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<meta name="DC.Title" content="Thallium-201 Single-Photon Emission CT versus CT for the Detection of Recurrent Squamous Cell Carcinoma of the Head and Neck" />
<meta name="DC.Date" content="1999-07-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="Copyright © American Society of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE : Thallium-201 single-photon emission computed tomography (SPECT) can be used to detect primary squamous cell carcinoma (SCCA) of the head and neck. Nevertheless, there have very few studies performed to evaluate the ability of thallium-201 to depict recurrent SCCA. The purpose of this study was to compare the ability of thallium-201 SPECT with CT to enable detection of recurrent SCCA of the upper aerodigestive tract.

METHODS : Thirty-three patients with a history of previously treated SCCA of the extracranial head and neck underwent thallium-201 SPECT imaging and contrast-enhanced CT. A neuroradiologist and nuclear medicine physician with knowledge of the primary site evaluated all thallium-201 studies for abnormal radiotracer uptake at the primary site. These results were correlated with histologic findings and clinical follow-up in all patients. All patients were followed up for a minimum of 2 years after completion of treatment. The McNemar test was used to determine statistical significance.

RESULTS : The diagnostic accuracy of thallium-201 SPECT was as follows: sensitivity, 88%; specificity, 94%; positive predictive value, 93%; and negative predictive value, 89%. The diagnostic accuracy of CT was as follows: sensitivity, 100%; specificity, 24%; positive predictive value, 55%; and negative predictive value, 100%. The diagnostic accuracy of thallium was superior to CT ( P = .01).

CONCLUSION : Thallium-201 SPECT is superior to CT for differentiating recurrent tumor from post-treatment changes and may complement CT in the evaluation of previously treated SCCA of the extracranial head and neck." />
<meta name="DC.Contributor" content="Suresh K. Mukherji" />
<meta name="DC.Contributor" content="Markus Gapany" />
<meta name="DC.Contributor" content="Doug Phillips" />
<meta name="DC.Contributor" content="Brian Neelon" />
<meta name="DC.Contributor" content="Sean O' O'Brien" />
<meta name="DC.Contributor" content="William McCartney" />
<meta name="DC.Contributor" content="Steve Buejenovich" />
<meta name="DC.Contributor" content="Jayashree S. Parekh" />
<meta name="DC.Contributor" content="Jacob P.  Noordzij" />
<meta name="DC.Contributor" content="Mauricio Castillo" />
<meta name="article:published_time" content="1999-07-01" />
<meta name="article:section" content="HEAD AND NECK" />
<meta name="citation_title" content="Thallium-201 Single-Photon Emission CT versus CT for the Detection of Recurrent Squamous Cell Carcinoma of the Head and Neck" />
<meta name="citation_abstract" lang="en" content="&lt;p&gt;&lt;i&gt;BACKGROUND AND PURPOSE&lt;/i&gt;: Thallium-201 single-photon emission computed tomography (SPECT) can be used to detect primary squamous cell carcinoma (SCCA) of the head and neck. Nevertheless, there have very few studies performed to evaluate the ability of thallium-201 to depict recurrent SCCA. The purpose of this study was to compare the ability of thallium-201 SPECT with CT to enable detection of recurrent SCCA of the upper aerodigestive tract.&lt;/p&gt;&lt;p&gt;&lt;i&gt;METHODS&lt;/i&gt;: Thirty-three patients with a history of previously treated SCCA of the extracranial head and neck underwent thallium-201 SPECT imaging and contrast-enhanced CT. A neuroradiologist and nuclear medicine physician with knowledge of the primary site evaluated all thallium-201 studies for abnormal radiotracer uptake at the primary site. These results were correlated with histologic findings and clinical follow-up in all patients. All patients were followed up for a minimum of 2 years after completion of treatment. The McNemar test was used to determine statistical significance.&lt;/p&gt;&lt;p&gt;&lt;i&gt;RESULTS&lt;/i&gt;: The diagnostic accuracy of thallium-201 SPECT was as follows: sensitivity, 88%; specificity, 94%; positive predictive value, 93%; and negative predictive value, 89%. The diagnostic accuracy of CT was as follows: sensitivity, 100%; specificity, 24%; positive predictive value, 55%; and negative predictive value, 100%. The diagnostic accuracy of thallium was superior to CT (&lt;i&gt;P&lt;/i&gt; = .01).&lt;/p&gt;&lt;p&gt;&lt;i&gt;CONCLUSION&lt;/i&gt;: Thallium-201 SPECT is superior to CT for differentiating recurrent tumor from post-treatment changes and may complement CT in the evaluation of previously treated SCCA of the extracranial head and neck.&lt;/p&gt;" />
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<meta name="citation_publication_date" content="1999/07/01" />
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<meta name="twitter:title" content="Thallium-201 Single-Photon Emission CT versus CT for the Detection of Recurrent Squamous Cell Carcinoma of the Head and Neck" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE : Thallium-201 single-photon emission computed tomography (SPECT) can be used to detect primary squamous cell carcinoma (SCCA) of the head and neck. Nevertheless, there have very few studies performed to evaluate the ability of thallium-201 to depict recurrent SCCA. The purpose of this study was to compare the ability of thallium-201 SPECT with CT to enable detection of recurrent SCCA of the upper aerodigestive tract.

METHODS : Thirty-three patients with a history of previously treated SCCA of the extracranial head and neck underwent thallium-201 SPECT imaging and contrast-enhanced CT. A neuroradiologist and nuclear medicine physician with knowledge of the primary site evaluated all thallium-201 studies for abnormal radiotracer uptake at the primary site. These results were correlated with histologic findings and clinical follow-up in all patients. All patients were followed up for a minimum of 2 years after completion of treatment. The McNemar test was used to determine statistical significance.

RESULTS : The diagnostic accuracy of thallium-201 SPECT was as follows: sensitivity, 88%; specificity, 94%; positive predictive value, 93%; and negative predictive value, 89%. The diagnostic accuracy of CT was as follows: sensitivity, 100%; specificity, 24%; positive predictive value, 55%; and negative predictive value, 100%. The diagnostic accuracy of thallium was superior to CT ( P = .01).

CONCLUSION : Thallium-201 SPECT is superior to CT for differentiating recurrent tumor from post-treatment changes and may complement CT in the evaluation of previously treated SCCA of the extracranial head and neck." />
<meta name="og-title" property="og:title" content="Thallium-201 Single-Photon Emission CT versus CT for the Detection of Recurrent Squamous Cell Carcinoma of the Head and Neck" />
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<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE : Thallium-201 single-photon emission computed tomography (SPECT) can be used to detect primary squamous cell carcinoma (SCCA) of the head and neck. Nevertheless, there have very few studies performed to evaluate the ability of thallium-201 to depict recurrent SCCA. The purpose of this study was to compare the ability of thallium-201 SPECT with CT to enable detection of recurrent SCCA of the upper aerodigestive tract.

METHODS : Thirty-three patients with a history of previously treated SCCA of the extracranial head and neck underwent thallium-201 SPECT imaging and contrast-enhanced CT. A neuroradiologist and nuclear medicine physician with knowledge of the primary site evaluated all thallium-201 studies for abnormal radiotracer uptake at the primary site. These results were correlated with histologic findings and clinical follow-up in all patients. All patients were followed up for a minimum of 2 years after completion of treatment. The McNemar test was used to determine statistical significance.

RESULTS : The diagnostic accuracy of thallium-201 SPECT was as follows: sensitivity, 88%; specificity, 94%; positive predictive value, 93%; and negative predictive value, 89%. The diagnostic accuracy of CT was as follows: sensitivity, 100%; specificity, 24%; positive predictive value, 55%; and negative predictive value, 100%. The diagnostic accuracy of thallium was superior to CT ( P = .01).

CONCLUSION : Thallium-201 SPECT is superior to CT for differentiating recurrent tumor from post-treatment changes and may complement CT in the evaluation of previously treated SCCA of the extracranial head and neck." />
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      <h1 class="highwire-cite-title" id="page-title">Thallium-201 Single-Photon Emission CT versus CT for the Detection of Recurrent Squamous Cell Carcinoma of the Head and Neck</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Suresh K. Mukherji</span>, <span class="highwire-citation-author" data-delta="1">Markus Gapany</span>, <span class="highwire-citation-author" data-delta="2">Doug Phillips</span>, <span class="highwire-citation-author" data-delta="3">Brian Neelon</span>, <span class="highwire-citation-author" data-delta="4">Sean O' O'Brien</span>, <span class="highwire-citation-author" data-delta="5">William McCartney</span>, <span class="highwire-citation-author" data-delta="6">Steve Buejenovich</span>, <span class="highwire-citation-author" data-delta="7">Jayashree S. Parekh</span>, <span class="highwire-citation-author" data-delta="8">Jacob P.  Noordzij</span> and <span class="highwire-citation-author" data-delta="9">Mauricio Castillo</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">July 1999,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">20 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(7) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1215-1220; </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-2168--8123329720" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">Suresh K. 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    <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" class="content-block-markup" xmlns:xhtml="http://www.w3.org/1999/xhtml"><div xmlns:xhtml="http://www.w3.org/1999/xhtml" class="contributors"><ol class="contributor-list" id="contrib-group-1"><li class="contributor" id="contrib-1"><span class="name">Suresh K. Mukherji</span><a id="xref-fn-1-1" class="xref-fn" href="#fn-1"></a><a id="xref-aff-1-1" class="xref-aff" href="#aff-1">a</a>, </li><li class="contributor" id="contrib-2"><span class="name">Markus Gapany</span><a id="xref-aff-1-2" class="xref-aff" href="#aff-1">a</a>, </li><li class="contributor" id="contrib-3"><span class="name">Doug Phillips</span><a id="xref-aff-1-3" class="xref-aff" href="#aff-1">a</a>, </li><li class="contributor" id="contrib-4"><span class="name">Brian Neelon</span><a id="xref-aff-1-4" class="xref-aff" href="#aff-1">a</a>, </li><li class="contributor" id="contrib-5"><span class="name">Sean O' O'Brien</span><a id="xref-aff-1-5" class="xref-aff" href="#aff-1">a</a>, </li><li class="contributor" id="contrib-6"><span class="name">William McCartney</span><a id="xref-aff-1-6" class="xref-aff" href="#aff-1">a</a>, </li><li class="contributor" id="contrib-7"><span class="name">Steve Buejenovich</span><a id="xref-aff-1-7" class="xref-aff" href="#aff-1">a</a>, </li><li class="contributor" id="contrib-8"><span class="name">Jayashree S. Parekh</span><a id="xref-aff-1-8" class="xref-aff" href="#aff-1">a</a>, </li><li class="contributor" id="contrib-9"><span class="name">Jacob P.  Noordzij</span><a id="xref-aff-1-9" class="xref-aff" href="#aff-1">a</a> and </li><li class="last" id="contrib-10"><span class="name">Mauricio Castillo</span><a id="xref-aff-1-10" class="xref-aff" href="#aff-1">a</a></li></ol><ol class="affiliation-list"><li class="aff"><a id="aff-1" name="aff-1"></a><address><sup>a</sup>From the Departments of Radiology (S.K.M., W.M., S.B., M.C.) and Surgery (S.K.M.), University of North Carolina School of Medicine, and the Lineberger Cancer Center (S.K.M., B.N., S.O.), Chapel Hill, NC; the Department of Otolaryngology Head Neck Surgery (M.G.), University of Minnesota School of Medicine, Minneapolis, MN; and the Department of Radiology (D.P., J.S.P.) and Otolaryngology (D.P.), University of Virginia School of Medicine, Charlottesville, VA.</address></li></ol></div></div><a href="http://ajnr-stage2.stage.highwire.org/content/20/7/1215.full" class="hw-link hw-link-article-full-text" data-icon-position="" data-hide-link-title="0">View Full Text</a></div>  </div>

  
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Suresh K.</span> <span class="nlm-surname">Mukherji</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Markus</span> <span class="nlm-surname">Gapany</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">Doug</span> <span class="nlm-surname">Phillips</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Brian</span> <span class="nlm-surname">Neelon</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Sean O'</span> <span class="nlm-surname">O'Brien</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">William</span> <span class="nlm-surname">McCartney</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">Steve</span> <span class="nlm-surname">Buejenovich</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">Jayashree S.</span> <span class="nlm-surname">Parekh</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">Jacob P.</span> <span class="nlm-surname"> Noordzij</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">Mauricio</span> <span class="nlm-surname">Castillo</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Jul 1999, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">20 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(7) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1215-1220; </span></div>
  
  
  
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Suresh K.</span> <span class="nlm-surname">Mukherji</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Markus</span> <span class="nlm-surname">Gapany</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">Doug</span> <span class="nlm-surname">Phillips</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Brian</span> <span class="nlm-surname">Neelon</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Sean O'</span> <span class="nlm-surname">O'Brien</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">William</span> <span class="nlm-surname">McCartney</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">Steve</span> <span class="nlm-surname">Buejenovich</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">Jayashree S.</span> <span class="nlm-surname">Parekh</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">Jacob P.</span> <span class="nlm-surname"> Noordzij</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">Mauricio</span> <span class="nlm-surname">Castillo</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Jul 1999, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">20 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(7) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1215-1220; </span></div>
  
  
  
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