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<meta name="DC.Title" content="Changes in Integrity of Normal-Appearing White Matter in Patients with Moyamoya Disease: A Diffusion Tensor Imaging Study" />
<meta name="DC.Identifier" content="10.3174/ajnr.A2683" />
<meta name="DC.Date" content="2011-09-15" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: DTI is widely used for the evaluation of white matter integrity in various neurologic diseases. The purpose of this study was to investigate changes in white matter integrity by using DTI in NAWM of patients with MMD and to evaluate the correlation between diffusion and perfusion characteristics through an interhemispheric comparison.

MATERIALS AND METHODS: We retrospectively reviewed 20 primary MMD patients with asymmetric disease stage and 20 age-matched healthy controls. FACS and ADCCS values of bilateral centrum semiovale were measured by using region of interest analysis. Mean FACS and ADCCS were compared between patient and control groups by unpaired t test. Interhemispheric differences in FACS and ADCCS were assessed and compared between the H-TTPdelayed and the H-TTPshorter by using paired t test. AIs also were assessed to verify interhemispheric differences.

RESULTS: The patient group showed a significantly lower mean FACS and a higher mean ADCCS value than the control group. In the patient group, the H-TTPdelayed had a significantly lower FACS and higher ADCCS value than the H-TTPshorter. Both AIFA and AIADC were significantly higher in the patient compared with the control group.

CONCLUSIONS: DTI can describe subtle changes in white matter integrity in NAWM of patients with primary MMD that are not detected by conventional MR imaging. In addition, diffusion characteristics are well correlated with perfusion characteristics. We believe that DTI is a useful ancillary tool to evaluate patients with MMD." />
<meta name="DC.Contributor" content="H. Jeong" />
<meta name="DC.Contributor" content="J. Kim" />
<meta name="DC.Contributor" content="H.S. Choi" />
<meta name="DC.Contributor" content="E.S. Kim" />
<meta name="DC.Contributor" content="D.-S. Kim" />
<meta name="DC.Contributor" content="K.-W. Shim" />
<meta name="DC.Contributor" content="S.-K. Lee" />
<meta name="article:published_time" content="2011-09-14" />
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<meta name="citation_title" content="Changes in Integrity of Normal-Appearing White Matter in Patients with Moyamoya Disease: A Diffusion Tensor Imaging Study" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;DTI is widely used for the evaluation of white matter integrity in various neurologic diseases. The purpose of this study was to investigate changes in white matter integrity by using DTI in NAWM of patients with MMD and to evaluate the correlation between diffusion and perfusion characteristics through an interhemispheric comparison.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;We retrospectively reviewed 20 primary MMD patients with asymmetric disease stage and 20 age-matched healthy controls. FA&lt;sub&gt;CS&lt;/sub&gt; and ADC&lt;sub&gt;CS&lt;/sub&gt; values of bilateral centrum semiovale were measured by using region of interest analysis. Mean FA&lt;sub&gt;CS&lt;/sub&gt; and ADC&lt;sub&gt;CS&lt;/sub&gt; were compared between patient and control groups by unpaired &lt;i&gt;t&lt;/i&gt; test. Interhemispheric differences in FA&lt;sub&gt;CS&lt;/sub&gt; and ADC&lt;sub&gt;CS&lt;/sub&gt; were assessed and compared between the H-TTP&lt;sub&gt;delayed&lt;/sub&gt; and the H-TTP&lt;sub&gt;shorter&lt;/sub&gt; by using paired &lt;i&gt;t&lt;/i&gt; test. AIs also were assessed to verify interhemispheric differences.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;The patient group showed a significantly lower mean FA&lt;sub&gt;CS&lt;/sub&gt; and a higher mean ADC&lt;sub&gt;CS&lt;/sub&gt; value than the control group. In the patient group, the H-TTP&lt;sub&gt;delayed&lt;/sub&gt; had a significantly lower FA&lt;sub&gt;CS&lt;/sub&gt; and higher ADC&lt;sub&gt;CS&lt;/sub&gt; value than the H-TTP&lt;sub&gt;shorter&lt;/sub&gt;. Both AI&lt;sub&gt;FA&lt;/sub&gt; and AI&lt;sub&gt;ADC&lt;/sub&gt; were significantly higher in the patient compared with the control group.&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;DTI can describe subtle changes in white matter integrity in NAWM of patients with primary MMD that are not detected by conventional MR imaging. In addition, diffusion characteristics are well correlated with perfusion characteristics. We believe that DTI is a useful ancillary tool to evaluate patients with MMD.&lt;/p&gt;" />
<meta name="citation_journal_title" content="American Journal of Neuroradiology" />
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<meta name="citation_author" content="H. Jeong" />
<meta name="citation_author" content="J. Kim" />
<meta name="citation_author" content="H.S. Choi" />
<meta name="citation_author" content="E.S. Kim" />
<meta name="citation_author" content="D.-S. Kim" />
<meta name="citation_author" content="K.-W. Shim" />
<meta name="citation_author" content="S.-K. Lee" />
<meta name="twitter:title" content="Changes in Integrity of Normal-Appearing White Matter in Patients with Moyamoya Disease: A Diffusion Tensor Imaging Study" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: DTI is widely used for the evaluation of white matter integrity in various neurologic diseases. The purpose of this study was to investigate changes in white matter integrity by using DTI in NAWM of patients with MMD and to evaluate the correlation between diffusion and perfusion characteristics through an interhemispheric comparison.

MATERIALS AND METHODS: We retrospectively reviewed 20 primary MMD patients with asymmetric disease stage and 20 age-matched healthy controls. FACS and ADCCS values of bilateral centrum semiovale were measured by using region of interest analysis. Mean FACS and ADCCS were compared between patient and control groups by unpaired t test. Interhemispheric differences in FACS and ADCCS were assessed and compared between the H-TTPdelayed and the H-TTPshorter by using paired t test. AIs also were assessed to verify interhemispheric differences.

RESULTS: The patient group showed a significantly lower mean FACS and a higher mean ADCCS value than the control group. In the patient group, the H-TTPdelayed had a significantly lower FACS and higher ADCCS value than the H-TTPshorter. Both AIFA and AIADC were significantly higher in the patient compared with the control group.

CONCLUSIONS: DTI can describe subtle changes in white matter integrity in NAWM of patients with primary MMD that are not detected by conventional MR imaging. In addition, diffusion characteristics are well correlated with perfusion characteristics. We believe that DTI is a useful ancillary tool to evaluate patients with MMD." />
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<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: DTI is widely used for the evaluation of white matter integrity in various neurologic diseases. The purpose of this study was to investigate changes in white matter integrity by using DTI in NAWM of patients with MMD and to evaluate the correlation between diffusion and perfusion characteristics through an interhemispheric comparison.

MATERIALS AND METHODS: We retrospectively reviewed 20 primary MMD patients with asymmetric disease stage and 20 age-matched healthy controls. FACS and ADCCS values of bilateral centrum semiovale were measured by using region of interest analysis. Mean FACS and ADCCS were compared between patient and control groups by unpaired t test. Interhemispheric differences in FACS and ADCCS were assessed and compared between the H-TTPdelayed and the H-TTPshorter by using paired t test. AIs also were assessed to verify interhemispheric differences.

RESULTS: The patient group showed a significantly lower mean FACS and a higher mean ADCCS value than the control group. In the patient group, the H-TTPdelayed had a significantly lower FACS and higher ADCCS value than the H-TTPshorter. Both AIFA and AIADC were significantly higher in the patient compared with the control group.

CONCLUSIONS: DTI can describe subtle changes in white matter integrity in NAWM of patients with primary MMD that are not detected by conventional MR imaging. In addition, diffusion characteristics are well correlated with perfusion characteristics. We believe that DTI is a useful ancillary tool to evaluate patients with MMD." />
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      <h1 class="highwire-cite-title" id="page-title">Changes in Integrity of Normal-Appearing White Matter in Patients with Moyamoya Disease: A Diffusion Tensor Imaging Study</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">H. Jeong</span>, <span class="highwire-citation-author" data-delta="1">J. Kim</span>, <span class="highwire-citation-author" data-delta="2">H.S. Choi</span>, <span class="highwire-citation-author" data-delta="3">E.S. Kim</span>, <span class="highwire-citation-author" data-delta="4">D.-S. Kim</span>, <span class="highwire-citation-author" data-delta="5">K.-W. Shim</span> and <span class="highwire-citation-author" data-delta="6">S.-K. Lee</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">September 2011,  </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A2683 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-49337--61991585513" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">H. Jeong </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=H.%2BJeong%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Jeong%20H&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AH.%2BJeong%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">J. 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<p id="p-1"><strong>BACKGROUND AND PURPOSE:</strong> DTI is widely used for the evaluation of white matter integrity in various neurologic diseases. The purpose of this study was to investigate changes in white matter integrity by using DTI in NAWM of patients with MMD and to evaluate the correlation between diffusion and perfusion characteristics through an interhemispheric comparison.</p></div>
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<p id="p-2"><strong>MATERIALS AND METHODS:</strong> We retrospectively reviewed 20 primary MMD patients with asymmetric disease stage and 20 age-matched healthy controls. FA<sub>CS</sub> and ADC<sub>CS</sub> values of bilateral centrum semiovale were measured by using region of interest analysis. Mean FA<sub>CS</sub> and ADC<sub>CS</sub> were compared between patient and control groups by unpaired <em>t</em> test. Interhemispheric differences in FA<sub>CS</sub> and ADC<sub>CS</sub> were assessed and compared between the H-TTP<sub>delayed</sub> and the H-TTP<sub>shorter</sub> by using paired <em>t</em> test. AIs also were assessed to verify interhemispheric differences.</p></div>
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<p id="p-3"><strong>RESULTS:</strong> The patient group showed a significantly lower mean FA<sub>CS</sub> and a higher mean ADC<sub>CS</sub> value than the control group. In the patient group, the H-TTP<sub>delayed</sub> had a significantly lower FA<sub>CS</sub> and higher ADC<sub>CS</sub> value than the H-TTP<sub>shorter</sub>. Both AI<sub>FA</sub> and AI<sub>ADC</sub> were significantly higher in the patient compared with the control group.</p></div>
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<p id="p-4"><strong>CONCLUSIONS:</strong> DTI can describe subtle changes in white matter integrity in NAWM of patients with primary MMD that are not detected by conventional MR imaging. In addition, diffusion characteristics are well correlated with perfusion characteristics. We believe that DTI is a useful ancillary tool to evaluate patients with MMD.</p>
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</div><div class="section fn-group" id="fn-group-1"><h2>Footnotes</h2><ul><li class="fn-abbr" id="fn-1">
<p id="p-5">
<dl id="def-list-1"><dt id="def-item-1">ADC<sub>CS</sub><span class="def-item-dt-sep"></span></dt><dd>apparent diffusion coefficient in centrum semiovale<span class="def-item-dd-sep"></span></dd><dt id="def-item-2">AI<span class="def-item-dt-sep"></span></dt><dd>asymmetric index<span class="def-item-dd-sep"></span></dd><dt id="def-item-3">FA<sub>CS</sub><span class="def-item-dt-sep"></span></dt><dd>fractional anisotropy in centrum semiovale<span class="def-item-dd-sep"></span></dd><dt id="def-item-4">H-TTP<sub>delayed</sub><span class="def-item-dt-sep"></span></dt><dd>hemisphere with more delayed time-to-peak<span class="def-item-dd-sep"></span></dd><dt id="def-item-5">H-TTP<sub>shorter</sub><span class="def-item-dt-sep"></span></dt><dd>contralateral hemisphere of H-TTP<sub>delayed</sub><span class="def-item-dd-sep"></span></dd><dt id="def-item-6">MMD<span class="def-item-dt-sep"></span></dt><dd>Moyamoya disease<span class="def-item-dd-sep"></span></dd><dt id="def-item-7">NAWM<span class="def-item-dt-sep"></span></dt><dd>normal-appearing white matter<span class="def-item-dd-sep"></span></dd><dt id="def-item-8">PWI<span class="def-item-dt-sep"></span></dt><dd>perfusion-weighted MR imaging<span class="def-item-dd-sep"></span></dd><dt id="def-item-9">rCBV<span class="def-item-dt-sep"></span></dt><dd>relative cerebral blood volume</dd></dl>
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