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<meta name="DC.Title" content="Association of CT Perfusion Parameters with Hemorrhagic Transformation in Acute Ischemic Stroke" />
<meta name="DC.Identifier" content="10.3174/ajnr.A3502" />
<meta name="DC.Date" content="2013-04-18" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Prediction of hemorrhagic transformation in acute ischemic stroke could help determine treatment and prognostication. With increasing numbers of patients with acute ischemic stroke undergoing multimodal CT imaging, we examined whether CT perfusion could predict hemorrhagic transformation in acute ischemic stroke.

MATERIALS AND METHODS: Patients with acute ischemic stroke who underwent CTP scanning within 12 hours of symptom onset were examined. Patients with and without hemorrhagic transformation were defined as cases and controls, respectively, and were matched as to IV rtPA administration and presentation NIHSS score (± 2). Relative mean transit time, relative CBF, and relative CBV values were calculated from CTP maps and normalized to the contralateral side. Receiver operating characteristic analysis curves were created, and threshold values for significant CTP parameters were obtained to predict hemorrhagic transformation.

RESULTS: Of 83 patients with acute ischemic stroke, 16 developed hemorrhagic transformation (19.28%). By matching, 38 controls were found for only 14 patients with hemorrhagic transformation. Among the matched patients with hemorrhagic transformation, 13 developed hemorrhagic infarction (6 hemorrhagic infarction 1 and 7 hemorrhagic infarction 2) and 1 developed parenchymal hematoma 2. There was no significant difference between cases and controls with respect to age, sex, time to presentation from symptom onset, and comorbidities. Cases had significantly lower median rCBV (8% lower) compared with controls (11% higher) ( P = .009; odds ratio, 1.14 for a 0.1-U decrease in rCBV). There was no difference in median total volume of ischemia, rMTT, and rCBF among cases and controls. The area under the receiver operating characteristic was computed to be 0.83 (standard error, 0.08), with a cutoff point for rCBV of 1.09.

CONCLUSIONS: Of the examined CTP parameters, only lower rCBV was found to be significantly associated with a relatively higher chance of hemorrhagic transformation.

### Abbreviations

AIS
:   acute ischemic stroke
rCBF
:   relative cerebral blood flow
rCBV
:   relative cerebral blood volume
HI
:   hemorrhagic infarction
HT
:   hemorrhagic transformation
IQR
:   interquartile range
rMTT
:   relative mean transit time
ROC
:   receiver operating characteristic analysis
PH
:   parenchymal hematoma" />
<meta name="DC.Contributor" content="A.R. Jain" />
<meta name="DC.Contributor" content="M. Jain" />
<meta name="DC.Contributor" content="A.R. Kanthala" />
<meta name="DC.Contributor" content="D. Damania" />
<meta name="DC.Contributor" content="L.G. Stead" />
<meta name="DC.Contributor" content="H.Z. Wang" />
<meta name="DC.Contributor" content="B.S. Jahromi" />
<meta name="article:published_time" content="2013-04-18" />
<meta name="article:section" content="BRAIN" />
<meta name="citation_title" content="Association of CT Perfusion Parameters with Hemorrhagic Transformation in Acute Ischemic Stroke" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;Prediction of hemorrhagic transformation in acute ischemic stroke could help determine treatment and prognostication. With increasing numbers of patients with acute ischemic stroke undergoing multimodal CT imaging, we examined whether CT perfusion could predict hemorrhagic transformation in acute ischemic stroke.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;Patients with acute ischemic stroke who underwent CTP scanning within 12 hours of symptom onset were examined. Patients with and without hemorrhagic transformation were defined as cases and controls, respectively, and were matched as to IV rtPA administration and presentation NIHSS score (± 2). Relative mean transit time, relative CBF, and relative CBV values were calculated from CTP maps and normalized to the contralateral side. Receiver operating characteristic analysis curves were created, and threshold values for significant CTP parameters were obtained to predict hemorrhagic transformation.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;Of 83 patients with acute ischemic stroke, 16 developed hemorrhagic transformation (19.28%). By matching, 38 controls were found for only 14 patients with hemorrhagic transformation. Among the matched patients with hemorrhagic transformation, 13 developed hemorrhagic infarction (6 hemorrhagic infarction 1 and 7 hemorrhagic infarction 2) and 1 developed parenchymal hematoma 2. There was no significant difference between cases and controls with respect to age, sex, time to presentation from symptom onset, and comorbidities. Cases had significantly lower median rCBV (8% lower) compared with controls (11% higher) (&lt;i&gt;P&lt;/i&gt; = .009; odds ratio, 1.14 for a 0.1-U decrease in rCBV). There was no difference in median total volume of ischemia, rMTT, and rCBF among cases and controls. The area under the receiver operating characteristic was computed to be 0.83 (standard error, 0.08), with a cutoff point for rCBV of 1.09.&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;Of the examined CTP parameters, only lower rCBV was found to be significantly associated with a relatively higher chance of hemorrhagic transformation.&lt;/p&gt;" />
<meta name="citation_journal_title" content="American Journal of Neuroradiology" />
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<meta name="citation_publication_date" content="2013/04/18" />
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<meta name="citation_author" content="A.R. Jain" />
<meta name="citation_author_institution" content="From the Departments of Neurosurgery (A.R.J., M.J., A.R.K., D.D., B.S.J.) and Imaging Sciences (H.Z.W.), University of Rochester Medical Center, Rochester, New York; and Departments of Emergency Medicine and Neurological Surgery (LG.S.), University of Florida College of Medicine, Gainesville, Florida." />
<meta name="citation_author" content="M. Jain" />
<meta name="citation_author_institution" content="From the Departments of Neurosurgery (A.R.J., M.J., A.R.K., D.D., B.S.J.) and Imaging Sciences (H.Z.W.), University of Rochester Medical Center, Rochester, New York; and Departments of Emergency Medicine and Neurological Surgery (LG.S.), University of Florida College of Medicine, Gainesville, Florida." />
<meta name="citation_author" content="A.R. Kanthala" />
<meta name="citation_author_institution" content="From the Departments of Neurosurgery (A.R.J., M.J., A.R.K., D.D., B.S.J.) and Imaging Sciences (H.Z.W.), University of Rochester Medical Center, Rochester, New York; and Departments of Emergency Medicine and Neurological Surgery (LG.S.), University of Florida College of Medicine, Gainesville, Florida." />
<meta name="citation_author" content="D. Damania" />
<meta name="citation_author_institution" content="From the Departments of Neurosurgery (A.R.J., M.J., A.R.K., D.D., B.S.J.) and Imaging Sciences (H.Z.W.), University of Rochester Medical Center, Rochester, New York; and Departments of Emergency Medicine and Neurological Surgery (LG.S.), University of Florida College of Medicine, Gainesville, Florida." />
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<meta name="citation_author_institution" content="From the Departments of Neurosurgery (A.R.J., M.J., A.R.K., D.D., B.S.J.) and Imaging Sciences (H.Z.W.), University of Rochester Medical Center, Rochester, New York; and Departments of Emergency Medicine and Neurological Surgery (LG.S.), University of Florida College of Medicine, Gainesville, Florida." />
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<meta name="twitter:title" content="Association of CT Perfusion Parameters with Hemorrhagic Transformation in Acute Ischemic Stroke" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Prediction of hemorrhagic transformation in acute ischemic stroke could help determine treatment and prognostication. With increasing numbers of patients with acute ischemic stroke undergoing multimodal CT imaging, we examined whether CT perfusion could predict hemorrhagic transformation in acute ischemic stroke.

MATERIALS AND METHODS: Patients with acute ischemic stroke who underwent CTP scanning within 12 hours of symptom onset were examined. Patients with and without hemorrhagic transformation were defined as cases and controls, respectively, and were matched as to IV rtPA administration and presentation NIHSS score (± 2). Relative mean transit time, relative CBF, and relative CBV values were calculated from CTP maps and normalized to the contralateral side. Receiver operating characteristic analysis curves were created, and threshold values for significant CTP parameters were obtained to predict hemorrhagic transformation.

RESULTS: Of 83 patients with acute ischemic stroke, 16 developed hemorrhagic transformation (19.28%). By matching, 38 controls were found for only 14 patients with hemorrhagic transformation. Among the matched patients with hemorrhagic transformation, 13 developed hemorrhagic infarction (6 hemorrhagic infarction 1 and 7 hemorrhagic infarction 2) and 1 developed parenchymal hematoma 2. There was no significant difference between cases and controls with respect to age, sex, time to presentation from symptom onset, and comorbidities. Cases had significantly lower median rCBV (8% lower) compared with controls (11% higher) ( P = .009; odds ratio, 1.14 for a 0.1-U decrease in rCBV). There was no difference in median total volume of ischemia, rMTT, and rCBF among cases and controls. The area under the receiver operating characteristic was computed to be 0.83 (standard error, 0.08), with a cutoff point for rCBV of 1.09.

CONCLUSIONS: Of the examined CTP parameters, only lower rCBV was found to be significantly associated with a relatively higher chance of hemorrhagic transformation.

### Abbreviations

AIS
:   acute ischemic stroke
rCBF
:   relative cerebral blood flow
rCBV
:   relative cerebral blood volume
HI
:   hemorrhagic infarction
HT
:   hemorrhagic transformation
IQR
:   interquartile range
rMTT
:   relative mean transit time
ROC
:   receiver operating characteristic analysis
PH
:   parenchymal hematoma" />
<meta name="og-title" property="og:title" content="Association of CT Perfusion Parameters with Hemorrhagic Transformation in Acute Ischemic Stroke" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/early/2013/04/18/ajnr.A3502" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Prediction of hemorrhagic transformation in acute ischemic stroke could help determine treatment and prognostication. With increasing numbers of patients with acute ischemic stroke undergoing multimodal CT imaging, we examined whether CT perfusion could predict hemorrhagic transformation in acute ischemic stroke.

MATERIALS AND METHODS: Patients with acute ischemic stroke who underwent CTP scanning within 12 hours of symptom onset were examined. Patients with and without hemorrhagic transformation were defined as cases and controls, respectively, and were matched as to IV rtPA administration and presentation NIHSS score (± 2). Relative mean transit time, relative CBF, and relative CBV values were calculated from CTP maps and normalized to the contralateral side. Receiver operating characteristic analysis curves were created, and threshold values for significant CTP parameters were obtained to predict hemorrhagic transformation.

RESULTS: Of 83 patients with acute ischemic stroke, 16 developed hemorrhagic transformation (19.28%). By matching, 38 controls were found for only 14 patients with hemorrhagic transformation. Among the matched patients with hemorrhagic transformation, 13 developed hemorrhagic infarction (6 hemorrhagic infarction 1 and 7 hemorrhagic infarction 2) and 1 developed parenchymal hematoma 2. There was no significant difference between cases and controls with respect to age, sex, time to presentation from symptom onset, and comorbidities. Cases had significantly lower median rCBV (8% lower) compared with controls (11% higher) ( P = .009; odds ratio, 1.14 for a 0.1-U decrease in rCBV). There was no difference in median total volume of ischemia, rMTT, and rCBF among cases and controls. The area under the receiver operating characteristic was computed to be 0.83 (standard error, 0.08), with a cutoff point for rCBV of 1.09.

CONCLUSIONS: Of the examined CTP parameters, only lower rCBV was found to be significantly associated with a relatively higher chance of hemorrhagic transformation.

### Abbreviations

AIS
:   acute ischemic stroke
rCBF
:   relative cerebral blood flow
rCBV
:   relative cerebral blood volume
HI
:   hemorrhagic infarction
HT
:   hemorrhagic transformation
IQR
:   interquartile range
rMTT
:   relative mean transit time
ROC
:   receiver operating characteristic analysis
PH
:   parenchymal hematoma" />
<meta name="og-type" property="og:type" content="article" />
<meta name="og-image" property="og:image" content="" />
<link rel="shortlink" href="/node/50199" />
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node50199--5" data-node-nid="50199" id="top-node-50199--61770133156" data-pisa="ajnr;ajnr.A3502v1" data-pisa-master="ajnr;ajnr.A3502" data-apath="/ajnr/early/2013/04/18/ajnr.A3502.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">A.R. Jain</span>, <span class="highwire-citation-author" data-delta="1">M. Jain</span>, <span class="highwire-citation-author" data-delta="2">A.R. Kanthala</span>, <span class="highwire-citation-author" data-delta="3">D. Damania</span>, <span class="highwire-citation-author" data-delta="4">L.G. Stead</span>, <span class="highwire-citation-author" data-delta="5">H.Z. Wang</span> and <span class="highwire-citation-author" data-delta="6">B.S. Jahromi</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">April 2013,  </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A3502 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-50199--61770133156" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">A.R. Jain </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'>From the Departments of Neurosurgery (A.R.J., M.J., A.R.K., D.D., B.S.J.) and Imaging Sciences (H.Z.W.), University of Rochester Medical Center, Rochester, New York; and Departments of Emergency Medicine and Neurological Surgery (LG.S.), University of Florida College of Medicine, Gainesville, Florida.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.R.%2BJain%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Jain%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AA.R.%2BJain%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">M. Jain </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'>From the Departments of Neurosurgery (A.R.J., M.J., A.R.K., D.D., B.S.J.) and Imaging Sciences (H.Z.W.), University of Rochester Medical Center, Rochester, New York; and Departments of Emergency Medicine and Neurological Surgery (LG.S.), University of Florida College of Medicine, Gainesville, Florida.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.%2BJain%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Jain%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AM.%2BJain%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">A.R. Kanthala </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'>From the Departments of Neurosurgery (A.R.J., M.J., A.R.K., D.D., B.S.J.) and Imaging Sciences (H.Z.W.), University of Rochester Medical Center, Rochester, New York; and Departments of Emergency Medicine and Neurological Surgery (LG.S.), University of Florida College of Medicine, Gainesville, Florida.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.R.%2BKanthala%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Kanthala%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AA.R.%2BKanthala%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">D. Damania </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'>From the Departments of Neurosurgery (A.R.J., M.J., A.R.K., D.D., B.S.J.) and Imaging Sciences (H.Z.W.), University of Rochester Medical Center, Rochester, New York; and Departments of Emergency Medicine and Neurological Surgery (LG.S.), University of Florida College of Medicine, Gainesville, Florida.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=D.%2BDamania%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Damania%20D&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AD.%2BDamania%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">L.G. Stead </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'>From the Departments of Neurosurgery (A.R.J., M.J., A.R.K., D.D., B.S.J.) and Imaging Sciences (H.Z.W.), University of Rochester Medical Center, Rochester, New York; and Departments of Emergency Medicine and Neurological Surgery (LG.S.), University of Florida College of Medicine, Gainesville, Florida.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=L.G.%2BStead%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Stead%20L&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AL.G.%2BStead%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-5"><div class="author-tooltip-name">H.Z. Wang </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'>From the Departments of Neurosurgery (A.R.J., M.J., A.R.K., D.D., B.S.J.) and Imaging Sciences (H.Z.W.), University of Rochester Medical Center, Rochester, New York; and Departments of Emergency Medicine and Neurological Surgery (LG.S.), University of Florida College of Medicine, Gainesville, Florida.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=H.Z.%2BWang%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Wang%20H&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AH.Z.%2BWang%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-6"><div class="author-tooltip-name">B.S. 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<p id="p-2"><strong>BACKGROUND AND PURPOSE:</strong> Prediction of hemorrhagic transformation in acute ischemic stroke could help determine treatment and prognostication. With increasing numbers of patients with acute ischemic stroke undergoing multimodal CT imaging, we examined whether CT perfusion could predict hemorrhagic transformation in acute ischemic stroke.</p>
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<p id="p-3"><strong>MATERIALS AND METHODS:</strong> Patients with acute ischemic stroke who underwent CTP scanning within 12 hours of symptom onset were examined. Patients with and without hemorrhagic transformation were defined as cases and controls, respectively, and were matched as to IV rtPA administration and presentation NIHSS score (± 2). Relative mean transit time, relative CBF, and relative CBV values were calculated from CTP maps and normalized to the contralateral side. Receiver operating characteristic analysis curves were created, and threshold values for significant CTP parameters were obtained to predict hemorrhagic transformation.</p>
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<p id="p-4"><strong>RESULTS:</strong> Of 83 patients with acute ischemic stroke, 16 developed hemorrhagic transformation (19.28%). By matching, 38 controls were found for only 14 patients with hemorrhagic transformation. Among the matched patients with hemorrhagic transformation, 13 developed hemorrhagic infarction (6 hemorrhagic infarction 1 and 7 hemorrhagic infarction 2) and 1 developed parenchymal hematoma 2. There was no significant difference between cases and controls with respect to age, sex, time to presentation from symptom onset, and comorbidities. Cases had significantly lower median rCBV (8% lower) compared with controls (11% higher) (<em>P</em> = .009; odds ratio, 1.14 for a 0.1-U decrease in rCBV). There was no difference in median total volume of ischemia, rMTT, and rCBF among cases and controls. The area under the receiver operating characteristic was computed to be 0.83 (standard error, 0.08), with a cutoff point for rCBV of 1.09.</p>
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<p id="p-5"><strong>CONCLUSIONS:</strong> Of the examined CTP parameters, only lower rCBV was found to be significantly associated with a relatively higher chance of hemorrhagic transformation.</p>
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</div><div class="section glossary" id="glossary-1">
<h3>Abbreviations</h3>
<dl id="def-list-1"><dt id="def-item-1">AIS<span class="def-item-dt-sep"></span></dt><dd>acute ischemic stroke<span class="def-item-dd-sep"></span></dd><dt id="def-item-2">rCBF<span class="def-item-dt-sep"></span></dt><dd>relative cerebral blood flow<span class="def-item-dd-sep"></span></dd><dt id="def-item-3">rCBV<span class="def-item-dt-sep"></span></dt><dd>relative cerebral blood volume<span class="def-item-dd-sep"></span></dd><dt id="def-item-4">HI<span class="def-item-dt-sep"></span></dt><dd>hemorrhagic infarction<span class="def-item-dd-sep"></span></dd><dt id="def-item-5">HT<span class="def-item-dt-sep"></span></dt><dd>hemorrhagic transformation<span class="def-item-dd-sep"></span></dd><dt id="def-item-6">IQR<span class="def-item-dt-sep"></span></dt><dd>interquartile range<span class="def-item-dd-sep"></span></dd><dt id="def-item-7">rMTT<span class="def-item-dt-sep"></span></dt><dd>relative mean transit time<span class="def-item-dd-sep"></span></dd><dt id="def-item-8">ROC<span class="def-item-dt-sep"></span></dt><dd>receiver operating characteristic analysis<span class="def-item-dd-sep"></span></dd><dt id="def-item-9">PH<span class="def-item-dt-sep"></span></dt><dd>parenchymal hematoma</dd></dl>
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      <div class="highwire-cite-title">Association of CT Perfusion Parameters with Hemorrhagic Transformation in Acute Ischemic Stroke</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">A.R.</span> <span class="nlm-surname">Jain</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Jain</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">A.R.</span> <span class="nlm-surname">Kanthala</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">D.</span> <span class="nlm-surname">Damania</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">L.G.</span> <span class="nlm-surname">Stead</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">H.Z.</span> <span class="nlm-surname">Wang</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">B.S.</span> <span class="nlm-surname">Jahromi</span></span></span></div>
  
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">A.R.</span> <span class="nlm-surname">Jain</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Jain</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">A.R.</span> <span class="nlm-surname">Kanthala</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">D.</span> <span class="nlm-surname">Damania</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">L.G.</span> <span class="nlm-surname">Stead</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">H.Z.</span> <span class="nlm-surname">Wang</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">B.S.</span> <span class="nlm-surname">Jahromi</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-oa-ind highwire-cite-metadata"><i class="highwire-oa-indicator"></i> </span><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Apr 2013, </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A3502 </span></div>
  
  
  
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