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<meta name="DC.Title" content="A clinical and neuropathologic study of silk suture as an embolic agent for brain arteriovenous malformations." />
<meta name="DC.Date" content="1994-02-01" />
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<meta name="DC.Description" content="PURPOSE To evaluate the safety and efficacy of silk suture as an agent for preoperative embolization of cerebral arteriovenous malformations.

METHODS Clinical and histopathologic results were analyzed in six patients who underwent embolization of cerebral arteriovenous malformations using silk suture in combination with other agents.

RESULTS Three of the patients treated with silk hemorrhaged after embolization, and two of these patients died. Neuropathologic analysis of four patients showed acute perivascular inflammation, sometimes quite severe.

CONCLUSIONS The inflammatory response to silk may explain its effectiveness in producing vascular occlusion. However, a fulminate vasculitis theoretically can predispose to delayed hemorrhage. Other problems with silk include the pressure required to inject the agent and the inability to determine the final site of deposition of the silk. Although other embolic agents may share some of these potential difficulties, we feel that the disadvantages outweigh the advantages of silk as an embolic agent." />
<meta name="DC.Contributor" content="J P Deveikis" />
<meta name="DC.Contributor" content="H J Manz" />
<meta name="DC.Contributor" content="A J Luessenhop" />
<meta name="DC.Contributor" content="A J Caputy" />
<meta name="DC.Contributor" content="A I Kobrine" />
<meta name="DC.Contributor" content="D Schellinger" />
<meta name="DC.Contributor" content="N Patronas" />
<meta name="article:published_time" content="1994-02-01" />
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&lt;p&gt;To evaluate the safety and efficacy of silk suture as an agent for preoperative embolization of cerebral arteriovenous malformations.&lt;/p&gt;&lt;h3&gt;METHODS&lt;/h3&gt;
&lt;p&gt;Clinical and histopathologic results were analyzed in six patients who underwent embolization of cerebral arteriovenous malformations using silk suture in combination with other agents.&lt;/p&gt;&lt;h3&gt;RESULTS&lt;/h3&gt;
&lt;p&gt;Three of the patients treated with silk hemorrhaged after embolization, and two of these patients died. Neuropathologic analysis of four patients showed acute perivascular inflammation, sometimes quite severe.&lt;/p&gt;&lt;h3&gt;CONCLUSIONS&lt;/h3&gt;
&lt;p&gt;The inflammatory response to silk may explain its effectiveness in producing vascular occlusion. However, a fulminate vasculitis theoretically can predispose to delayed hemorrhage. Other problems with silk include the pressure required to inject the agent and the inability to determine the final site of deposition of the silk. Although other embolic agents may share some of these potential difficulties, we feel that the disadvantages outweigh the advantages of silk as an embolic agent.&lt;/p&gt;" />
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<meta name="citation_author" content="J P Deveikis" />
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<meta name="citation_author" content="A J Caputy" />
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<meta name="citation_author" content="A I Kobrine" />
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<meta name="twitter:description" content="PURPOSE To evaluate the safety and efficacy of silk suture as an agent for preoperative embolization of cerebral arteriovenous malformations.

METHODS Clinical and histopathologic results were analyzed in six patients who underwent embolization of cerebral arteriovenous malformations using silk suture in combination with other agents.

RESULTS Three of the patients treated with silk hemorrhaged after embolization, and two of these patients died. Neuropathologic analysis of four patients showed acute perivascular inflammation, sometimes quite severe.

CONCLUSIONS The inflammatory response to silk may explain its effectiveness in producing vascular occlusion. However, a fulminate vasculitis theoretically can predispose to delayed hemorrhage. Other problems with silk include the pressure required to inject the agent and the inability to determine the final site of deposition of the silk. Although other embolic agents may share some of these potential difficulties, we feel that the disadvantages outweigh the advantages of silk as an embolic agent." />
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<meta name="og-description" property="og:description" content="PURPOSE To evaluate the safety and efficacy of silk suture as an agent for preoperative embolization of cerebral arteriovenous malformations.

METHODS Clinical and histopathologic results were analyzed in six patients who underwent embolization of cerebral arteriovenous malformations using silk suture in combination with other agents.

RESULTS Three of the patients treated with silk hemorrhaged after embolization, and two of these patients died. Neuropathologic analysis of four patients showed acute perivascular inflammation, sometimes quite severe.

CONCLUSIONS The inflammatory response to silk may explain its effectiveness in producing vascular occlusion. However, a fulminate vasculitis theoretically can predispose to delayed hemorrhage. Other problems with silk include the pressure required to inject the agent and the inability to determine the final site of deposition of the silk. Although other embolic agents may share some of these potential difficulties, we feel that the disadvantages outweigh the advantages of silk as an embolic agent." />
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      <h1 class="highwire-cite-title" id="page-title">A clinical and neuropathologic study of silk suture as an embolic agent for brain arteriovenous malformations.</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">J P Deveikis</span>, <span class="highwire-citation-author" data-delta="1">H J Manz</span>, <span class="highwire-citation-author" data-delta="2">A J Luessenhop</span>, <span class="highwire-citation-author" data-delta="3">A J Caputy</span>, <span class="highwire-citation-author" data-delta="4">A I Kobrine</span>, <span class="highwire-citation-author" data-delta="5">D Schellinger</span> and <span class="highwire-citation-author" data-delta="6">N Patronas</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">February 1994,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">15 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(2) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">263-271; </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-5948--61286633883" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">J P Deveikis </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'>Department of Radiology (Neuroradiology) Georgetown University Hospital, Washington, DC.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J%2BP%2BDeveikis%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Deveikis%20JP&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a 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          <p id="p-1"><strong>PURPOSE</strong> To evaluate the safety and efficacy of silk suture as an agent for preoperative embolization of cerebral arteriovenous malformations.</p>
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          <p id="p-2"><strong>METHODS</strong> Clinical and histopathologic results were analyzed in six patients who underwent embolization of cerebral arteriovenous malformations using silk suture in combination with other agents.</p>
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          <p id="p-3"><strong>RESULTS</strong> Three of the patients treated with silk hemorrhaged after embolization, and two of these patients died. Neuropathologic analysis of four patients showed acute perivascular inflammation, sometimes quite severe.</p>
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          <p id="p-4"><strong>CONCLUSIONS</strong> The inflammatory response to silk may explain its effectiveness in producing vascular occlusion. However, a fulminate vasculitis theoretically can predispose to delayed hemorrhage. Other problems with silk include the pressure required to inject the agent and the inability to determine the final site of deposition of the silk. Although other embolic agents may share some of these potential difficulties, we feel that the disadvantages outweigh the advantages of silk as an embolic agent.</p>
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      <div class="highwire-cite-title">A clinical and neuropathologic study of silk suture as an embolic agent for brain arteriovenous malformations.</div>  
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      <div class="highwire-cite-title">A clinical and neuropathologic study of silk suture as an embolic agent for brain arteriovenous malformations.</div>  
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