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<meta name="DC.Description" content="Postmortem examinations were made of the brains of six patients, 52-63 years old, who exhibited incidental punctate white matter hyperintensities on MR images before death. Our aim was to unravel the morphologic correlate of such lesions. By repeating the MR study after fixation on four specimens, cutting the brain parallel to the MR imaging plane, and examining whole-hemisphere microscopic sections, we optimized lesion identification. The white matter signal abnormalities were better delineated on pre- than postmortem scans, and visual inspection of the brain slices was normal in all but one location. Histologically, we found areas of reduced myelination with atrophy of the neuropil around fibrohyalinotic arteries as well as different stages of perivenous damage. The latter ranged from spongiform transformation of the neuropil and scattered foci of demyelination to large perivenous areas with marked rarefaction of myelinated fibers. Edematous glial swelling in foci of ganglion cell heterotopia caused subcortical white matter hyperintensities in one case. Our results suggest minor perivascular damage but not infarction as the most likely substrate of punctate MR white matter hyperintensities in elderly brains. Histologic correlations with MR images obtained during life or with studies of unfixed material are necessary to analyze such small lesions." />
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node5414--5" data-node-nid="5414" id="top-node-5414--61160846305" data-pisa="ajnr;12/5/915" data-pisa-master="ajnr;12/5/915" data-apath="/ajnr/12/5/915.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
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      <h1 class="highwire-cite-title" id="page-title">The morphologic correlate of incidental punctate white matter hyperintensities on MR images.</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">F Fazekas</span>, <span class="highwire-citation-author" data-delta="1">R Kleinert</span>, <span class="highwire-citation-author" data-delta="2">H Offenbacher</span>, <span class="highwire-citation-author" data-delta="3">F Payer</span>, <span class="highwire-citation-author" data-delta="4">R Schmidt</span>, <span class="highwire-citation-author" data-delta="5">G Kleinert</span>, <span class="highwire-citation-author" data-delta="6">H Radner</span> and <span class="highwire-citation-author" data-delta="7">H Lechner</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">September 1991,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">12 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(5) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">915-921; </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-5414--61160846305" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">F Fazekas </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'>Department of Neurology, Karl-Franzens University, Graz, Austria.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=F%2BFazekas%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Fazekas%20F&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AF%2BFazekas%2B" rel="nofollow" class="" 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          <a href="/content/12/5" class="highwire-cite-linked-title" data-icon-position="" data-hide-link-title="0"><span class="highwire-cite-title">American Journal of Neuroradiology</span></a>      
      
        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 12</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 5 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Sep 1991 </div></div>
      
      
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      <div class="highwire-cite-title">The morphologic correlate of incidental punctate white matter hyperintensities on MR images.</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">F</span> <span class="nlm-surname">Fazekas</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">R</span> <span class="nlm-surname">Kleinert</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">H</span> <span class="nlm-surname">Offenbacher</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">F</span> <span class="nlm-surname">Payer</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">R</span> <span class="nlm-surname">Schmidt</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">G</span> <span class="nlm-surname">Kleinert</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">H</span> <span class="nlm-surname">Radner</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">H</span> <span class="nlm-surname">Lechner</span></span></span></div>
  
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