3"><h2>Discussion</h2><p id="p-4">The color artifact reported herein corresponds to the color Doppler twinkling artifact described by Rahmouni et al <a id="xref-ref-1-1" class="xref-bibr" href="#ref-1">(1)</a>. These authors showed that artifactual color appears to be generated at random, strongly reflecting a medium composed of individual reflectors. Color is not always restricted to blood flow and can be seen adjacent to areas of severe vascular stenosis <a id="xref-ref-2-1" class="xref-bibr" href="#ref-2">(2)</a> or in echo-free regions without flow <a id="xref-ref-3-1" class="xref-bibr" href="#ref-3">(3)</a>. In the reported observation, no flow spectrum could be recorded in the color areas, and the spectrum was composed of close vertical bands with no outer wrapping. This artifact has been observed in the abdominal field, particularly in the detection of renal or ureteral calculi, but its potential interest in locating intracerebral coils has, to our knowledge, not been reported previously.</p></div><div class="section" id="sec-4"><h2>Conclusion</h2><p id="p-5">Transcranial Doppler sonography shows potential as a noninvasive technique for long-term follow-up of treated intracranial saccular aneurysms. The artifact described herein thus seems important to recognize, as it could be mistaken for residual flow or aneurysmal cavity recanalization.</p></div><div class="section fn-group" id="fn-group-1"><h2>Footnotes</h2><ul><li class="fn" id="fn-1"><p id="p-6"><a class="rev-xref" href="#xref-fn-1-1">↵</a><span class="fn-label">1</span> Address reprint requests to Haleem G. Khan, MD.</p></li></ul></div><div class="section ref-list" id="ref-list-1"><h2>References</h2><ol class="cit-list"><li><a class="rev-xref-ref" href="#xref-ref-1-1" title="View reference 1 in text" id="ref-1">↵</a><div class="cit ref-cit ref-other" id="cit-20.2.246.1"><div class="cit-metadata"><cite>Rahmouni A, Bargoin R, Herment A,  et al.   <strong>Color Doppler twinkling artifact in hyperechoic regions.</strong>  <span class="cit-source">Radiology</span>  <span class="cit-pub-date">1996</span>;<span class="cit-vol">199</span>:<span class="cit-fpage">269</span>-271</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=8633158&amp;link_type=MED&amp;atom=%2Fajnr%2F20%2F2%2F246.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-2-1" title="View reference 2 in text" id="ref-2">↵</a><div class="cit ref-cit ref-other" id="cit-20.2.246.2"><div class="cit-metadata"><cite>Middleton WD, Erikson S, Melson GL.   <strong>Perivascular color artifact: pathologic significance and appearance on color Doppler US images.</strong>  <span class="cit-source">Radiology</span>  <span class="cit-pub-date">1989</span>;<span class="cit-vol">171</span>:<span class="cit-fpage">647</span>-652</cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=2655000&amp;link_type=MED&amp;atom=%2Fajnr%2F20%2F2%2F246.atom" class="cit-ref-sprinkles cit-ref-sprinkles-medline"><span>PubMed</span></a></div></div></li><li><a class="rev-xref-ref" href="#xref-ref-3-1" title="View reference 3 in text" id="ref-3">↵</a><div class="cit ref-cit ref-other" id="cit-20.2.246.3"><div class="cit-metadata"><cite>Mitchell DG, Burns P, Needleman L.   <strong>Color Doppler artifact in anechoic regions.</strong>  <span class="cit-source">J Ultrasound Med</span>  <span class="cit-pub-date">1990</span>;<span class="cit-vol">9</span>:<span class="cit-fpage">255</span>-260</cite></div><div class="cit-extra"><a href="/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6NToidWx0cmEiO3M6NToicmVzaWQiO3M6NzoiOS81LzI1NSI7czo0OiJhdG9tIjtzOjE5OiIvYWpuci8yMC8yLzI0Ni5hdG9tIjt9czo4OiJmcmFnbWVudCI7czowOiIiO30=" class="cit-ref-sprinkles cit-ref-sprinkles-ijlink"><span><span class="cit-reflinks-abstract">Abstract</span></span></a></div></div></li></ol></div><ul class="history-list"><li xmlns:hwp="http://schema.highwire.org/Journal" class="received" hwp:start="1998-01-22"><span class="received-label">Received </span>January 22, 1998.</li></ul><ul class="copyright-statement"><li class="fn" id="copyright-statement-1">Copyright © American Society of Neuroradiology</li></ul><span class="highwire-journal-article-marker-end"></span></div><span class="related-urls"></span></div></div>  </div>

  
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 20</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 2 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Feb 1999 </div></div>
      
      
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      <div class="highwire-cite-title">Twinkling Artifact on Intracerebral Color Doppler Sonography</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Haleem G.</span> <span class="nlm-surname">Khan</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Philippe</span> <span class="nlm-surname">Gailloud</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">Jean-Baptiste</span> <span class="nlm-surname">Martin</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Nathalie</span> <span class="nlm-surname">Khaw</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Luca</span> <span class="nlm-surname">Spadola</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Daniel A.</span> <span class="nlm-surname">Rüfenacht</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">François</span> <span class="nlm-surname">Terrier</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Feb 1999, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">20 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(2) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">246-247; </span></div>
  
  
  
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      <div class="highwire-cite-title">Twinkling Artifact on Intracerebral Color Doppler Sonography</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Haleem G.</span> <span class="nlm-surname">Khan</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Philippe</span> <span class="nlm-surname">Gailloud</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">Jean-Baptiste</span> <span class="nlm-surname">Martin</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Nathalie</span> <span class="nlm-surname">Khaw</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Luca</span> <span class="nlm-surname">Spadola</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Daniel A.</span> <span class="nlm-surname">Rüfenacht</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">François</span> <span class="nlm-surname">Terrier</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Feb 1999, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">20 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(2) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">246-247; </span></div>
  
  
  
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