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<meta name="DC.Title" content="Childhood cerebral form of adrenoleukodystrophy: short-term effect of bone marrow transplantation on brain MR observations." />
<meta name="DC.Date" content="1994-10-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="Copyright © American Society of Neuroradiology" />
<meta name="DC.AccessRights" content="restricted" />
<meta name="DC.Description" content="PURPOSE To report the serial brain MR observations in patients with childhood-onset cerebral adrenoleukodystrophy 1 to 2 years after bone marrow transplantation.

METHODS Eight boys with childhood-onset cerebral adrenoleukodystrophy have undergone successful transplantation at our institution. Seven patients (mean age, 8 years 10 months; range, 5 years 3 months to 11 years 9 months) had serial MR studies before and after transplantation. An MR severity score (0 to 34) based on disease location and the presence or absence of focal atrophy was calculated for each patient scan.

RESULTS Posttransplantation serial MR showed improvement in two patients, stabilization in three patients, and worsening of MR signal changes in two patients. The patient with the most striking progression had systemic graft-versus-host disease. Although the adrenoleukodystrophy MR severity score did not change in three patients after transplantation, two of these patients did show improved margination of disease.

CONCLUSION Bone marrow transplantation can affect brain MR observations in childhood-onset cerebral adrenoleukodystrophy. Although brain MR findings do not typically resolve, they do seem to stabilize, which is an improvement over the natural MR history of the disease." />
<meta name="DC.Contributor" content="D J Loes" />
<meta name="DC.Contributor" content="A E Stillman" />
<meta name="DC.Contributor" content="S Hite" />
<meta name="DC.Contributor" content="E Shapiro" />
<meta name="DC.Contributor" content="L Lockman" />
<meta name="DC.Contributor" content="R E Latchaw" />
<meta name="DC.Contributor" content="H Moser" />
<meta name="DC.Contributor" content="W Krivit" />
<meta name="article:published_time" content="1994-10-01" />
<meta name="citation_title" content="Childhood cerebral form of adrenoleukodystrophy: short-term effect of bone marrow transplantation on brain MR observations." />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;PURPOSE&lt;/h3&gt;
&lt;p&gt;To report the serial brain MR observations in patients with childhood-onset cerebral adrenoleukodystrophy 1 to 2 years after bone marrow transplantation.&lt;/p&gt;&lt;h3&gt;METHODS&lt;/h3&gt;
&lt;p&gt;Eight boys with childhood-onset cerebral adrenoleukodystrophy have undergone successful transplantation at our institution. Seven patients (mean age, 8 years 10 months; range, 5 years 3 months to 11 years 9 months) had serial MR studies before and after transplantation. An MR severity score (0 to 34) based on disease location and the presence or absence of focal atrophy was calculated for each patient scan.&lt;/p&gt;&lt;h3&gt;RESULTS&lt;/h3&gt;
&lt;p&gt;Posttransplantation serial MR showed improvement in two patients, stabilization in three patients, and worsening of MR signal changes in two patients. The patient with the most striking progression had systemic graft-versus-host disease. Although the adrenoleukodystrophy MR severity score did not change in three patients after transplantation, two of these patients did show improved margination of disease.&lt;/p&gt;&lt;h3&gt;CONCLUSION&lt;/h3&gt;
&lt;p&gt;Bone marrow transplantation can affect brain MR observations in childhood-onset cerebral adrenoleukodystrophy. Although brain MR findings do not typically resolve, they do seem to stabilize, which is an improvement over the natural MR history of the disease.&lt;/p&gt;" />
<meta name="citation_journal_title" content="American Journal of Neuroradiology" />
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<meta name="citation_author" content="D J Loes" />
<meta name="citation_author_institution" content="University of Minnesota Hospital and Clinic, Department of Radiology, Minneapolis 55455." />
<meta name="citation_author" content="A E Stillman" />
<meta name="citation_author_institution" content="University of Minnesota Hospital and Clinic, Department of Radiology, Minneapolis 55455." />
<meta name="citation_author" content="S Hite" />
<meta name="citation_author_institution" content="University of Minnesota Hospital and Clinic, Department of Radiology, Minneapolis 55455." />
<meta name="citation_author" content="E Shapiro" />
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<meta name="citation_author" content="L Lockman" />
<meta name="citation_author_institution" content="University of Minnesota Hospital and Clinic, Department of Radiology, Minneapolis 55455." />
<meta name="citation_author" content="R E Latchaw" />
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<meta name="citation_author" content="H Moser" />
<meta name="citation_author_institution" content="University of Minnesota Hospital and Clinic, Department of Radiology, Minneapolis 55455." />
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<meta name="twitter:title" content="Childhood cerebral form of adrenoleukodystrophy: short-term effect of bone marrow transplantation on brain MR observations." />
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<meta name="twitter:description" content="PURPOSE To report the serial brain MR observations in patients with childhood-onset cerebral adrenoleukodystrophy 1 to 2 years after bone marrow transplantation.

METHODS Eight boys with childhood-onset cerebral adrenoleukodystrophy have undergone successful transplantation at our institution. Seven patients (mean age, 8 years 10 months; range, 5 years 3 months to 11 years 9 months) had serial MR studies before and after transplantation. An MR severity score (0 to 34) based on disease location and the presence or absence of focal atrophy was calculated for each patient scan.

RESULTS Posttransplantation serial MR showed improvement in two patients, stabilization in three patients, and worsening of MR signal changes in two patients. The patient with the most striking progression had systemic graft-versus-host disease. Although the adrenoleukodystrophy MR severity score did not change in three patients after transplantation, two of these patients did show improved margination of disease.

CONCLUSION Bone marrow transplantation can affect brain MR observations in childhood-onset cerebral adrenoleukodystrophy. Although brain MR findings do not typically resolve, they do seem to stabilize, which is an improvement over the natural MR history of the disease." />
<meta name="og-title" property="og:title" content="Childhood cerebral form of adrenoleukodystrophy: short-term effect of bone marrow transplantation on brain MR observations." />
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<meta name="og-description" property="og:description" content="PURPOSE To report the serial brain MR observations in patients with childhood-onset cerebral adrenoleukodystrophy 1 to 2 years after bone marrow transplantation.

METHODS Eight boys with childhood-onset cerebral adrenoleukodystrophy have undergone successful transplantation at our institution. Seven patients (mean age, 8 years 10 months; range, 5 years 3 months to 11 years 9 months) had serial MR studies before and after transplantation. An MR severity score (0 to 34) based on disease location and the presence or absence of focal atrophy was calculated for each patient scan.

RESULTS Posttransplantation serial MR showed improvement in two patients, stabilization in three patients, and worsening of MR signal changes in two patients. The patient with the most striking progression had systemic graft-versus-host disease. Although the adrenoleukodystrophy MR severity score did not change in three patients after transplantation, two of these patients did show improved margination of disease.

CONCLUSION Bone marrow transplantation can affect brain MR observations in childhood-onset cerebral adrenoleukodystrophy. Although brain MR findings do not typically resolve, they do seem to stabilize, which is an improvement over the natural MR history of the disease." />
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      <h1 class="highwire-cite-title" id="page-title">Childhood cerebral form of adrenoleukodystrophy: short-term effect of bone marrow transplantation on brain MR observations.</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">D J Loes</span>, <span class="highwire-citation-author" data-delta="1">A E Stillman</span>, <span class="highwire-citation-author" data-delta="2">S Hite</span>, <span class="highwire-citation-author" data-delta="3">E Shapiro</span>, <span class="highwire-citation-author" data-delta="4">L Lockman</span>, <span class="highwire-citation-author" data-delta="5">R E Latchaw</span>, <span class="highwire-citation-author" data-delta="6">H Moser</span> and <span class="highwire-citation-author" data-delta="7">W Krivit</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">October 1994,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">15 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(9) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1767-1771; </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-6155--61534139192" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">D J Loes </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'>University of Minnesota Hospital and Clinic, Department of Radiology, Minneapolis 55455.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=D%2BJ%2BLoes%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Loes%20DJ&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AD%2BJ%2BLoes%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">A E Stillman </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'>University of Minnesota Hospital and Clinic, Department of Radiology, Minneapolis 55455.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A%2BE%2BStillman%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Stillman%20AE&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a 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          <p id="p-1"><strong>PURPOSE</strong> To report the serial brain MR observations in patients with childhood-onset cerebral adrenoleukodystrophy 1 to 2 years after bone marrow transplantation.</p>
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          <p id="p-2"><strong>METHODS</strong> Eight boys with childhood-onset cerebral adrenoleukodystrophy have undergone successful transplantation at our institution. Seven patients (mean age, 8 years 10 months; range, 5 years 3 months to 11 years 9 months) had serial MR studies before and after transplantation. An MR severity score (0 to 34) based on disease location and the presence or absence of focal atrophy was calculated for each patient scan.</p>
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          <p id="p-3"><strong>RESULTS</strong> Posttransplantation serial MR showed improvement in two patients, stabilization in three patients, and worsening of MR signal changes in two patients. The patient with the most striking progression had systemic graft-versus-host disease. Although the adrenoleukodystrophy MR severity score did not change in three patients after transplantation, two of these patients did show improved margination of disease.</p>
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          <p id="p-4"><strong>CONCLUSION</strong> Bone marrow transplantation can affect brain MR observations in childhood-onset cerebral adrenoleukodystrophy. Although brain MR findings do not typically resolve, they do seem to stabilize, which is an improvement over the natural MR history of the disease.</p>
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 15</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 9 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Oct 1994 </div></div>
      
      
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