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<meta name="DC.Description" content="A 3-year longitudinal study was conducted with 50 Alzheimer’s disease patients and 45 elderly control subjects. All study participants received an extensive evaluation that included brain CT at baseline and follow-up. Quantitation of ventricular size, using both linear and volume methods, revealed highly significant cross-sectional and longitudinal differences between the Alzheimer patients and control subjects. Specifically, the annual rate of change in ventricular volume was approximately 9% in the Alzheimer patients and approximately 2% in the controls. The presence of age-related white matter lesions had no effect on the clinical course of the patients or on the changes in ventricular size. Among the Alzheimer patients, the rate of clinical decline was strongly related to the rate of change in ventricular size. Baseline ventricular measurements were of no value in predicting the subsequent rate of clinical deterioration or ventricular enlargement.

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      <h1 class="highwire-cite-title" id="page-title">Alzheimer’s Disease: Longitudinal CT Studies of Ventricular Change</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Mony J. de Leon</span>, <span class="highwire-citation-author" data-delta="1">Ajax E. George</span>, <span class="highwire-citation-author" data-delta="2">Barry Reisberg</span>, <span class="highwire-citation-author" data-delta="3">Steven H. Ferris</span>, <span class="highwire-citation-author" data-delta="4">Alan Kluger</span>, <span class="highwire-citation-author" data-delta="5">Leonidas A. Stylopoulos</span>, <span class="highwire-citation-author" data-delta="6">Jeffrey D. Miller</span>, <span class="highwire-citation-author" data-delta="7">Mary Ellen La Regina</span>, <span class="highwire-citation-author" data-delta="8">Clara Chen</span> and <span class="highwire-citation-author" data-delta="9">Jacob Cohen</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">March 1989,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">10 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(2) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">371-376; </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-13378--61709831068" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">Mony J. de Leon </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>1</span> Department of Psychiatry, New York University Medical Center, 550 First Ave., New York, NY 10016. Address reprint requests to M. J. de Leon.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Mony%2BJ.%2Bde%2BLeon%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=de%20Leon%20MJ&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AMony%2BJ.%2Bde%2BLeon%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">Ajax E. George </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>2</span> Department of Radiology, New York University Medical Center, New York, NY 10016.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Ajax%2BE.%2BGeorge%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=George%20AE&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AAjax%2BE.%2BGeorge%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">Barry Reisberg </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>1</span> Department of Psychiatry, New York University Medical Center, 550 First Ave., New York, NY 10016. Address reprint requests to M. J. de Leon.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Barry%2BReisberg%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Reisberg%20B&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3ABarry%2BReisberg%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">Steven H. 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J. de Leon.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Steven%2BH.%2BFerris%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Ferris%20SH&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3ASteven%2BH.%2BFerris%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">Alan Kluger </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>1</span> Department of Psychiatry, New York University Medical Center, 550 First Ave., New York, NY 10016. Address reprint requests to M. J. de Leon.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Alan%2BKluger%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Kluger%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AAlan%2BKluger%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-5"><div class="author-tooltip-name">Leonidas A. 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<p id="p-1">A 3-year longitudinal study was conducted with 50 Alzheimer’s disease patients and 45 elderly control subjects. All study participants received an extensive evaluation that included brain CT at baseline and follow-up. Quantitation of ventricular size, using both linear and volume methods, revealed highly significant cross-sectional and longitudinal differences between the Alzheimer patients and control subjects. Specifically, the annual rate of change in ventricular volume was approximately 9% in the Alzheimer patients and approximately 2% in the controls. The presence of age-related white matter lesions had no effect on the clinical course of the patients or on the changes in ventricular size. Among the Alzheimer patients, the rate of clinical decline was strongly related to the rate of change in ventricular size. Baseline ventricular measurements were of no value in predicting the subsequent rate of clinical deterioration or ventricular enlargement.</p>
<p id="p-2">The results suggest that changes in ventricular size closely reflect the clinical changes in Alzheimer patients.</p>
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 10</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 2 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Mar 1989 </div></div>
      
      
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      <div class="highwire-cite-title">Alzheimer’s Disease: Longitudinal CT Studies of Ventricular Change</div>  
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    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Mar 1989, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">10 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(2) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">371-376; </span></div>
  
  
  
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Mony J.</span> <span class="nlm-surname">de Leon</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Ajax E.</span> <span class="nlm-surname">George</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">Barry</span> <span class="nlm-surname">Reisberg</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Steven H.</span> <span class="nlm-surname">Ferris</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Alan</span> <span class="nlm-surname">Kluger</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Leonidas A.</span> <span class="nlm-surname">Stylopoulos</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">Jeffrey D.</span> <span class="nlm-surname">Miller</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">Mary Ellen</span> <span class="nlm-surname">La Regina</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">Clara</span> <span class="nlm-surname">Chen</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">Jacob</span> <span class="nlm-surname">Cohen</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Mar 1989, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">10 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(2) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">371-376; </span></div>
  
  
  
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