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<meta name="DC.Title" content="Sensitivity of enhanced MR in multiple sclerosis: effects of contrast dose and magnetization transfer contrast." />
<meta name="DC.Date" content="1998-11-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="Copyright © American Society of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSES New strategies have been developed to improve the sensitivity of contrast-enhanced MR imaging in quantifying disease activity in patients with multiple sclerosis (MS). The goal of the present study was to evaluate the sensitivity of T1-weighted images after injection of a triple dose of contrast material and application of a magnetization transfer (MT) pulse in the detection of enhancing lesions as compared with the conventional approach.

METHODS Monthly MR images were obtained in 13 patients with relapsing-remitting MS for a period of 3 months. The MR studies were performed on two separate occasions with single- and triple-dose contrast material. In each session, T1- and T2-weighted spin-echo images with and without the MT pulse were obtained before and after contrast administration. All images were evaluated in a blinded fashion and scored in random order and consensually by two readers. The number of total and new enhancing lesions and active images was counted.

RESULTS Eighty-six percent more enhancing lesions and 54% more new enhancing lesions were detected with triple-dose as compared with single-dose non-MT sequences, whereas single-dose MT images depicted 33% more enhancing lesions and 18% more new enhancing lesions than the single-dose non-MT images. Twenty-nine percent more lesions were detected on triple-dose non-MT images than on single-dose MT images. The combination of a triple dose of contrast material and MT did not produce any significant change in detection of enhancing lesions as compared with a triple dose of contrast without MT.

CONCLUSION The use of a triple dose of contrast material is the best approach to maximize the sensitivity of enhanced MR imaging." />
<meta name="DC.Contributor" content="S Bastianello" />
<meta name="DC.Contributor" content="C Gasperini" />
<meta name="DC.Contributor" content="A Paolillo" />
<meta name="DC.Contributor" content="E Giugni" />
<meta name="DC.Contributor" content="O Ciccarelli" />
<meta name="DC.Contributor" content="M P Sormani" />
<meta name="DC.Contributor" content="M A Horsfield" />
<meta name="DC.Contributor" content="M Rovaris" />
<meta name="DC.Contributor" content="C Pozzilli" />
<meta name="DC.Contributor" content="M Filippi" />
<meta name="article:published_time" content="1998-11-01" />
<meta name="citation_title" content="Sensitivity of enhanced MR in multiple sclerosis: effects of contrast dose and magnetization transfer contrast." />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSES&lt;/h3&gt;
&lt;p&gt;New strategies have been developed to improve the sensitivity of contrast-enhanced MR imaging in quantifying disease activity in patients with multiple sclerosis (MS). The goal of the present study was to evaluate the sensitivity of T1-weighted images after injection of a triple dose of contrast material and application of a magnetization transfer (MT) pulse in the detection of enhancing lesions as compared with the conventional approach.&lt;/p&gt;&lt;h3&gt;METHODS&lt;/h3&gt;
&lt;p&gt;Monthly MR images were obtained in 13 patients with relapsing-remitting MS for a period of 3 months. The MR studies were performed on two separate occasions with single- and triple-dose contrast material. In each session, T1- and T2-weighted spin-echo images with and without the MT pulse were obtained before and after contrast administration. All images were evaluated in a blinded fashion and scored in random order and consensually by two readers. The number of total and new enhancing lesions and active images was counted.&lt;/p&gt;&lt;h3&gt;RESULTS&lt;/h3&gt;
&lt;p&gt;Eighty-six percent more enhancing lesions and 54% more new enhancing lesions were detected with triple-dose as compared with single-dose non-MT sequences, whereas single-dose MT images depicted 33% more enhancing lesions and 18% more new enhancing lesions than the single-dose non-MT images. Twenty-nine percent more lesions were detected on triple-dose non-MT images than on single-dose MT images. The combination of a triple dose of contrast material and MT did not produce any significant change in detection of enhancing lesions as compared with a triple dose of contrast without MT.&lt;/p&gt;&lt;h3&gt;CONCLUSION&lt;/h3&gt;
&lt;p&gt;The use of a triple dose of contrast material is the best approach to maximize the sensitivity of enhanced MR imaging.&lt;/p&gt;" />
<meta name="citation_journal_title" content="American Journal of Neuroradiology" />
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<meta name="citation_issn" content="0195-6108" />
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<meta name="citation_article_type" content="Abstract" />
<meta name="citation_firstpage" content="1863" />
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<meta name="citation_author" content="S Bastianello" />
<meta name="citation_author" content="C Gasperini" />
<meta name="citation_author" content="A Paolillo" />
<meta name="citation_author" content="E Giugni" />
<meta name="citation_author" content="O Ciccarelli" />
<meta name="citation_author" content="M P Sormani" />
<meta name="citation_author" content="M A Horsfield" />
<meta name="citation_author" content="M Rovaris" />
<meta name="citation_author" content="C Pozzilli" />
<meta name="citation_author" content="M Filippi" />
<meta name="twitter:title" content="Sensitivity of enhanced MR in multiple sclerosis: effects of contrast dose and magnetization transfer contrast." />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSES New strategies have been developed to improve the sensitivity of contrast-enhanced MR imaging in quantifying disease activity in patients with multiple sclerosis (MS). The goal of the present study was to evaluate the sensitivity of T1-weighted images after injection of a triple dose of contrast material and application of a magnetization transfer (MT) pulse in the detection of enhancing lesions as compared with the conventional approach.

METHODS Monthly MR images were obtained in 13 patients with relapsing-remitting MS for a period of 3 months. The MR studies were performed on two separate occasions with single- and triple-dose contrast material. In each session, T1- and T2-weighted spin-echo images with and without the MT pulse were obtained before and after contrast administration. All images were evaluated in a blinded fashion and scored in random order and consensually by two readers. The number of total and new enhancing lesions and active images was counted.

RESULTS Eighty-six percent more enhancing lesions and 54% more new enhancing lesions were detected with triple-dose as compared with single-dose non-MT sequences, whereas single-dose MT images depicted 33% more enhancing lesions and 18% more new enhancing lesions than the single-dose non-MT images. Twenty-nine percent more lesions were detected on triple-dose non-MT images than on single-dose MT images. The combination of a triple dose of contrast material and MT did not produce any significant change in detection of enhancing lesions as compared with a triple dose of contrast without MT.

CONCLUSION The use of a triple dose of contrast material is the best approach to maximize the sensitivity of enhanced MR imaging." />
<meta name="og-title" property="og:title" content="Sensitivity of enhanced MR in multiple sclerosis: effects of contrast dose and magnetization transfer contrast." />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/19/10/1863" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSES New strategies have been developed to improve the sensitivity of contrast-enhanced MR imaging in quantifying disease activity in patients with multiple sclerosis (MS). The goal of the present study was to evaluate the sensitivity of T1-weighted images after injection of a triple dose of contrast material and application of a magnetization transfer (MT) pulse in the detection of enhancing lesions as compared with the conventional approach.

METHODS Monthly MR images were obtained in 13 patients with relapsing-remitting MS for a period of 3 months. The MR studies were performed on two separate occasions with single- and triple-dose contrast material. In each session, T1- and T2-weighted spin-echo images with and without the MT pulse were obtained before and after contrast administration. All images were evaluated in a blinded fashion and scored in random order and consensually by two readers. The number of total and new enhancing lesions and active images was counted.

RESULTS Eighty-six percent more enhancing lesions and 54% more new enhancing lesions were detected with triple-dose as compared with single-dose non-MT sequences, whereas single-dose MT images depicted 33% more enhancing lesions and 18% more new enhancing lesions than the single-dose non-MT images. Twenty-nine percent more lesions were detected on triple-dose non-MT images than on single-dose MT images. The combination of a triple dose of contrast material and MT did not produce any significant change in detection of enhancing lesions as compared with a triple dose of contrast without MT.

CONCLUSION The use of a triple dose of contrast material is the best approach to maximize the sensitivity of enhanced MR imaging." />
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      <h1 class="highwire-cite-title" id="page-title">Sensitivity of enhanced MR in multiple sclerosis: effects of contrast dose and magnetization transfer contrast.</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">S Bastianello</span>, <span class="highwire-citation-author" data-delta="1">C Gasperini</span>, <span class="highwire-citation-author" data-delta="2">A Paolillo</span>, <span class="highwire-citation-author" data-delta="3">E Giugni</span>, <span class="highwire-citation-author" data-delta="4">O Ciccarelli</span>, <span class="highwire-citation-author" data-delta="5">M P Sormani</span>, <span class="highwire-citation-author" data-delta="6">M A Horsfield</span>, <span class="highwire-citation-author" data-delta="7">M Rovaris</span>, <span class="highwire-citation-author" data-delta="8">C Pozzilli</span> and <span class="highwire-citation-author" data-delta="9">M Filippi</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">November 1998,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">19 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(10) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1863-1867; </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-6436--61618531126" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">S Bastianello </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=S%2BBastianello%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Bastianello%20S&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AS%2BBastianello%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">C Gasperini 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      <div class="highwire-cite-title">Sensitivity of enhanced MR in multiple sclerosis: effects of contrast dose and magnetization transfer contrast.</div>  
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    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Nov 1998, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">19 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(10) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1863-1867; </span></div>
  
  
  
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">S</span> <span class="nlm-surname">Bastianello</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">C</span> <span class="nlm-surname">Gasperini</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">A</span> <span class="nlm-surname">Paolillo</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">E</span> <span class="nlm-surname">Giugni</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">O</span> <span class="nlm-surname">Ciccarelli</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">M P</span> <span class="nlm-surname">Sormani</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">M A</span> <span class="nlm-surname">Horsfield</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">M</span> <span class="nlm-surname">Rovaris</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">C</span> <span class="nlm-surname">Pozzilli</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">M</span> <span class="nlm-surname">Filippi</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Nov 1998, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">19 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(10) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1863-1867; </span></div>
  
  
  
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