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<meta name="DC.Title" content="Angioplasty and Stenting of Atherosclerotic Middle Cerebral Arteries with Wingspan: Evaluation of Clinical Outcome, Restenosis, and Procedure Outcome" />
<meta name="DC.Identifier" content="10.3174/ajnr.A2363" />
<meta name="DC.Date" content="2011-03-24" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: MCA is a common location of intracranial stenosis. It is relatively more peripherally located and of a smaller caliber, and could therefore be a site technically more challenging and risky for angioplasty and stenting. The study aimed to evaluate the clinical outcome, restenosis rate, and procedural safety of Wingspan stent placement for atherosclerosis in the MCA compared with stenosis in other arteries.

MATERIALS AND METHODS: Patients who underwent Wingspan stent placement for symptomatic intracranial stenosis of ≥70% (or stenosis of ≥50% for recurrent ischemia despite medical therapy) were recruited prospectively and allocated into a study group (MCA stenosis, n = 35) and a control group (other stenosis, n = 25). Primary end points were the following: 1) all stroke or death rate at 1 year, and 2) significant in-stent restenosis rate at 1 year. Secondary end points were the following: 1) periprocedural complications within 24 hours, rate of TIA during the procedure, all stroke or death rate within 30 days; and 2) the inability to complete the procedure due to technical problems.

RESULTS: Results of study group versus the control group were the following: degree of stenosis, 78.4 ± 10.9% versus 72.5 ± 11.2% ( P value = .0456); diameter of stenosis, 0.6 ± 0.3 versus 1.0 ± 0.5 mm ( P = .0017); all stroke or death rate at 1 year, 14.3% versus 12% (OR = 1.22); in-stent restenosis rate at 1 year, 10% versus 10.5% (OR = 1.05); periprocedural complication rate at 24 hours, 2.9% versus 4% (OR = 0.70); TIA rate during the procedure, 8.6% versus 4% (OR = 2.25); all stroke or death rate at 30 days, 5.7% versus 12% (OR = 0.44); and technical failure rate, 2.9% versus 0%.

CONCLUSIONS: In this study, there were no significant differences in procedural safety, patient outcome, and restenosis rates of stent placement between the group with MCA stenosis and the group with stenoses located at other sites." />
<meta name="DC.Contributor" content="S.C.H. Yu" />
<meta name="DC.Contributor" content="T.W.H. Leung" />
<meta name="DC.Contributor" content="K.T. Lee" />
<meta name="DC.Contributor" content="J.W.Y. Hui" />
<meta name="DC.Contributor" content="L.K.S. Wong" />
<meta name="article:published_time" content="2011-03-23" />
<meta name="article:section" content="INTERVENTIONAL" />
<meta name="citation_title" content="Angioplasty and Stenting of Atherosclerotic Middle Cerebral Arteries with Wingspan: Evaluation of Clinical Outcome, Restenosis, and Procedure Outcome" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;MCA is a common location of intracranial stenosis. It is relatively more peripherally located and of a smaller caliber, and could therefore be a site technically more challenging and risky for angioplasty and stenting. The study aimed to evaluate the clinical outcome, restenosis rate, and procedural safety of Wingspan stent placement for atherosclerosis in the MCA compared with stenosis in other arteries.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;Patients who underwent Wingspan stent placement for symptomatic intracranial stenosis of ≥70% (or stenosis of ≥50% for recurrent ischemia despite medical therapy) were recruited prospectively and allocated into a study group (MCA stenosis, &lt;i&gt;n&lt;/i&gt; = 35) and a control group (other stenosis, &lt;i&gt;n&lt;/i&gt; = 25). Primary end points were the following: 1) all stroke or death rate at 1 year, and 2) significant in-stent restenosis rate at 1 year. Secondary end points were the following: 1) periprocedural complications within 24 hours, rate of TIA during the procedure, all stroke or death rate within 30 days; and 2) the inability to complete the procedure due to technical problems.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;Results of study group versus the control group were the following: degree of stenosis, 78.4 ± 10.9% versus 72.5 ± 11.2% (&lt;i&gt;P&lt;/i&gt; value = .0456); diameter of stenosis, 0.6 ± 0.3 versus 1.0 ± 0.5 mm (&lt;i&gt;P&lt;/i&gt; = .0017); all stroke or death rate at 1 year, 14.3% versus 12% (OR = 1.22); in-stent restenosis rate at 1 year, 10% versus 10.5% (OR = 1.05); periprocedural complication rate at 24 hours, 2.9% versus 4% (OR = 0.70); TIA rate during the procedure, 8.6% versus 4% (OR = 2.25); all stroke or death rate at 30 days, 5.7% versus 12% (OR = 0.44); and technical failure rate, 2.9% versus 0%.&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;In this study, there were no significant differences in procedural safety, patient outcome, and restenosis rates of stent placement between the group with MCA stenosis and the group with stenoses located at other sites.&lt;/p&gt;" />
<meta name="citation_journal_title" content="American Journal of Neuroradiology" />
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<meta name="citation_publication_date" content="2011/03/23" />
<meta name="citation_mjid" content="ajnr;ajnr.A2363v1" />
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<meta name="citation_article_type" content="Research Article" />
<meta name="citation_section" content="INTERVENTIONAL" />
<meta name="citation_author" content="S.C.H. Yu" />
<meta name="citation_author" content="T.W.H. Leung" />
<meta name="citation_author" content="K.T. Lee" />
<meta name="citation_author" content="J.W.Y. Hui" />
<meta name="citation_author" content="L.K.S. Wong" />
<meta name="twitter:title" content="Angioplasty and Stenting of Atherosclerotic Middle Cerebral Arteries with Wingspan: Evaluation of Clinical Outcome, Restenosis, and Procedure Outcome" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: MCA is a common location of intracranial stenosis. It is relatively more peripherally located and of a smaller caliber, and could therefore be a site technically more challenging and risky for angioplasty and stenting. The study aimed to evaluate the clinical outcome, restenosis rate, and procedural safety of Wingspan stent placement for atherosclerosis in the MCA compared with stenosis in other arteries.

MATERIALS AND METHODS: Patients who underwent Wingspan stent placement for symptomatic intracranial stenosis of ≥70% (or stenosis of ≥50% for recurrent ischemia despite medical therapy) were recruited prospectively and allocated into a study group (MCA stenosis, n = 35) and a control group (other stenosis, n = 25). Primary end points were the following: 1) all stroke or death rate at 1 year, and 2) significant in-stent restenosis rate at 1 year. Secondary end points were the following: 1) periprocedural complications within 24 hours, rate of TIA during the procedure, all stroke or death rate within 30 days; and 2) the inability to complete the procedure due to technical problems.

RESULTS: Results of study group versus the control group were the following: degree of stenosis, 78.4 ± 10.9% versus 72.5 ± 11.2% ( P value = .0456); diameter of stenosis, 0.6 ± 0.3 versus 1.0 ± 0.5 mm ( P = .0017); all stroke or death rate at 1 year, 14.3% versus 12% (OR = 1.22); in-stent restenosis rate at 1 year, 10% versus 10.5% (OR = 1.05); periprocedural complication rate at 24 hours, 2.9% versus 4% (OR = 0.70); TIA rate during the procedure, 8.6% versus 4% (OR = 2.25); all stroke or death rate at 30 days, 5.7% versus 12% (OR = 0.44); and technical failure rate, 2.9% versus 0%.

CONCLUSIONS: In this study, there were no significant differences in procedural safety, patient outcome, and restenosis rates of stent placement between the group with MCA stenosis and the group with stenoses located at other sites." />
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<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: MCA is a common location of intracranial stenosis. It is relatively more peripherally located and of a smaller caliber, and could therefore be a site technically more challenging and risky for angioplasty and stenting. The study aimed to evaluate the clinical outcome, restenosis rate, and procedural safety of Wingspan stent placement for atherosclerosis in the MCA compared with stenosis in other arteries.

MATERIALS AND METHODS: Patients who underwent Wingspan stent placement for symptomatic intracranial stenosis of ≥70% (or stenosis of ≥50% for recurrent ischemia despite medical therapy) were recruited prospectively and allocated into a study group (MCA stenosis, n = 35) and a control group (other stenosis, n = 25). Primary end points were the following: 1) all stroke or death rate at 1 year, and 2) significant in-stent restenosis rate at 1 year. Secondary end points were the following: 1) periprocedural complications within 24 hours, rate of TIA during the procedure, all stroke or death rate within 30 days; and 2) the inability to complete the procedure due to technical problems.

RESULTS: Results of study group versus the control group were the following: degree of stenosis, 78.4 ± 10.9% versus 72.5 ± 11.2% ( P value = .0456); diameter of stenosis, 0.6 ± 0.3 versus 1.0 ± 0.5 mm ( P = .0017); all stroke or death rate at 1 year, 14.3% versus 12% (OR = 1.22); in-stent restenosis rate at 1 year, 10% versus 10.5% (OR = 1.05); periprocedural complication rate at 24 hours, 2.9% versus 4% (OR = 0.70); TIA rate during the procedure, 8.6% versus 4% (OR = 2.25); all stroke or death rate at 30 days, 5.7% versus 12% (OR = 0.44); and technical failure rate, 2.9% versus 0%.

CONCLUSIONS: In this study, there were no significant differences in procedural safety, patient outcome, and restenosis rates of stent placement between the group with MCA stenosis and the group with stenoses located at other sites." />
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      <h1 class="highwire-cite-title" id="page-title">Angioplasty and Stenting of Atherosclerotic Middle Cerebral Arteries with Wingspan: Evaluation of Clinical Outcome, Restenosis, and Procedure Outcome</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">S.C.H. Yu</span>, <span class="highwire-citation-author" data-delta="1">T.W.H. Leung</span>, <span class="highwire-citation-author" data-delta="2">K.T. Lee</span>, <span class="highwire-citation-author" data-delta="3">J.W.Y. Hui</span> and <span class="highwire-citation-author" data-delta="4">L.K.S. Wong</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">March 2011,  </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A2363 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-49206--6680583888" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">S.C.H. Yu </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=S.C.H.%2BYu%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Yu%20S&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AS.C.H.%2BYu%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">T.W.H. Leung </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=T.W.H.%2BLeung%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Leung%20T&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AT.W.H.%2BLeung%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">K.T. Lee </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=K.T.%2BLee%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Lee%20K&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AK.T.%2BLee%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">J.W.Y. Hui </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.W.Y.%2BHui%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Hui%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AJ.W.Y.%2BHui%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">L.K.S. Wong </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=L.K.S.%2BWong%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Wong%20L&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AL.K.S.%2BWong%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div></div></div>  </div>

  
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<p id="p-1"><strong>BACKGROUND AND PURPOSE:</strong> MCA is a common location of intracranial stenosis. It is relatively more peripherally located and of a smaller caliber, and could therefore be a site technically more challenging and risky for angioplasty and stenting. The study aimed to evaluate the clinical outcome, restenosis rate, and procedural safety of Wingspan stent placement for atherosclerosis in the MCA compared with stenosis in other arteries.</p></div>
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<p id="p-2"><strong>MATERIALS AND METHODS:</strong> Patients who underwent Wingspan stent placement for symptomatic intracranial stenosis of ≥70% (or stenosis of ≥50% for recurrent ischemia despite medical therapy) were recruited prospectively and allocated into a study group (MCA stenosis, <em>n</em> = 35) and a control group (other stenosis, <em>n</em> = 25). Primary end points were the following: 1) all stroke or death rate at 1 year, and 2) significant in-stent restenosis rate at 1 year. Secondary end points were the following: 1) periprocedural complications within 24 hours, rate of TIA during the procedure, all stroke or death rate within 30 days; and 2) the inability to complete the procedure due to technical problems.</p></div>
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<p id="p-3"><strong>RESULTS:</strong> Results of study group versus the control group were the following: degree of stenosis, 78.4 ± 10.9% versus 72.5 ± 11.2% (<em>P</em> value = .0456); diameter of stenosis, 0.6 ± 0.3 versus 1.0 ± 0.5 mm (<em>P</em> = .0017); all stroke or death rate at 1 year, 14.3% versus 12% (OR = 1.22); in-stent restenosis rate at 1 year, 10% versus 10.5% (OR = 1.05); periprocedural complication rate at 24 hours, 2.9% versus 4% (OR = 0.70); TIA rate during the procedure, 8.6% versus 4% (OR = 2.25); all stroke or death rate at 30 days, 5.7% versus 12% (OR = 0.44); and technical failure rate, 2.9% versus 0%.</p></div>
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<p id="p-4"><strong>CONCLUSIONS:</strong> In this study, there were no significant differences in procedural safety, patient outcome, and restenosis rates of stent placement between the group with MCA stenosis and the group with stenoses located at other sites.</p>
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</div><div class="section fn-group" id="fn-group-1"><h2>Footnotes</h2><ul><li class="fn-abbr" id="fn-1">
<p id="p-5">
<dl id="def-list-1"><dt id="def-item-1">CI<span class="def-item-dt-sep"></span></dt><dd>confidence interval<span class="def-item-dd-sep"></span></dd><dt id="def-item-2">3DRA<span class="def-item-dt-sep"></span></dt><dd>3D rotational angiography<span class="def-item-dd-sep"></span></dd><dt id="def-item-3">DSA<span class="def-item-dt-sep"></span></dt><dd>digital-subtraction angiography<span class="def-item-dd-sep"></span></dd><dt id="def-item-4">MCA<span class="def-item-dt-sep"></span></dt><dd>middle cerebral artery<span class="def-item-dd-sep"></span></dd><dt id="def-item-5"><em>nFU</em><span class="def-item-dt-sep"></span></dt><dd>number of patients with follow-up DSA performed<span class="def-item-dd-sep"></span></dd><dt id="def-item-6">OR<span class="def-item-dt-sep"></span></dt><dd>odds ratio<span class="def-item-dd-sep"></span></dd><dt id="def-item-7">TIA<span class="def-item-dt-sep"></span></dt><dd>transient ischemic attack<span class="def-item-dd-sep"></span></dd><dt id="def-item-8">WASID<span class="def-item-dt-sep"></span></dt><dd>Warfarin Aspirin Symptomatic Intracranial Disease</dd></dl>
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</li></ul></div><ul class="copyright-statement"><li class="fn" id="copyright-statement-1">© 2011 American Society of Neuroradiology</li></ul><span class="highwire-journal-article-marker-end"></span></div><span class="related-urls"></span></div></div>  </div>

  
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