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<meta name="DC.Title" content="In vitro evaluation of papaverine hydrochloride incompatibilities: a simulation of intraarterial infusion for cerebral vasospasm." />
<meta name="DC.Date" content="1994-10-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
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<meta name="DC.Description" content="PURPOSE To elucidate, in light of reports of complications associated with intraarterial infusion of papaverine hydrochloride, the known propensity of papaverine hydrochloride to form precipitate in combination with other solutions or pharmaceuticals.

METHODS Initially simulating a situation experienced during an intraarterial papaverine infusion for cerebral vasospasm, we mixed various concentrations of papaverine with serum, nonheparinized and heparinized saline, and nonionic contrast material.

RESULTS Papaverine in concentrations of 0.3% (300 mg/100 mL of normal saline) or greater formed a precipitate when mixed with human serum (blood). The precipitate crystals were 50 to 100 microns in size and could be returned to solution simply by the addition of more serum.

CONCLUSION Crystal emboli are a possible transient cause of complications experienced during treatment of vasospasm with its attendant altered flow dynamics." />
<meta name="DC.Contributor" content="J M Mathis" />
<meta name="DC.Contributor" content="A J DeNardo" />
<meta name="DC.Contributor" content="L Thibault" />
<meta name="DC.Contributor" content="M E Jensen" />
<meta name="DC.Contributor" content="J Savory" />
<meta name="DC.Contributor" content="J E Dion" />
<meta name="article:published_time" content="1994-10-01" />
<meta name="citation_title" content="In vitro evaluation of papaverine hydrochloride incompatibilities: a simulation of intraarterial infusion for cerebral vasospasm." />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;PURPOSE&lt;/h3&gt;
&lt;p&gt;To elucidate, in light of reports of complications associated with intraarterial infusion of papaverine hydrochloride, the known propensity of papaverine hydrochloride to form precipitate in combination with other solutions or pharmaceuticals.&lt;/p&gt;&lt;h3&gt;METHODS&lt;/h3&gt;
&lt;p&gt;Initially simulating a situation experienced during an intraarterial papaverine infusion for cerebral vasospasm, we mixed various concentrations of papaverine with serum, nonheparinized and heparinized saline, and nonionic contrast material.&lt;/p&gt;&lt;h3&gt;RESULTS&lt;/h3&gt;
&lt;p&gt;Papaverine in concentrations of 0.3% (300 mg/100 mL of normal saline) or greater formed a precipitate when mixed with human serum (blood). The precipitate crystals were 50 to 100 microns in size and could be returned to solution simply by the addition of more serum.&lt;/p&gt;&lt;h3&gt;CONCLUSION&lt;/h3&gt;
&lt;p&gt;Crystal emboli are a possible transient cause of complications experienced during treatment of vasospasm with its attendant altered flow dynamics.&lt;/p&gt;" />
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<meta name="citation_author" content="J M Mathis" />
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<meta name="citation_author" content="A J DeNardo" />
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<meta name="citation_author" content="L Thibault" />
<meta name="citation_author_institution" content="Division of Neuroradiology, University of Virginia Health Sciences Center, Charlottesville 22908." />
<meta name="citation_author" content="M E Jensen" />
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<meta name="twitter:title" content="In vitro evaluation of papaverine hydrochloride incompatibilities: a simulation of intraarterial infusion for cerebral vasospasm." />
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<meta name="twitter:description" content="PURPOSE To elucidate, in light of reports of complications associated with intraarterial infusion of papaverine hydrochloride, the known propensity of papaverine hydrochloride to form precipitate in combination with other solutions or pharmaceuticals.

METHODS Initially simulating a situation experienced during an intraarterial papaverine infusion for cerebral vasospasm, we mixed various concentrations of papaverine with serum, nonheparinized and heparinized saline, and nonionic contrast material.

RESULTS Papaverine in concentrations of 0.3% (300 mg/100 mL of normal saline) or greater formed a precipitate when mixed with human serum (blood). The precipitate crystals were 50 to 100 microns in size and could be returned to solution simply by the addition of more serum.

CONCLUSION Crystal emboli are a possible transient cause of complications experienced during treatment of vasospasm with its attendant altered flow dynamics." />
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<meta name="og-description" property="og:description" content="PURPOSE To elucidate, in light of reports of complications associated with intraarterial infusion of papaverine hydrochloride, the known propensity of papaverine hydrochloride to form precipitate in combination with other solutions or pharmaceuticals.

METHODS Initially simulating a situation experienced during an intraarterial papaverine infusion for cerebral vasospasm, we mixed various concentrations of papaverine with serum, nonheparinized and heparinized saline, and nonionic contrast material.

RESULTS Papaverine in concentrations of 0.3% (300 mg/100 mL of normal saline) or greater formed a precipitate when mixed with human serum (blood). The precipitate crystals were 50 to 100 microns in size and could be returned to solution simply by the addition of more serum.

CONCLUSION Crystal emboli are a possible transient cause of complications experienced during treatment of vasospasm with its attendant altered flow dynamics." />
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      <h1 class="highwire-cite-title" id="page-title">In vitro evaluation of papaverine hydrochloride incompatibilities: a simulation of intraarterial infusion for cerebral vasospasm.</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">J M Mathis</span>, <span class="highwire-citation-author" data-delta="1">A J DeNardo</span>, <span class="highwire-citation-author" data-delta="2">L Thibault</span>, <span class="highwire-citation-author" data-delta="3">M E Jensen</span>, <span class="highwire-citation-author" data-delta="4">J Savory</span> and <span class="highwire-citation-author" data-delta="5">J E Dion</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">October 1994,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">15 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(9) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1665-1670; </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-6150--61686297009" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">J M Mathis </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'>Division of Neuroradiology, University of Virginia Health Sciences Center, Charlottesville 22908.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J%2BM%2BMathis%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Mathis%20JM&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a 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          <p id="p-1"><strong>PURPOSE</strong> To elucidate, in light of reports of complications associated with intraarterial infusion of papaverine hydrochloride, the known propensity of papaverine hydrochloride to form precipitate in combination with other solutions or pharmaceuticals.</p>
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          <p id="p-2"><strong>METHODS</strong> Initially simulating a situation experienced during an intraarterial papaverine infusion for cerebral vasospasm, we mixed various concentrations of papaverine with serum, nonheparinized and heparinized saline, and nonionic contrast material.</p>
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          <p id="p-3"><strong>RESULTS</strong> Papaverine in concentrations of 0.3% (300 mg/100 mL of normal saline) or greater formed a precipitate when mixed with human serum (blood). The precipitate crystals were 50 to 100 microns in size and could be returned to solution simply by the addition of more serum.</p>
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          <p id="p-4"><strong>CONCLUSION</strong> Crystal emboli are a possible transient cause of complications experienced during treatment of vasospasm with its attendant altered flow dynamics.</p>
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 15</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 9 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Oct 1994 </div></div>
      
      
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      <div class="highwire-cite-title">In vitro evaluation of papaverine hydrochloride incompatibilities: a simulation of intraarterial infusion for cerebral vasospasm.</div>  
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