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<meta name="DC.Title" content="Proton relaxation enhancement associated with iodinated contrast agents in MR imaging of the CNS." />
<meta name="DC.Date" content="1992-01-01" />
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<meta name="DC.Description" content="PURPOSE To study the effects of iodinated radiographic contrast agents on proton relaxation in MR imaging.

PATIENTS AND METHODS Two patients were evaluated after the intrathecal administration of an iodinated nonionic contrast agent (Isovue) and five subjects with cranial tumors following the intravenous administration of an iodinated ionic contrast medium (Renografin).

RESULTS Both patients with subarachnoid iodinated contrast media demonstrated a relative reduction in T1 and/or T2 times using a spin-echo sequence, while four of five of the subjects with intracranial tumors (one glioma, one dural metastasis, three meningiomas) and intravenous enhancement revealed a visible MR effect. Confirmation of these in vivo observations was obtained by in vitro measurement of T1 and T2 while varying the concentration of the contrast media in saline. All iodinated contrast media showed progressively reduced relaxation times (T1 and T2) as the concentration of the agent was increased. The largest contributing relaxation mechanism is probably due to the binding and exchange of the surrounding water with the contrast molecules.

CONCLUSION The observed T1/T2 effects suggest that administration of iodinated contrast media in the period immediately prior to MR scanning may be contraindicated in selected cases due to the demonstrated alteration of MR signal intensity that may lead to diagnostic inaccuracies." />
<meta name="DC.Contributor" content="J R Jinkins" />
<meta name="DC.Contributor" content="J W Robinson" />
<meta name="DC.Contributor" content="L Sisk" />
<meta name="DC.Contributor" content="G D Fullerton" />
<meta name="DC.Contributor" content="R F Williams" />
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<meta name="citation_abstract" lang="en" content="&lt;h3&gt;PURPOSE&lt;/h3&gt;
&lt;p&gt;To study the effects of iodinated radiographic contrast agents on proton relaxation in MR imaging.&lt;/p&gt;&lt;h3&gt;PATIENTS AND METHODS&lt;/h3&gt;
&lt;p&gt;Two patients were evaluated after the intrathecal administration of an iodinated nonionic contrast agent (Isovue) and five subjects with cranial tumors following the intravenous administration of an iodinated ionic contrast medium (Renografin).&lt;/p&gt;&lt;h3&gt;RESULTS&lt;/h3&gt;
&lt;p&gt;Both patients with subarachnoid iodinated contrast media demonstrated a relative reduction in T1 and/or T2 times using a spin-echo sequence, while four of five of the subjects with intracranial tumors (one glioma, one dural metastasis, three meningiomas) and intravenous enhancement revealed a visible MR effect. Confirmation of these in vivo observations was obtained by in vitro measurement of T1 and T2 while varying the concentration of the contrast media in saline. All iodinated contrast media showed progressively reduced relaxation times (T1 and T2) as the concentration of the agent was increased. The largest contributing relaxation mechanism is probably due to the binding and exchange of the surrounding water with the contrast molecules.&lt;/p&gt;&lt;h3&gt;CONCLUSION&lt;/h3&gt;
&lt;p&gt;The observed T1/T2 effects suggest that administration of iodinated contrast media in the period immediately prior to MR scanning may be contraindicated in selected cases due to the demonstrated alteration of MR signal intensity that may lead to diagnostic inaccuracies.&lt;/p&gt;" />
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<meta name="citation_author" content="J R Jinkins" />
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<meta name="citation_author" content="J W Robinson" />
<meta name="citation_author_institution" content="Department of Radiology, University of Texas Health Science Center, San Antonio 78284-7800." />
<meta name="citation_author" content="L Sisk" />
<meta name="citation_author_institution" content="Department of Radiology, University of Texas Health Science Center, San Antonio 78284-7800." />
<meta name="citation_author" content="G D Fullerton" />
<meta name="citation_author_institution" content="Department of Radiology, University of Texas Health Science Center, San Antonio 78284-7800." />
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<meta name="twitter:title" content="Proton relaxation enhancement associated with iodinated contrast agents in MR imaging of the CNS." />
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<meta name="twitter:description" content="PURPOSE To study the effects of iodinated radiographic contrast agents on proton relaxation in MR imaging.

PATIENTS AND METHODS Two patients were evaluated after the intrathecal administration of an iodinated nonionic contrast agent (Isovue) and five subjects with cranial tumors following the intravenous administration of an iodinated ionic contrast medium (Renografin).

RESULTS Both patients with subarachnoid iodinated contrast media demonstrated a relative reduction in T1 and/or T2 times using a spin-echo sequence, while four of five of the subjects with intracranial tumors (one glioma, one dural metastasis, three meningiomas) and intravenous enhancement revealed a visible MR effect. Confirmation of these in vivo observations was obtained by in vitro measurement of T1 and T2 while varying the concentration of the contrast media in saline. All iodinated contrast media showed progressively reduced relaxation times (T1 and T2) as the concentration of the agent was increased. The largest contributing relaxation mechanism is probably due to the binding and exchange of the surrounding water with the contrast molecules.

CONCLUSION The observed T1/T2 effects suggest that administration of iodinated contrast media in the period immediately prior to MR scanning may be contraindicated in selected cases due to the demonstrated alteration of MR signal intensity that may lead to diagnostic inaccuracies." />
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<meta name="og-description" property="og:description" content="PURPOSE To study the effects of iodinated radiographic contrast agents on proton relaxation in MR imaging.

PATIENTS AND METHODS Two patients were evaluated after the intrathecal administration of an iodinated nonionic contrast agent (Isovue) and five subjects with cranial tumors following the intravenous administration of an iodinated ionic contrast medium (Renografin).

RESULTS Both patients with subarachnoid iodinated contrast media demonstrated a relative reduction in T1 and/or T2 times using a spin-echo sequence, while four of five of the subjects with intracranial tumors (one glioma, one dural metastasis, three meningiomas) and intravenous enhancement revealed a visible MR effect. Confirmation of these in vivo observations was obtained by in vitro measurement of T1 and T2 while varying the concentration of the contrast media in saline. All iodinated contrast media showed progressively reduced relaxation times (T1 and T2) as the concentration of the agent was increased. The largest contributing relaxation mechanism is probably due to the binding and exchange of the surrounding water with the contrast molecules.

CONCLUSION The observed T1/T2 effects suggest that administration of iodinated contrast media in the period immediately prior to MR scanning may be contraindicated in selected cases due to the demonstrated alteration of MR signal intensity that may lead to diagnostic inaccuracies." />
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      <h1 class="highwire-cite-title" id="page-title">Proton relaxation enhancement associated with iodinated contrast agents in MR imaging of the CNS.</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">J R Jinkins</span>, <span class="highwire-citation-author" data-delta="1">J W Robinson</span>, <span class="highwire-citation-author" data-delta="2">L Sisk</span>, <span class="highwire-citation-author" data-delta="3">G D Fullerton</span> and <span class="highwire-citation-author" data-delta="4">R F Williams</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">January 1992,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">13 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(1) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">19-27; </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-5560--81521733891" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">J R Jinkins </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'>Department of Radiology, University of Texas Health Science Center, San Antonio 78284-7800.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J%2BR%2BJinkins%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Jinkins%20JR&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a 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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 13</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 1 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Jan 1992 </div></div>
      
      
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