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<meta name="DC.Title" content="Metastatic adenocarcinoma to the brain: MR with pathologic correlation." />
<meta name="DC.Date" content="1994-01-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
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<meta name="DC.Description" content="PURPOSE To describe the appearance on T2-weighted scans of metastatic adenocarcinoma to the brain and to show that the hypointensity frequently associated with these lesions is not related to the presence of mucin, blood products, iron, or calcium.

METHODS The MR scans of 14 patients with metastatic adenocarcinoma to the brain were reviewed retrospectively. The signal intensity on T2-weighted scans of the solid enhancing portion of the tumors was compared with white matter. Histologic examination of the surgical specimens included special stains to search for calcium, mucin, and iron.

RESULTS Eight of nine surgical and all six nonsurgical lesions were either iso- or hypointense to white matter on T2-weighted scans. There was no correlation with tumor histology or the presence of mucin, blood products, iron, or calcium.

CONCLUSIONS The presence of a hypointense intraaxial mass on T2-weighted scans strongly suggests the possibility of metastatic adenocarcinoma. The MR appearance is not explained by the presence of mucin, blood products, iron, or calcium. This phenomenon most likely reflects the relaxation parameters of the tissue from which the metastasis arose." />
<meta name="DC.Contributor" content="D A Carrier" />
<meta name="DC.Contributor" content="M E Mawad" />
<meta name="DC.Contributor" content="J B Kirkpatrick" />
<meta name="DC.Contributor" content="M F Schmid" />
<meta name="article:published_time" content="1994-01-01" />
<meta name="citation_title" content="Metastatic adenocarcinoma to the brain: MR with pathologic correlation." />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;PURPOSE&lt;/h3&gt;
&lt;p&gt;To describe the appearance on T2-weighted scans of metastatic adenocarcinoma to the brain and to show that the hypointensity frequently associated with these lesions is not related to the presence of mucin, blood products, iron, or calcium.&lt;/p&gt;&lt;h3&gt;METHODS&lt;/h3&gt;
&lt;p&gt;The MR scans of 14 patients with metastatic adenocarcinoma to the brain were reviewed retrospectively. The signal intensity on T2-weighted scans of the solid enhancing portion of the tumors was compared with white matter. Histologic examination of the surgical specimens included special stains to search for calcium, mucin, and iron.&lt;/p&gt;&lt;h3&gt;RESULTS&lt;/h3&gt;
&lt;p&gt;Eight of nine surgical and all six nonsurgical lesions were either iso- or hypointense to white matter on T2-weighted scans. There was no correlation with tumor histology or the presence of mucin, blood products, iron, or calcium.&lt;/p&gt;&lt;h3&gt;CONCLUSIONS&lt;/h3&gt;
&lt;p&gt;The presence of a hypointense intraaxial mass on T2-weighted scans strongly suggests the possibility of metastatic adenocarcinoma. The MR appearance is not explained by the presence of mucin, blood products, iron, or calcium. This phenomenon most likely reflects the relaxation parameters of the tissue from which the metastasis arose.&lt;/p&gt;" />
<meta name="citation_journal_title" content="American Journal of Neuroradiology" />
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<meta name="citation_publication_date" content="1994/01/01" />
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<meta name="citation_issn" content="0195-6108" />
<meta name="citation_issn" content="1936-959X" />
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<meta name="citation_author" content="D A Carrier" />
<meta name="citation_author_institution" content="Wilford Hall USAF Medical Center/PSRD, Dept of Radiology, Lackland AFB, TX 78236-5300." />
<meta name="citation_author" content="M E Mawad" />
<meta name="citation_author_institution" content="Wilford Hall USAF Medical Center/PSRD, Dept of Radiology, Lackland AFB, TX 78236-5300." />
<meta name="citation_author" content="J B Kirkpatrick" />
<meta name="citation_author_institution" content="Wilford Hall USAF Medical Center/PSRD, Dept of Radiology, Lackland AFB, TX 78236-5300." />
<meta name="citation_author" content="M F Schmid" />
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<meta name="twitter:title" content="Metastatic adenocarcinoma to the brain: MR with pathologic correlation." />
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<meta name="twitter:description" content="PURPOSE To describe the appearance on T2-weighted scans of metastatic adenocarcinoma to the brain and to show that the hypointensity frequently associated with these lesions is not related to the presence of mucin, blood products, iron, or calcium.

METHODS The MR scans of 14 patients with metastatic adenocarcinoma to the brain were reviewed retrospectively. The signal intensity on T2-weighted scans of the solid enhancing portion of the tumors was compared with white matter. Histologic examination of the surgical specimens included special stains to search for calcium, mucin, and iron.

RESULTS Eight of nine surgical and all six nonsurgical lesions were either iso- or hypointense to white matter on T2-weighted scans. There was no correlation with tumor histology or the presence of mucin, blood products, iron, or calcium.

CONCLUSIONS The presence of a hypointense intraaxial mass on T2-weighted scans strongly suggests the possibility of metastatic adenocarcinoma. The MR appearance is not explained by the presence of mucin, blood products, iron, or calcium. This phenomenon most likely reflects the relaxation parameters of the tissue from which the metastasis arose." />
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<meta name="og-description" property="og:description" content="PURPOSE To describe the appearance on T2-weighted scans of metastatic adenocarcinoma to the brain and to show that the hypointensity frequently associated with these lesions is not related to the presence of mucin, blood products, iron, or calcium.

METHODS The MR scans of 14 patients with metastatic adenocarcinoma to the brain were reviewed retrospectively. The signal intensity on T2-weighted scans of the solid enhancing portion of the tumors was compared with white matter. Histologic examination of the surgical specimens included special stains to search for calcium, mucin, and iron.

RESULTS Eight of nine surgical and all six nonsurgical lesions were either iso- or hypointense to white matter on T2-weighted scans. There was no correlation with tumor histology or the presence of mucin, blood products, iron, or calcium.

CONCLUSIONS The presence of a hypointense intraaxial mass on T2-weighted scans strongly suggests the possibility of metastatic adenocarcinoma. The MR appearance is not explained by the presence of mucin, blood products, iron, or calcium. This phenomenon most likely reflects the relaxation parameters of the tissue from which the metastasis arose." />
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      <h1 class="highwire-cite-title" id="page-title">Metastatic adenocarcinoma to the brain: MR with pathologic correlation.</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">D A Carrier</span>, <span class="highwire-citation-author" data-delta="1">M E Mawad</span>, <span class="highwire-citation-author" data-delta="2">J B Kirkpatrick</span> and <span class="highwire-citation-author" data-delta="3">M F Schmid</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">January 1994,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">15 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(1) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">155-159; </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-5920--61415146144" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">D A Carrier </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'>Wilford Hall USAF Medical Center/PSRD, Dept of Radiology, Lackland AFB, TX 78236-5300.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=D%2BA%2BCarrier%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Carrier%20DA&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AD%2BA%2BCarrier%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">M E Mawad </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'>Wilford Hall USAF Medical Center/PSRD, Dept of Radiology, Lackland AFB, TX 78236-5300.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M%2BE%2BMawad%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Mawad%20ME&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AM%2BE%2BMawad%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">J B Kirkpatrick </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'>Wilford Hall USAF Medical Center/PSRD, Dept of Radiology, Lackland AFB, TX 78236-5300.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J%2BB%2BKirkpatrick%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Kirkpatrick%20JB&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AJ%2BB%2BKirkpatrick%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">M F Schmid </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'>Wilford Hall USAF Medical Center/PSRD, Dept of Radiology, Lackland AFB, TX 78236-5300.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M%2BF%2BSchmid%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Schmid%20MF&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AM%2BF%2BSchmid%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div></div></div>  </div>

  
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          <div id="sec-1" class="subsection"><p id="p-1"><strong>PURPOSE</strong> To describe the appearance on T2-weighted scans of metastatic adenocarcinoma to the brain and to show that the hypointensity frequently associated with these lesions is not related to the presence of mucin, blood products, iron, or calcium.</p></div>
          <div id="sec-2" class="subsection"><p id="p-2"><strong>METHODS</strong> The MR scans of 14 patients with metastatic adenocarcinoma to the brain were reviewed retrospectively. The signal intensity on T2-weighted scans of the solid enhancing portion of the tumors was compared with white matter. Histologic examination of the surgical specimens included special stains to search for calcium, mucin, and iron.</p></div>
          <div id="sec-3" class="subsection"><p id="p-3"><strong>RESULTS</strong> Eight of nine surgical and all six nonsurgical lesions were either iso- or hypointense to white matter on T2-weighted scans. There was no correlation with tumor histology or the presence of mucin, blood products, iron, or calcium.</p></div>
          <div id="sec-4" class="subsection"><p id="p-4"><strong>CONCLUSIONS</strong> The presence of a hypointense intraaxial mass on T2-weighted scans strongly suggests the possibility of metastatic adenocarcinoma. The MR appearance is not explained by the presence of mucin, blood products, iron, or calcium. This phenomenon most likely reflects the relaxation parameters of the tissue from which the metastasis arose.</p></div>
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">D A</span> <span class="nlm-surname">Carrier</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">M E</span> <span class="nlm-surname">Mawad</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">J B</span> <span class="nlm-surname">Kirkpatrick</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">M F</span> <span class="nlm-surname">Schmid</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Jan 1994, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">15 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(1) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">155-159; </span></div>
  
  
  
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