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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">N. Arai</span> and <span class="highwire-citation-author" data-delta="1">H. Kan</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">April 2020,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">41 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(4) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">E21; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A6473 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-74408--6228615176" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">N. Arai </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>Department of RadiologyNagoya City University HospitalNagoya, Japan</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=N.%2BArai%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Arai%20N&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AN.%2BArai%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-1486-0744" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for N. Arai</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">H. Kan </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Radiological and Medical Laboratory SciencesNagoya University Graduate School of MedicineNagoya, Japan</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=H.%2BKan%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Kan%20H&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AH.%2BKan%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="https://orcid.org/0000-0002-5688-2685" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for H. Kan</a></li></ul></div></div></div>  </div>

  
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    <div data-panels-ajax-tab-preloaded="jnl_ajnr_tab_art" id="panels-ajax-tab-container-highwire_article_tabs" class="panels-ajax-tab-container"><div class="panels-ajax-tab-loading" style ="display:none"><img class="loading" src="http://ajnr-stage2.stage.highwire.org/sites/all/modules/contrib/panels_ajax_tab/images/loading.gif" alt="Loading" title="Loading" /></div><div class="panels-ajax-tab-wrap-jnl_ajnr_tab_art"><div class="panel-display panel-1col clearfix" >
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    <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" data-highwire-cite-ref-tooltip-instance="highwire_reflinks_tooltip" class="content-block-markup" xmlns:xhtml="http://www.w3.org/1999/xhtml"><div class="article fulltext-view "><span class="highwire-journal-article-marker-start"></span><p id="p-1">We greatly appreciate the interest of Dr Kim in our work and his knowledgeable comments regarding our article that was recently published in the <em>American Journal of Neuroradiology</em>.<sup><a id="xref-ref-1-1" class="xref-bibr" href="#ref-1">1</a></sup> He has highlighted several important points that we will address in this response.</p><p id="p-2">The first implication on the meaning of the asymmetry of the cell cluster, regardless of whether nigrosome-1 is healthy, is important and should be clarified. Our study discussed the visualization of nigrosome-1 asymmetry using clinical MR imaging.<sup><a id="xref-ref-2-1" class="xref-bibr" href="#ref-2">2</a></sup> We believe that our views are shared by most authors with considerable experience in clinical MR imaging examinations.</p><p id="p-3">Dr Kim suggests that the magic angle effect appears hyperintense because of sequences using a short TE. It is rightfully pointed out that this is an MR imaging phenomenon that is often discussed with regard to fiber structures in orthopedic and neurologic cases, among others. However, we discuss the magic angle that presents universally in the B<sub>0</sub> direction. In particular, the change in the magnitude of the interaction becomes a conspicuous interference along the magic angle because of the dipole–dipole interaction.<sup><a id="xref-ref-3-1" class="xref-bibr" href="#ref-3">3</a>,<a id="xref-ref-4-1" class="xref-bibr" href="#ref-4">4</a></sup> This change affects the MR signal intensity around the boundary between the susceptibility of different tissues. As mentioned earlier in the Discussion section, quantitative susceptibility mapping was performed to support the magic angle. Our response to the third question is the same as previously mentioned. It is not the relation to the fiber array dependency.</p><p id="p-4">Fig 5<em>A</em> reveals the quantitative susceptibility mapping, which was not used to describe the nigrosome-1 regions. Quantitative susceptibility mapping eliminates the magic angle effect because of the deconvolution of phase data with a dipole kernel. The imaging techniques that make nigrosome-1 hyperintense (ie, the swallow tail sign) affect the magic angle; therefore, there are differences in image contrasts.</p><p id="p-5">Finally, the volume of nigrosome-1 is 7 slices’ worth that was reported in a previous study by Dr Kim (ie, 0.5 × 0.5 × 1.0 mm<sup>3</sup>).<sup><a id="xref-ref-5-1" class="xref-bibr" href="#ref-5">5</a></sup> The partial volume effect cannot be assumed because our voxel size parameter (ie, 0.63 × 0.63 × 1.5 mm<sup>3</sup>) wasslightly larger than that reported by Dr Kim. To be sure, we performed high-resolution (ie, 0.5 × 0.5 × 0.9 mm<sup>3</sup>) imaging (<a id="xref-fig-1-1" class="xref-fig" href="#F1">Figure</a>). As indicated, the same result was obtained in Fig 4 of our article, hence, proving that there was no partial volume effect.</p><div id="F1" class="fig pos-float  odd"><div class="highwire-figure"><div class="fig-inline-img-wrapper"><div class="fig-inline-img"><a href="http://ajnr-stage2.stage.highwire.org/content/ajnr/41/4/E21/F1.large.jpg?width=800&amp;height=600&amp;carousel=1" title="Examples of nigrosome-1 visualization in the B0 direction using high resolution (ie, 0.5&#x2009;&#xD7;&#x2009;0.5&#x2009;&#xD7;&#x2009;0.9 mm3), with a right head tilt (A), without a head tilt (B), and with a left head tilt (C)." class="highwire-fragment fragment-images colorbox-load" rel="gallery-fragment-images-1146792778" data-figure-caption="&lt;div class=&quot;highwire-markup&quot;&gt;&lt;div xmlns=&quot;http://www.w3.org/1999/xhtml&quot;&gt;Examples of nigrosome-1 visualization in the B&lt;sub&gt;0&lt;/sub&gt; direction using high resolution (ie, 0.5&#x2009;&#xD7;&#x2009;0.5&#x2009;&#xD7;&#x2009;0.9 mm&lt;sup&gt;3&lt;/sup&gt;), with a right head tilt (&lt;em&gt;A&lt;/em&gt;), without a head tilt (&lt;em&gt;B&lt;/em&gt;), and with a left head tilt (&lt;em&gt;C&lt;/em&gt;).&lt;/div&gt;&lt;/div&gt;" data-icon-position="" data-hide-link-title="0"><span class="hw-responsive-img"><img class="highwire-fragment fragment-image lazyload" alt="Figure." src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-src="http://ajnr-stage2.stage.highwire.org/content/ajnr/41/4/E21/F1.medium.gif" width="440" height="250"/><noscript><img class="highwire-fragment fragment-image" alt="Figure." src="http://ajnr-stage2.stage.highwire.org/content/ajnr/41/4/E21/F1.medium.gif" width="440" height="250"/></noscript></span></a></div></div><ul class="highwire-figure-links inline"><li class="download-fig first"><a href="http://ajnr-stage2.stage.highwire.org/content/ajnr/41/4/E21/F1.large.jpg?download=true" class="highwire-figure-link highwire-figure-link-download" title="Download Figure." data-icon-position="" data-hide-link-title="0">Download figure</a></li><li class="new-tab"><a href="http://ajnr-stage2.stage.highwire.org/content/ajnr/41/4/E21/F1.large.jpg" class="highwire-figure-link highwire-figure-link-newtab" target="_blank" data-icon-position="" data-hide-link-title="0">Open in new tab</a></li><li class="download-ppt last"><a href="/highwire/powerpoint/74425" class="highwire-figure-link highwire-figure-link-ppt" data-icon-position="" data-hide-link-title="0">Download powerpoint</a></li></ul></div><div class="fig-caption" xmlns:xhtml="http://www.w3.org/1999/xhtml"><span class="fig-label">Figure.</span> <p id="p-6" class="first-child">Examples of nigrosome-1 visualization in the B<sub>0</sub> direction using high resolution (ie, 0.5 × 0.5 × 0.9 mm<sup>3</sup>), with a right head tilt (<em>A</em>), without a head tilt (<em>B</em>), and with a left head tilt (<em>C</em>).</p><div class="sb-div caption-clear"></div></div></div><div class="section ref-list" id="ref-list-1"><h2 class="">References</h2><ol class="cit-list ref-use-labels"><li><span class="ref-label">1.</span><a class="rev-xref-ref" href="#xref-ref-1-1" title="View reference 1. in text" id="ref-1">↵</a><div class="cit ref-cit ref-journal" id="cit-41.4.E21.1" data-doi="10.3174/ajnr.A6338"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Arai</span>  <span class="cit-name-given-names">N</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Kan</span>  <span class="cit-name-given-names">H</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Ogawa</span>  <span class="cit-name-given-names">M</span></span>, <span class="cit-etal">et al</span></li></ol><cite>. <span class="cit-article-title">Visualization of nigrosome 1 from the viewpoint of anatomic structure</span>. <abbr 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class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1103/PhysRevA.97.013819</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1103/PhysRevA.97.013819&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a></div></div></li><li><span class="ref-label">5.</span><a class="rev-xref-ref" href="#xref-ref-5-1" title="View reference 5. in text" id="ref-5">↵</a><div class="cit ref-cit ref-journal" id="cit-41.4.E21.5" data-doi="10.1259/bjr.20180842"><div class="cit-metadata"><ol class="cit-auth-list"><li><span class="cit-auth"><span class="cit-name-surname">Kim</span>  <span class="cit-name-given-names">EY</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Sung</span>  <span class="cit-name-given-names">YH</span></span>, </li><li><span class="cit-auth"><span class="cit-name-surname">Lee</span>  <span class="cit-name-given-names">J</span></span></li></ol><cite>. <span class="cit-article-title">Nigrosome 1 imaging: technical considerations and clinical applications</span>. <abbr class="cit-jnl-abbrev">Br J Radiol</abbr> <span class="cit-pub-date">2019</span>;<span class="cit-vol">92</span>:<span class="cit-fpage">20180842</span><span class="cit-pub-id-sep cit-pub-id-doi-sep"> </span><span class="cit-pub-id cit-pub-id-doi"><span class="cit-pub-id-scheme-doi">doi:</span>10.1259/bjr.20180842</span><span class="cit-pub-id-sep cit-pub-id-pmid-sep"> </span><span class="cit-pub-id cit-pub-id-pmid"><span class="cit-pub-id-scheme-pmid">pmid:</span>31067082</span></cite></div><div class="cit-extra"><a href="/lookup/external-ref?access_num=10.1259/bjr.20180842&amp;link_type=DOI" class="cit-ref-sprinkles cit-ref-sprinkles-doi cit-ref-sprinkles-crossref"><span>CrossRef</span></a><a href="/lookup/external-ref?access_num=31067082&amp;link_type=MED&amp;atom=%2Fajnr%2F41%2F4%2FE21.atom" 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