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<meta name="DC.Title" content="Brain MR imaging in children with developmental retardation of unknown cause: results in 76 cases." />
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<meta name="DC.Description" content="Seventy-six children with developmental retardation of unknown cause underwent MR imaging of the brain. Twenty-one (28%) had positive MR findings, including nine with atrophy, six with delayed myelination, four with multiple focal white matter lesions, three with hypoplastic white matter, and three with migration abnormalities. The frequency of abnormality was highest in nonautistic children with associated neurologic physical findings (61%) but was also significant in nonautistic children without neurologic findings (23%). We did not detect abnormalities on MR images of autistic retarded children. Delayed myelination and migration abnormalities were the predominant abnormalities in children with associated neurologic findings, whereas focal white matter lesions were more common in children without neurologic findings. Abnormalities were significantly more common in children with a small head circumference. Although MR did not have any effect on treatment or prognosis, it did aid the clinician in family counseling. MR will reveal brain abnormalities in about one third of nonautistic children with developmental retardation of unknown cause, and more often in those with neurologic deficits, seizures, or a small head size." />
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<meta name="twitter:description" content="Seventy-six children with developmental retardation of unknown cause underwent MR imaging of the brain. Twenty-one (28%) had positive MR findings, including nine with atrophy, six with delayed myelination, four with multiple focal white matter lesions, three with hypoplastic white matter, and three with migration abnormalities. The frequency of abnormality was highest in nonautistic children with associated neurologic physical findings (61%) but was also significant in nonautistic children without neurologic findings (23%). We did not detect abnormalities on MR images of autistic retarded children. Delayed myelination and migration abnormalities were the predominant abnormalities in children with associated neurologic findings, whereas focal white matter lesions were more common in children without neurologic findings. Abnormalities were significantly more common in children with a small head circumference. Although MR did not have any effect on treatment or prognosis, it did aid the clinician in family counseling. MR will reveal brain abnormalities in about one third of nonautistic children with developmental retardation of unknown cause, and more often in those with neurologic deficits, seizures, or a small head size." />
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<meta name="og-description" property="og:description" content="Seventy-six children with developmental retardation of unknown cause underwent MR imaging of the brain. Twenty-one (28%) had positive MR findings, including nine with atrophy, six with delayed myelination, four with multiple focal white matter lesions, three with hypoplastic white matter, and three with migration abnormalities. The frequency of abnormality was highest in nonautistic children with associated neurologic physical findings (61%) but was also significant in nonautistic children without neurologic findings (23%). We did not detect abnormalities on MR images of autistic retarded children. Delayed myelination and migration abnormalities were the predominant abnormalities in children with associated neurologic findings, whereas focal white matter lesions were more common in children without neurologic findings. Abnormalities were significantly more common in children with a small head circumference. Although MR did not have any effect on treatment or prognosis, it did aid the clinician in family counseling. MR will reveal brain abnormalities in about one third of nonautistic children with developmental retardation of unknown cause, and more often in those with neurologic deficits, seizures, or a small head size." />
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      <h1 class="highwire-cite-title" id="page-title">Brain MR imaging in children with developmental retardation of unknown cause: results in 76 cases.</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">B O Kjos</span>, <span class="highwire-citation-author" data-delta="1">R Umansky</span> and <span class="highwire-citation-author" data-delta="2">A J Barkovich</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">September 1990,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">11 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(5) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1035-1040; </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-4874--61713139164" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">B O Kjos </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'>Magnetic Imaging Affiliates, Oakland, CA 94609.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=B%2BO%2BKjos%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Kjos%20BO&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AB%2BO%2BKjos%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">R Umansky </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'>Magnetic Imaging Affiliates, Oakland, CA 94609.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=R%2BUmansky%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Umansky%20R&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AR%2BUmansky%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">A J Barkovich </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'>Magnetic Imaging Affiliates, Oakland, CA 94609.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A%2BJ%2BBarkovich%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Barkovich%20AJ&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AA%2BJ%2BBarkovich%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div></div></div>  </div>

  
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 11</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 5 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Sep 1990 </div></div>
      
      
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      <div class="highwire-cite-title">Brain MR imaging in children with developmental retardation of unknown cause: results in 76 cases.</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">B O</span> <span class="nlm-surname">Kjos</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">R</span> <span class="nlm-surname">Umansky</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">A J</span> <span class="nlm-surname">Barkovich</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Sep 1990, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">11 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(5) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1035-1040; </span></div>
  
  
  
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